Person:
ALKAN, ALPER

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ALPER
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ALKAN
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Now showing 1 - 10 of 90
  • PublicationMetadata only
    Albümin-gluteraldehit doku yapıştırıcısının insan dişeti fibroblast hücreleri üzerindeki etkilerinin incelenmesi
    (2020-09-01T00:00:00Z) DOGANAY, ÖZGE; ALKAN, ALPER; DİKER, NURETTİN; ATASOY, SEZEN; DOĞANAY, ÖZGE; ATASOY, SEZEN; DİKER, NURETTİN; ALKAN, ALPER
  • PublicationMetadata only
    Effects of combination TGF-B1 transfection and platelet rich plasma (PRP) on three-dimension chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells
    (2019-10-13) Salkin, Hasan; GÖNEN, ZEYNEP BURÇİN; ÖZCAN, SERVET; Lekesizcan, Ayca; BAHAR, DİLEK; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPER
    Aim: The aim of this study was to evaluate the effects of standard culture medium and chondrogenic differentiation medium with PRP on chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells (rabbit DPSCs) that are transfected with transforming growth factor-beta 1 (TGF-B1) gene, based on the hypothesis of TGF- B1 and PRP can be effective on the chondrogenesis of stem cells. Materials and Methods: Rabbit DPSCs were characterized by using flow cytometry, immunofluorescent staining, quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and differentiation tests. For the characterization, CD29, CD44 and CD45 mesenchymal cell markers were used. Rabbit DPSCs were transfected with TGF-B1 gene using electroporation technique in group 1; with PRP 10% in group 2; with chondrogenic medium in group 3; with both chondrogenic medium and PRP in group 4. DPSCs were cultured in medium with 10% inactive PRP in group 5, chondrogenic medium in group 6, chondrogenic medium with PRP 10% in group 7. SOX9, MMP13 and Aggrecan gene expression levels were evaluated in 3, 6, 12. and 24. days by qRT-PCR. Results: The expression levels of SOX9, MMP13 and Aggrecan were higher in group 2, 3 and group 7 in 3th day however in 24th day group 7 and group 2 were found higher. The expression levels changed by time-dependent. The extracellular matrix of the cells in experimental groups were positively stained with safranin O and toluidine blue. Conclusion: The combination in culture medium of TGF-B1 gene transfection and 10% PRP accelerates the chondrogenic differentiation of DPSCs.
  • PublicationMetadata only
    The role of platelet count, mean platelet volume, and the mean platelet volume/platelet count ratio in predicting postoperative vomiting in children after deep sedation
    (2016-10-01) Canpolat, Dilek G.; DOĞRUEL, FATMA; GÖNEN, ZEYNEP BURÇİN; Yilmaz, Canay; ZARARSIZ, GÖKMEN; Alkan, ALPER; ALKAN, ALPER
    Objectives: To determine the role of hemogram parameters such as platelet count (PLT), mean platelet volume (MPV), and the MPV/PLT ratio in predicting the risk of postoperative vomiting (POV) in children after tooth extraction under deep sedation.
  • PublicationOpen Access
    Spontaneous and Excellent Healing of Bilateral Brown Tumors in Mandible after Endocrinal Therapy and Subtotal Parathyroidectomy: Case Report with 4-Year Follow-Up
    (2018-01-01) YÜCESOY, TÜRKER; KILIÇ, ERDEM; DOĞRUEL, FATMA; BAYRAM, FAHRİ; ALKAN, ALPER; AKCAN, Alper Celal; ÖZTÜRK, FİGEN; YÜCESOY, TÜRKER; KILIÇ, ERDEM; ALKAN, ALPER
    Primary hyperparathyroidism is an endocrine disorder occurring due to increased secretion of parathormone resulting in a complex of clinical, anatomical, and biochemical alterations. On the other hand, excision of a parathyroid adenoma can normalize the metabolic status. A 24-year-old man was referred to the hospital with bilateral swelling and spontaneous gingival bleeding from posterior of the mandible also with radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions. After consultations, the patient was hospitalized in the endocrinology department where further tests were performed due to highly increased PTH level as 714 pg/ml. Bilateral brown tumors started to regress spontaneously, and no additional surgery was required after subtotal parathyroidectomy was performed. The presented case is the first patient whose bilateral brown tumors in the jaws spontaneously and totally healed after subtotal parathyroidectomy and endocrinal therapy who was strictly followed up for 4 years even though the lesions were associated with impacted third molars.
