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KÜÇÜKAKKAŞ, OKAN

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    Cross-cultural adaptation and validation of the Turkish version of the Functional Index for Hand Osteoarthritis (FIHOA).
    (2021-04-27T00:00:00Z) Kilicoglu, Mehmet Serkan; Rezvani, Aylin; Yurdakul, Ozan Volkan; Kucukakkas, Okan; Aydin, Teoman; Maheu, Emmanuel; YURDAKUL, OZAN VOLKAN; KÜÇÜKAKKAŞ, OKAN
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    Romatoid artritli hastalarda üst ekstremitede hangi kasların güçleri hastalık aktivitesi, fonksiyonellik ve engellilik ile ilişkilidir?
    (2019-08-01T00:00:00Z) YURDAKUL, OZAN VOLKAN; KÜÇÜKAKKAŞ, OKAN; YURDAKUL, OZAN VOLKAN; KÜÇÜKAKKAŞ, OKAN
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    Cross-cultural adaptation and validation of the back Beliefs Questionnaire to the Turkish language.
    (2019-10-14T00:00:00Z) Arifoğlu, Karaman; Küçükakkaş, Okan; KÜÇÜKAKKAŞ, OKAN
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    PublicationOpen Access
    The reliability and validity of the Turkish version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 (QUALEFFO-31)
    (2021-12-01T00:00:00Z) Ince, Bugra; KÜÇÜKAKKAŞ, Okan; KÜÇÜKAKKAŞ, OKAN
    This study reveals the Turkish version of QUALEFFO-31 has a sufficient level of reliability, validity, and psychometric properties. The questionnaire, which is potentially capable of differentiating patients with fractures, does not appear to have the differential capacity in terms of osteoporosis. Purpose This study aims to conduct the reliability and validity study of QUALEFFO-31 in Turkish and to evaluate the capacity of the questionnaire to distinguish patients in terms of osteoporosis. Methods The original English version was translated into Turkish by two translators whose native language was Turkish. Subsequently, this Turkish version was translated back into English by two different bilingual translators whose native language was English. After this preliminary questionnaire was tested in 30 patients, words, terminology, information errors, and parts difficult to understand were revised, and the questionnaire was finalized. Internal consistency and test-retest analyses were used for the reliability study. For the validity study, convergent-discriminant validity, concurrent validity, factor analysis, known-group validity, and receiver operating characteristic (ROC) analyses were performed. Results A total of 111 patients were evaluated. Internal consistency levels were optimal except for the mental function. ICC coefficients showed good retest reliability for all domains and total tests. The convergent and discriminant validity ratios for the mental function domain were 78% for both and 100% for the other domains. There was a moderate and good negative correlation between QUALEFFO-31 and SF-36 domains which had similar names. Exploratory factor analysis revealed 3 structures. However, there was a spread to the other factors in physical function domain items. Confirmatory factor analysis (CFA) markers were not at a very good fitting level except for the relative chi-square index. When CFA was performed according to the assumed model, the fitting level increased in all analyses. There was no significant differential capacity in terms of osteoporosis or fracture for either QUALEFFO-31 or SF-36. Conclusion The Turkish version of QUALEFFO-31 has a sufficient level of reliability, validity, and psychometric properties. Nevertheless, improvements in pain and mental function domains and some changes applying to the model may increase the psychometric capacity of the questionnaire. The questionnaire, which is potentially capable of differentiating patients with fractures, does not appear to have the differential capacity in terms of osteoporosis.
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    PublicationOpen Access
    Axial Spondyloarthritis and Autosomal Dominant Polycystic Kidney Disease in Two Siblings: A Rare Cooccurrence.
