Person: ÇELİK, BURAK
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Organizational Unit
Job Title
Last Name
ÇELİK
First Name
BURAK
Name
19 results
Search Results
Now showing 1 - 10 of 19
- PublicationMetadata onlyEvaluation of Wound Healing Potential of New Composite Liposomal Films Containing Coenzyme Q10 and D-Panthenyl Triacetate as Combinational Treatment.(2021-02-13T00:00:00Z) Sağıroğlu, Ali Asram; Çelik, Burak; Güler, Eray Metin; Koçyiğit, ABDÜRRAHİM; Özer, Özgen; ASRAM SAĞIROĞLU, ALİ; ÇELİK, BURAK; KOÇYİĞİT, ABDÜRRAHİM
- PublicationMetadata onlyApolipoprotein E4 Mediated Targeting of Blood Brain Barrier Using Nano-Micellar Metal Chelators for Treatment of Alzheimer’s Disease(2015-08-06) BAHADORİ, FATEMEH; ÇELİK, BURAK; Kazdal, Fatma; KUŞMAN, TUBA; BAHADORİ, FATEMEH; ÇELİK, BURAK; KUŞMAN, TUBA
- PublicationOpen AccessDesign, optimization and characterization of coenzyme Q10-and D-panthenyl triacetate-loaded liposomes(2017-01-01) Celik, BURAK; Sagiroglu, ALİ; Ozdemir, Samet; ÇELİK, BURAK; ASRAM SAĞIROĞLU, ALİCoenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications. Keywords: coenzyme Q10, D-panthenyl triacetate, liposomes, response surface methodology, stability
- PublicationMetadata onlyHedeflendirilmiş Nanoilaçlar(2017-09-01) ÖNYÜKSEL, Hayat; BAHADORİ, FATEMEH; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAK
- PublicationMetadata onlyA Novel Nano Formulation For Synthetic And Plant Based Metal Chelators With Blood-Brain Barrier Targeting Property For Treatment Of Alzheimer’s Disease(2015-06-12) BAHADORİ, FATEMEH; Kazdal, Fatma; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAK
- PublicationMetadata onlyIntraocular pressure in infants and its association with hormonal changes with vaginal birth versus cesarean section.(2016-12-01) Elbay, AHMET; CELIK, U; CELIK, BURAK; OZER, OF; KILIC, GÖKHAN; AKKAN, JC; BAYRAKTAR, BİLGE; KAYMAK, NZ; ELBAY, AHMET; ÇELİK, BURAK; ÖZER, ÖMER FARUK; KILIC, GÖKHAN; BAYRAKTAR, BILGE
- PublicationMetadata onlyIn-vitro investigation of changes in efficacy and toxicity of nano-paclitaxel during co-applications with antioxidant natural compounds(2018-05-08) Kazdal, Fatma; BAHADORİ, FATEMEH; Eskandari, Zahra; KOÇYİĞİT, ABDÜRRAHİM; Şahin, Vildan Betül; Öz Öztenekeci, Burcu; ÇELİK, BURAK; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİM; ÇELİK, BURAK
- PublicationMetadata onlyEvaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients.(2014-08-19T00:00:00Z) YAZGAN, S; CELIK, U; KALDıRıM, H; AYAR, O; Elbay, AHMET; AYKUT, V; CELIK, BURAK; TAŞ, M; ELBAY, AHMET; ÇELİK, BURAK
- PublicationMetadata onlyPlant extracts as metal chelators for treatment of Alzheimer’s disease(2015-08-06) Kazdal, Fatma; ÇELİK, BURAK; BAHADORİ, FATEMEH; Ertaş, Abdulselam; ÇELİK, BURAK; BAHADORİ, FATEMEH
- PublicationMetadata onlyPreliminary Studies on Preparation of Mucoadhesive Tablets Using Different Polymers(2015-11-28) ÇELİK, BURAK; ÜNER, M; ÇELİK, BURAK