Person: ALKAN, ALPER
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Publication Displacement of a Dental Implant and Cover Screws into Submandibular Space: A Case Report.(2017-05-23T00:00:00Z) AKKOYUN, EMİNE FULYA; DEMİRBAŞ, AHMET EMİN; TAŞDEMİR, ZEKERİYA; KÜTÜK, NÜKHET; ALKAN, ALPER; AKKOYUN, EMİNE FULYA; KÜTÜK, NÜKHET; ALKAN, ALPERPublication Bone stress and damage distributions during dental implant insertion: a novel dynamic FEM analysis(2021-12-01T00:00:00Z) DEMİRBAŞ, AHMET EMİN; EKİCİ, RECEP; Karakaya, Mustafa; ALKAN, ALPER; ALKAN, ALPERThe objective of this research was to evaluate the stress and damage occurring on the bone model of D2 quality during implant insertion procedure using a novel dynamic finite element analysis (FEA) modeling. Three-dimensional finite element method was used to simulate the implant placement into the mandible. The cross-sectional model of the implant was created in SolidWorks 2007 software. The implant model was created to resemble a commercially available fine thread bone level dental implant (Bilimplant (R), Turkey). 3 D bone models created with and without cortical bone drilling were specified according to D2 bone (Misch-s Bone Classification) with a 1.5 mm cortical bone thickness. The stress patterns in both cancellous and cortical crestal bone were examined during implant insertion by using a novel dynamic FEA in ABACUS/Explicit (ABAQUS/Explicit version 6.14). According to the results of the dynamic FEA, it was reduced stress and damage significantly on the crestal bone region using the cortical drill before the implantation. Also, implant placement time was shorter when the cortical drill was used. The present research is a pilot study using a novel dynamic FEM to model and simulate the dental implant insertion process. This study showed that the use of cortical drills decreased the stress in the bone, especially crestal region, and shortened the whole implant insertion time.Publication Effects of combination TGF-B1 transfection and platelet rich plasma (PRP) on three-dimension chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells(2019-10-13) Salkin, Hasan; GÖNEN, ZEYNEP BURÇİN; ÖZCAN, SERVET; Lekesizcan, Ayca; BAHAR, DİLEK; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPERAim: The aim of this study was to evaluate the effects of standard culture medium and chondrogenic differentiation medium with PRP on chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells (rabbit DPSCs) that are transfected with transforming growth factor-beta 1 (TGF-B1) gene, based on the hypothesis of TGF- B1 and PRP can be effective on the chondrogenesis of stem cells. Materials and Methods: Rabbit DPSCs were characterized by using flow cytometry, immunofluorescent staining, quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and differentiation tests. For the characterization, CD29, CD44 and CD45 mesenchymal cell markers were used. Rabbit DPSCs were transfected with TGF-B1 gene using electroporation technique in group 1; with PRP 10% in group 2; with chondrogenic medium in group 3; with both chondrogenic medium and PRP in group 4. DPSCs were cultured in medium with 10% inactive PRP in group 5, chondrogenic medium in group 6, chondrogenic medium with PRP 10% in group 7. SOX9, MMP13 and Aggrecan gene expression levels were evaluated in 3, 6, 12. and 24. days by qRT-PCR. Results: The expression levels of SOX9, MMP13 and Aggrecan were higher in group 2, 3 and group 7 in 3th day however in 24th day group 7 and group 2 were found higher. The expression levels changed by time-dependent. The extracellular matrix of the cells in experimental groups were positively stained with safranin O and toluidine blue. Conclusion: The combination in culture medium of TGF-B1 gene transfection and 10% PRP accelerates the chondrogenic differentiation of DPSCs.Publication The role of platelet count, mean platelet volume, and the mean platelet volume/platelet count ratio in predicting postoperative vomiting in children after deep sedation(2016-10-01) Canpolat, Dilek G.; DOĞRUEL, FATMA; GÖNEN, ZEYNEP BURÇİN; Yilmaz, Canay; ZARARSIZ, GÖKMEN; Alkan, ALPER; ALKAN, ALPERObjectives: To determine the role of hemogram parameters such as platelet count (PLT), mean platelet volume (MPV), and the MPV/PLT ratio in predicting the risk of postoperative vomiting (POV) in children after tooth extraction under deep sedation.Publication Spontaneous and Excellent Healing of Bilateral Brown Tumors in Mandible after Endocrinal Therapy and Subtotal Parathyroidectomy: Case Report with 4-Year Follow-Up(2018-01-01) YÜCESOY, TÜRKER; KILIÇ, ERDEM; DOĞRUEL, FATMA; BAYRAM, FAHRİ; ALKAN, ALPER; AKCAN, Alper Celal; ÖZTÜRK, FİGEN; YÜCESOY, TÜRKER; KILIÇ, ERDEM; ALKAN, ALPERPrimary