    (2018-03-04) YURDAKUL, OZAN VOLKAN; TAMER, AF; Küçükakkaş, OKAN; REZVANI, AYLİN; YURDAKUL, OZAN VOLKAN; KÜÇÜKAKKAŞ, OKAN; REZVANİ, AYLİN
    Autosomal dominant polycystic kidney disease (ADPKD) is the most frequently occurring hereditary kidney disease, and axial spondyloarthritis (SpA) is one of the most frequently occurring rheumatic diseases. Treatment-related decisions for axial SpA may pose a challenge in case of renal involvement. -e authors describe two siblings with cooccurrence of these two diseases. -e association of these two diseases is not well known. Practitioners should monitor renal function in SpA patients and take treatment-related decisions regarding renal involvement. Antitumor necrosis factor-alpha (anti-TNF-α) agents may be used in case nonsteroidal anti-in
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    Fear Assessment in Inflammatory Rheumatic diseases (FAIR) questionnaire: a cross-cultural adaptation and validation to the Turkish language
    (2018-12-01) Kucukakkas, OKAN; Rezvani, Aylin; Yurdakul, OZAN VOLKAN; Tolu, Sena; Kilicoglu, MEHMET SERKAN; Aydin, TEOMAN; KÜÇÜKAKKAŞ, OKAN; YURDAKUL, OZAN VOLKAN; KILIÇOĞLU, MEHMET SERKAN; AYDIN, TEOMAN
    In chronic inflammatory rheumatic diseases (CIRD), it is important to understand patients- fears towards their disease in order to improve patient-physician dialog, to raise the quality of care offered, and to optimize treatment adherence. In this study, we aimed to translate the Fear Assessment in Inflammatory Rheumatic diseases (FAIR) questionnaire into Turkish and evaluate its psychometric properties in patients with CIRD. One hundred fifteen patients filled the provided socio-demographic information form, FAIR-Tr questionnaire, Hospital Anxiety and Depression Scale (HADS), and Beck-s Hopelessness Scale (BHS). For the analysis of short-term reliability, 50 patients re-filled the FAIR-Tr questionnaire 1week later. Internal consistency was evaluated with Cronbach-s coefficient and test-retest reliability was evaluated with intraclass correlation coefficients (ICC). Construct validity analysis was investigated based on the correlation with HADS and BHS. All patients found FAIR-Tr easily understandable and acceptable. FAIR-Tr internal consistency (Cronbach-s =0.93) and test-retest reliability (ICC=0.91) were excellent. Psychometric validation was proved upon observing high correlation with HADS (Anxiety, r=0.77; Depression, r=0.70) and moderate correlation with BHS (r=0.65). FAIR-Tr is a questionnaire that has excellent internal consistency and test-retest reliability. The successful correlation with HADS and BHS supported its psychometric validity in terms of evaluating the fear in CIRD cases. We think that FAIR-Tr is a specific scale that can help to evaluate the disease- and treatment-related fears of the Turkish patients with CIRD and may be useful in both routine practice and clinical studies.
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    Coexistence of fibromyalgia and metabolic syndrome in females: The effects on fatigue, clinical features, pain sensitivity, urinary cortisol and norepinephrine levels: A cross-sectional study
    (2021-03-01T00:00:00Z) KESKİN, Yaşar; Nas, Kemal; Kilic, Erkan; Sargin, Betul; Kasman, Sevtap Acer; Alkan, Hakan; Sahin, Nilay; CENGİZ, GİZEM; Cuzdan, Nihan; Gezer, Ilknur Albayrak; Keskin, Dilekk; Mulkoglu, Cevriye; Resorlu, Hatice; Ataman, Sebnem; Bal, Ajda; Duruoz, Mehmet Tuncay; Kucukakkas, Okan; YURDAKUL, Ozan Volkan; Melikoglu, Meltem Alkan; Aydin, Yildiray; Ayhan, F. Figen; Bodur, Hatice; Calis, Mustafa; Capkin, Erhan; Devrimsel, Gul; Gok, Kevser; Hizmetli, Sami; Kamanli, Ayhan; Ecesoy, Hilal; Kutluk, Oznur; Sen, Nesrin; Sendur, Omer Faruk; Tekeoglu, Ibrahim; Tolu, Sena; Toprak, Murat; Tuncer, Tiraje; KESKİN, YAŞAR; KÜÇÜKAKKAŞ, OKAN; YURDAKUL, OZAN VOLKAN
    Objectives: This study aims to evaluate the coexistence of metabolic syndrome (MetS) and fibromyalgia syndrome (FMS) and determine the effects of this coexistence on neuroendocrine levels and clinical features of FMS.