  • PublicationUnknown
    Total antioxidant capacity and total oxidant status of synovial fluids in patients with temporomandibular joint pain and dysfunction
    (2012-12-01T00:00:00Z) Etoz, Osman A.; Akcay, Huseyin; Neselioglu, Salim; Erel, Ozcan; Alkan, Alper; ALKAN, ALPER
    Objectives The objective of this study was to investigate whether a relationship exists between total antioxidant capacity (TAC) and total oxidant status (TOS) of synovial fluids (SFs) of temporomandibular joint (TMJ) pain patients with pain and dysfunction.
  • PublicationUnknown
    Accidental benzalkonium chloride (zephiran) injection
    (2011-12-01T00:00:00Z) Kilic, Erdem; Er, Nilay; Alkan, Alper; Ferahbas, Ayten; ALKAN, ALPER
    We report a case of an accidental injection of benzalkonium chloride (zephiran) instead of a local anesthetic agent during a tooth extraction. The sudden development of chin and neck swelling led to dyspnea and the patient lost consciousness. She was sent to an emergency clinic by her dentist immediately. After medical treatment for 20 days, the necrotic tissue was debrided and a gingival sulcoplasty was performed. Healing was uneventful. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:e103-e105)
  • PublicationMetadata only
    Fibrous Dysplasia of Posterior Maxilla That Impeding The Use Of Prosthesis: A Case Report
    (2019-05-10T00:00:00Z) Pergel, Taha; Demirbaş, Ahmet Emin; Ülker, Ömer; Alkan, Alper; PERGEL, TAHA; ALKAN, ALPER
  • PublicationMetadata only
    Acute fetal distress following tooth extraction and abscess drainage in a pregnant patient with maxillofacial infection
    (2013-03-01T00:00:00Z) Celebi, Nükhet; Kutuk, M. S.; TAŞ, Mert; SOYLU, Emrah; Etoz, O. A.; Alkan, A.; KÜTÜK, NÜKHET; ALKAN, ALPER
    Oral infections have been implicated in adverse pregnancy outcomes such as pre-eclampsia, premature delivery and growth retardation. A 28-year-old and 9 months pregnant otherwise healthy woman with a complaint of facial swelling and dental pain was referred to the Department of Oral and Maxillofacial Surgery. Oral examination revealed perimandibular and masticator space infection related to the left mandibular third molar tooth. Eight hours after surgical intervention, fetal distress developed. The patient was immediately taken into surgery and a male baby delivered by Caesarean section. The baby was then admitted to the intensive care unit. On the twelfth day of his admission, the baby was discharged in good health. Severe maxillofacial infection in pregnancy is a medically complicated situation which should be treated by an oral and maxillofacial surgeon in consultation with an obstetric and gynaecology service.
  • PublicationMetadata only
    Displacement of a Dental Implant and Cover Screws into Submandibular Space: A Case Report.
    (2017-05-23T00:00:00Z) AKKOYUN, EMİNE FULYA; DEMİRBAŞ, AHMET EMİN; TAŞDEMİR, ZEKERİYA; KÜTÜK, NÜKHET; ALKAN, ALPER; AKKOYUN, EMİNE FULYA; KÜTÜK, NÜKHET; ALKAN, ALPER
  • PublicationMetadata only
    Dudak Damak Yarığı Onarılmış Bir Hastada Ortognatik ve Kemik İçi İmplant Cerrahisi ile Dentofasiyal Deformitenin Tedavisi Olgu Sunumu
    (2017-09-24T00:00:00Z) BİLGE, SUHEYB; DEMİRBAŞ, AHMET EMİN; KÜTÜK, NÜKHET; ALKAN, ALPER; GÜL AMUK, NİSA; KILIÇ, KEREM; KÜTÜK, NÜKHET; ALKAN, ALPER