Person: ÇELİK, BURAK
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Publication Evaluation of Wound Healing Potential of New Composite Liposomal Films Containing Coenzyme Q10 and D-Panthenyl Triacetate as Combinational Treatment.(2021-02-13T00:00:00Z) Sağıroğlu, Ali Asram; Çelik, Burak; Güler, Eray Metin; Koçyiğit, ABDÜRRAHİM; Özer, Özgen; ASRAM SAĞIROĞLU, ALİ; ÇELİK, BURAK; KOÇYİĞİT, ABDÜRRAHİMPublication Design, optimization and characterization of coenzyme Q10-and D-panthenyl triacetate-loaded liposomes(2017-01-01) Celik, BURAK; Sagiroglu, ALİ; Ozdemir, Samet; ÇELİK, BURAK; ASRAM SAĞIROĞLU, ALİCoenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications. Keywords: coenzyme Q10, D-panthenyl triacetate, liposomes, response surface methodology, stabilityPublication Eplerenone nanoemulsions for treatment of hypertension. Part I: Experimental design for optimization of formulations and physical characterization(2018-06-01T00:00:00Z) Ozdemir, Samet; Celik, BURAK; Acar, Ebru Turkoz; Duman, Gulengul; Uner, Melike; ÇELİK, BURAKNanoemulsions of eplerenone (EP) were designed with the aim of improving its bioavailability for an effective antihypertensive therapy. Nanoemulsions were prepared by high shear homogenization and ultrasonication methods. Oleyl erucate, Brij (R) 35, Tween (R) 80, Tego Care (R) 450 and Poloxamer (R) 407 were used as the liquid lipid and surfactants for optimization of formulations by design of experiments approach. Thus, oil, surfactant and water contents of nanoemulsions were defined by determination of their droplet size and droplet size distribution by dynamic light scattering method. Formulations were screened by scanning electron microscopy. Drug payload and release properties of the formulations were investigated. Analytical quantification method of EP was validated by high performance liquid chromatograpy. Nanoemulsions having average droplet size between 150.6 nm and 205.8 nm were gained with homogenous droplet size distribution and high entrapment efficiency (84.47-98.51%). Formulations released 44.37-82.87% of EP within 1 h and drug release was completed up to 5-6 h. Thus, drug release characteristics of formulations optimized in this study might introduce benefits for rapid response and maintenance of treatment in hypertension attacks. As a result, design of experiments approach provided accurate and consistent datum with those obtained from experiments on the bench for optimization of formulations.Publication A Novel Nano Formulation For Synthetic And Plant Based Metal Chelators With Blood-Brain Barrier Targeting Property For Treatment Of Alzheimer’s Disease(2015-06-12) BAHADORİ, FATEMEH; Kazdal, Fatma; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAKPublication Hedeflendirilmiş Nanoilaçlar(2017-09-01) ÖNYÜKSEL, Hayat; BAHADORİ, FATEMEH; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAKPublication Intraocular pressure in infants and its association with hormonal changes with vaginal birth versus cesarean section.(2016-12-01) Elbay, AHMET; CELIK, U; CELIK, BURAK; OZER, OF; KILIC, GÖKHAN; AKKAN, JC; BAYRAKTAR, BİLGE; KAYMAK, NZ; ELBAY, AHMET; ÇELİK, BURAK; ÖZER, ÖMER FARUK; KILIC, GÖKHAN; BAYRAKTAR, BILGEPublication INFLUENCE OF VEHICLES AND PENETRATION ENHANCERS ON ANTI-INFLAMMATORY EFFECT OF 18-beta GLYCYRRHETINIC ACID: KINETIC MODELLING OF DRUG RELEASE, IN VIVO AND EX VIVO EXPERIMENTS(2020-07-01T00:00:00Z) Karaman, Ecem Fatma; ÇELİK, BURAK; Ozdemir, Samet; Tekkeli, Evrim Kepekci; Demirkoz, Asli Barla; Gonullu, Umit; Uner, Melike; ÇELİK, BURAK; TEKKELİ, ŞERİFE EVRİMTopical formulations of 18-beta glycyrrhetinic acid (18-beta GA) were designed for use in relieving inflammatory and painful conditions of the skin. Formulations were containing penetration enhancers that differ in penetration enhancing mechanisms. Anti-inflammatory effects of formulations and effects of penetration enhancers on penetration and permeation of the drug through rat skin were investigated. The total amount of 18-beta GA permeated from the base oil/water emulsion (53.19 +/- 22.25 mcg/cm(2) ) was approximately twice higher than the base oleaginous cream (29.17 +/- 3.85 mcg/cm(2)) while there was no 18-beta GA permeation from the base hydrogel formulation to the skin (p < 0.05). Incorporation of propylene glycol was generally found to increase 18-beta GA permeation to the skin. The highest oedema inhibiting activity was achieved in the oil/water emulsion containing propylene glycol followed by the base oil/water emulsion without a penetration enhancer (p < 0.05). This result was consistent with the ex vivo study. Limonene and oleic acid were found to be insufficient in 18-beta GA permeation to the skin.Publication In-vitro investigation of changes in efficacy and toxicity of nano-paclitaxel during co-applications with antioxidant natural compounds(2018-05-08) Kazdal, Fatma; BAHADORİ, FATEMEH; Eskandari, Zahra; KOÇYİĞİT, ABDÜRRAHİM; Şahin, Vildan Betül; Öz Öztenekeci, Burcu; ÇELİK, BURAK; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİM; ÇELİK, BURAKPublication Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients.(2014-08-19T00:00:00Z) YAZGAN, S; CELIK, U; KALDıRıM, H; AYAR, O; Elbay, AHMET; AYKUT, V; CELIK, BURAK; TAŞ, M; ELBAY, AHMET; ÇELİK, BURAKPublication Plant extracts as metal chelators for treatment of Alzheimer’s disease(2015-08-06) Kazdal, Fatma; ÇELİK, BURAK; BAHADORİ, FATEMEH; Ertaş, Abdulselam; ÇELİK, BURAK; BAHADORİ, FATEMEH