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ÇORAKÇI, ZEYNEP

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    PublicationOpen Access
    Alexithymia is associated with cognitive impairment in patients with Parkinson’s disease
    (2020-05-01T00:00:00Z) Çorakçı, Zeynep; ÇORAKÇI, ZEYNEP
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    Investigation of Cognitive and Sensory Processes in Individuals with Parkinson Disease
    (2021-08-01T00:00:00Z) ÇORAKCI, ZEYNEP; HANOĞLU, LÜTFÜ; ÇORAKÇI, ZEYNEP
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    Cognitive and brain micro-structural correlates of alexithymia in essential tremor patients.
    (2020-07-11T00:00:00Z) Tantik, Pak; Otcu, H; Sengul, HS; Sengul, Y; Alkan, ALPAY; ÇORAKÇI, ZEYNEP; ALKAN, ALPAY
    Essential tremor (ET) is the most common movement disorder which has both motor and non-motor findings such as neuropsychiatic symptoms. Alexithymia is defined as inability to identify and describe emotions experienced by one-s self or others. In our study, we aimed to evaluate the neurocognitive and brain micro-structural correlates of alexithymia in ET. 40 ET patients (mean age = 53.05 +/- 19.74 years), were included. Fahn-Tolosa-Marin Tremor Rating Scale, Toronto Alexithymia Scale (TAS), Beck Depression Inventory, Beck Anxiety Inventory and detailed neurocognitive evaluation were applied to all patients. The patients were divided into three groups based on their TAS scores: no alexithymia, probable alexithymia, definite alexithymia. Diffusion Tensor Imaging (DTI) was performed in all patients. The mean TAS score was 50.05 +/- 10.06. Depressive symptoms and anxiety levels were higher in definite alexithymia (p < 0.001,p < 0.01). Partial correlation controlling for age, gender and educational level between alexithymia scores and each cognitive test showed significant association between similarities (p < 0.001) and phonemic verbal fluency (p = 0.04). Left orbitofrontal cortex average diffusion coefficient (ADC) value (p = 0.05), left anterior cingulate cortex fractional anisotropy (FA) value (p = 0.04), right cuneus FA value (p = 0.04), left amygdala ADC value (p = 0.01) and left insula ADC value (p = 0.02) were differed between groups. TAS and DTImetrics were not found to be independently associated with the level of anxiety (p < 0.001) and depressive symptoms (p < 0.01). As a conclusion, impairments in executive function and complex attention were correlated with higher levels of alexithymia in ET. Many micro-structural alterations were determined to be correlated with alexithymia levels.
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    Brain Microstructural Changes and Cognitive Function in Non-Demented Essential Tremor Patients: A Diffusion Tensor Imaging Study.
    (2020-07-30T00:00:00Z) Sengul, Y; Otcu, H; Sengul, HS; Dowd, H; Ustun, I; Alkan, ALPAY; Louis, ED; ÇORAKÇI, ZEYNEP; ALKAN, ALPAY
    Background Essential tremor (ET) is disease with both motor and non-motor features. Notable among the non-motor features is cognitive impairment. While this impairment has been attributed to cortico-thalamo-cerebellar pathway pathology, it is likely that a more complicated involvement of brain structures underlies cognitive function in ET. Objective To evaluate the brain microstructural changes of both white matter and grey matter in ET using region of interest based diffusion tensor imaging (DTI), and to correlate these changes with cognitive function assessed during detailed neuropsychological testing. Method Thirty-five non-demented ET patients with a range of cognitive function (Clinical Dementia Rating = 0-0.5, mean age = 57.5 +/- 16.7 years, age range = 23-76 years) underwent a comprehensive neuropsychological evaluation and brain magnetic resonance imaging, including DTI. DTI findings were reported as fractional anisotropy, average diffusion coefficient, these values were evaluated for 32 ROIs. Cognitive domains included attention, visuospatial functions, executive function, verbal memory, visual memory, and language. Domain Z-scores were calculated each cognitive domain and compared for each brain region. Results Microstructural changes in prefrontal cortical areas (dorsolateral, ventrolateral), paralimbic and limbic structures (posterior cingulate cortex, precuneus, hippocampus), basal ganglia (substantia nigra, putamen, caudate nucleus) and white matter bundles (corpus callosum, anterior thalamic radiation, longitudinal fasciculus, frontooccipital fasciculus, etc.) correlated with specific domains of cognitive function in ET patients. Conclusion These data suggest that not only the cerebello thalamocortical pathway, but numerous other brain structures are related to level of cognitive performance and possibly underlie cognitive dysfunction in ET.