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    Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi‑center study.
    (2021-08-28T00:00:00Z) Gok, Kevser; Nas, Kemal; Tekeoglu, Ibrahim; Sunar, Ismihan; Kilic, Erkan; Sargin, Betul; Acer Kasman, Sevtap; Alkan, Hakan; Sahin, Nilay; Cengiz, Gizem; Cuzdan, Nihan; Albayrak Gezer, İlknur; Keskin, Dilek; Mulkoglu, Cevriye; Resorlu, Hatice; Bal, Ajda; Duruoz, Mehmet Tuncay; Yurdakul, Ozan Volkan; Alkan Melikoglu, Meltem; Aydin, Yildiray; Ayhan, Fikriye Figen; Bodur, Hatice; Calis, Mustafa; Capkin, Erhan; Devrimsel, Gul; Ecesoy, Hilal; Hizmetli, Sami; Kamanli, Ayhan; Kutluk, Oznur; Kucukakkas, Okan; Sendur, Omer Faruk; Tolu, Sena; Toprak, Murat; Tuncer, Tiraje; KESKİN, YAŞAR; KÜÇÜKAKKAŞ, OKAN; YURDAKUL, OZAN VOLKAN
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    PublicationOpen Access
    Cross-cultural adaptation and validation of the Behavioral Avoidance Test-Back Pain (BAT-Back) to the Turkish language
    (2020-03-01T00:00:00Z) KÜÇÜKAKKAŞ, Okan; Karaman, Cigdem Arifoglu; KÜÇÜKAKKAŞ, OKAN
    Objective: Pain-avoidance is considered to be one of the major leading factors to develop a chronic low back pain (CLBP). In this study, we aimed to translate the Behavioral Avoidance Test-Back Pain (BAT-Back) into Turkish and evaluate its psychometric properties in patients with CLBP. Methods: 115 patients with CLBP filled the provided socio-demographic information form, the "Oswestry Disability Index (ODI)", the "Fear-Avoidance Beliefs Questionnaire (FABQ)", the "Tampa Scale for Kinesiophobia (TSK)", and the "Hospital Anxiety Depression Scale (HADS)". All patients and 40 pain free controls (PFC) were administered the Turkish version (TrBAT-Back) of the "Behavioral Avoidance Test-Back Pain" test. The internal consistency was evaluated with Cronbach's α coefficient. The test-retest reliability was assessed with the intraclass correlation coefficient (ICC). To evaluate the structural validity of TrBAT-Back, its correlation with FABQ, TSK, ODI, and HADS was examined. Results: The internal consistency of TrBAT-Back was excellent (Cronbach's α = 0.97) and its test-retest reliability was good (ICC = 0.87). Its high correlation with the FABQ-physical activity scores and moderate correlation with the TSK scores supported the structural validity. The TrBAT-Back scores showed a statistically significant moderate correlation with the higher level of pain and disability. Despite the low degree of positive correlation, a high level of anxiety (HADS-anxiety) is potentially associated with avoidance behaviour. CLBP patients and controls differed significantly on TrBAT-Back avoidance scores. Conclusion: We are of the opinion that, compared to the self-report scales, TrBAT-Back will provide more objective data in detecting avoidance behaviour associated with pain in Turkish speaking patients with CLBP.