hyperparathyroidism is an endocrine disorder occurring due to increased secretion of parathormone resulting in a complex of clinical, anatomical, and biochemical alterations. On the other hand, excision of a parathyroid adenoma can normalize the metabolic status. A 24-year-old man was referred to the hospital with bilateral swelling and spontaneous gingival bleeding from posterior of the mandible also with radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions. After consultations, the patient was hospitalized in the endocrinology department where further tests were performed due to highly increased PTH level as 714 pg/ml. Bilateral brown tumors started to regress spontaneously, and no additional surgery was required after subtotal parathyroidectomy was performed. The presented case is the first patient whose bilateral brown tumors in the jaws spontaneously and totally healed after subtotal parathyroidectomy and endocrinal therapy who was strictly followed up for 4 years even though the lesions were associated with impacted third molars.Publication Intravenous ketamine, propofol and propofol-ketamine combination used for pediatric dental sedation: A randomized clinical study(2016-05-01) Kutuk, Nukhet; Canpolat, Dilek Gunay; Yildirim, Mustafa Denizhan; AKSU, RECEP; Alkan, ALPER; Cantekin, Kenan; KÜTÜK, NÜKHET; ALKAN, ALPERBackground and Objective: Dental treatments cannot be always performed under local anesthesia in pediatric non-cooperative patients. For this purpose, different anesthetic techniques have been applied to increase patient comport to dental treatments.Publication Is It Possible to Shorten the Jaws Using Contraction Osteogenesis?(2011-06-01T00:00:00Z) Alkan, Alper; Kilic, Erdem; Ocak, Hakan; Ozturk, Mustafa; Gunhan, Omer; ALKAN, ALPERPurpose: This study investigated whether shortening of osteotomized jaws is possible.Publication Gastrointestinal tract metastasis of mandibular diffuse large B-cell lymphoma(2018-09-01) YÜCESOY, TÜRKER; KILIÇ, ERDEM; Ocak, Hakan; ALKAN, ALPER; DENİZ, KEMAL; YÜCESOY, TÜRKER; KILIÇ, ERDEM; ALKAN, ALPERNot only diffuse large B-cell lymphoma is a malignancy, but also is initially and orally diagnosed in early stages. However, it could be misdiagnosed with other oral pathologies. However yet, early diagnosis is still crucial for the prognosis, morbidity, and mortality in such cases. Additionally, whole-body scanning with positron emission tomography/computed tomography should be performed for diagnosis and treatment process.Publication Reusing dental implants?: an experimental study for detecting the success rates of re-osseointegration(2018-06-19) Ulu, Murat; KILIÇ, ERDEM; SOYLU, EMRAH; KÜRKÇÜ, MEHMET; ALKAN, ALPER; KILIÇ, ERDEM; ALKAN, ALPERBackground: The aim of this study was to histomorphometrically compare the implant-host integration between retrieved implants and new implants. Methods: Jaws in 10 male beagle dogs were divided into four groups, and 36 dental implants were inserted into the jaws. In groups 1 and 2, experimental peri-implantitis was induced within 2 months after implant insertion. In group 1, surface decontamination of implants was achieved using air-flow and citric acid. In group 2, implants were sterilized with autoclave after air-flow and citric acid surface decontamination. Subsequently, these implants were inserted in contralateral jaws of the same dogs and a 3-month period was allowed for osseointegration. In group 3, the implants were removed from human jaws due to peri-implantitis and were inserted into dog jaws following surface cleaning protocol and sterilization with autoclave and a 3-month period was allowed for osseointegration. Group 4 was set as the control group. After the osseointegration period, all the animals were sacrificed. The degree of osseointegration in all groups was evaluated by evaluating the ISQ values and by using histomorphometric measurements. Results: Histological findings showed that bone-implant contact (BIC) percentage (mean ± SD) was 83.39% ± 6.37 in group 1, 79.93% ± 11.83 in group 2, 75.45% ± 9.09 in group 3, and 80.53 ± 5.22 in group 4. Moreover, the resonance frequency analysis (RFA) and ISQ values were similar in all four groups both before and after the implantation. Conclusions: The results of this experimental study indicated that there is no significant difference between new dental implants and re-used dental implants with regards to osseointegration around the implant.Publication Determination of the effect of osteoporosis on bone mineral density changes in jaw bones(2019-07-31T00:00:00Z) Şeker, Elif Dilara; Yücesoy, Türker; Aydın, Teoman; Erten, Dilek; Alkan, Alper; ŞEKER, ELIF DILARA; YÜCESOY, TÜRKER; ÜNVER, TUĞBA; AYDIN, TEOMAN; ALKAN, ALPER