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    PublicationOpen Access
    Fibromiyalji Sendromu ile Bağırsak Mikrobiyotası Arasındaki İlişkinin Araştırılması
    (2021-03-01T00:00:00Z) Albayrak, Büşra; Süsgün, Seda; Küçükakkaş, Okan; Akbaş, Fahri; Yabacı, Ayşegül; Özçelik, Semra; SÜSGÜN, SEDA; KÜÇÜKAKKAŞ, OKAN; AKBAŞ, FAHRİ; YABACI TAK, AYŞEGÜL; ÖZÇELİK, SEMRA
    Fibromiyalji sendromu (FMS), yetişkin popülasyonda bildirilen prevalansı %3-10 olan, kronik yaygın ağrının sık görülen formlarından biridir. Tipik ağrının klinik görünümü ve ilişkili somatik ve psikolojik semptomların varlığı tanıya temel oluşturur. FMS sinir sistemi disfonksiyonu ile ilişkilidir ve nörotransmitterler fibromiyalji için onaylanmış bir dizi ilacın hedefi olarak rol oynamaktadır. Bununla birlikte, FMS’de altta yatan mekanizmalar kesin olarak henüz bilinmemekle birlikte birçok hipotez ortaya konmuştur. Fibromiyalji ve irritabl bağırsak sendromu (IBS) arasındaki ilişki göz önüne alındığında, değişen bağırsak mikrobiyomu fibromiyalji ile ilişkili olabilir. Bu çalışmada, FMS tanılı hastalarda sağlıklı kontrollere göre değişen bağırsak mikrobiyom düzeylerinin araştırılması amaçlanmıştır. Mikrobiyom çalışması için FMS tanılı 54 hastadan ve 36 sağlıklı kişiden oluşan kohorttan fekal örnekler toplanmıştır. Kontrol grubunda herhangi bir mental ve/veya fiziksel hastalığı olanlar çalışma dışında bırakılmıştır. FMS’li hasta grubu, -American College of Rheumatology (ACR)- 2010 tanı kriterlerine bağlı kalınarak belirlenmiştir. Fekal örnekler, kullanılana kadar -80°C’de muhafaza edilmiş ve buz üzerinde çözülmüş; her ekstraksiyon için 0.3 g feçes tartılmıştır. DNA izolasyonu, ticari kit ile üreticinin protokolüne uygun olarak gerçekleştirilmiştir. Örnekler, gerçek zamanlı polimeraz zincir yöntemi ile Bacteroidetes, Firmicutes, Enterobacter, Lactobacillus, Streptococcus ve Bifidobacterium’a özgül primerler ile 16S rRNA gen amplifikasyonu yapılarak karşılaştırılmıştır. Sonuçlara göre, hasta grubunda Bacteroidetes ve Bifidobacterium istatistiksel olarak anlamlı bir şekilde artarken (p< 0.05), Firmicutes’in azaldığı saptanmıştır (p< 0.001). Enterobacter, Streptococcus ve Lactobacillus için istatistiksel olarak anlamlı sonuç bulunamamıştır (p> 0.05). Bakteriler arasındaki ilişki değerlendirildiğinde, Bacteroidetes ile Firmicutes yüzdesi arasında istatistiksel olarak yüksek anlamlı ve negatif korelasyon bulunurken (r= -0.778, p< 0.001), Enterobacter ve Bifidobacterium yüzdesi arasında orta derecede istatistiksel anlamlılık ve pozitif korelasyon gözlenmiştir (r= 0.460, p= 0.005). Sonuçlar, bağırsak mikrobiyotasının fibromiyaljide rol oynayabileceğini göstermektedir. Bağırsaktaki Firmicutes ve Bacteroidetes filumlarının dengesinin bağırsak homeostazı için önemli etkilere sahip olduğu bilinmektedir. Özetle, daha büyük kohortlarda yapılacak büyük ölçekli araştırmaların, bağırsak mikrobiyomu ve FMS arasındaki ilişkiyi anlamada ve olası tedavi seçeneklerini değerlendirmede etkili olacağı açıktır.