Person: ÖZER, ÖMER FARUK
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ÖMER FARUK
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ÖZER
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Publication Metadata only Decreased Levels of Fasting Serum Leptin in Patients With Schizophrenia: A Case-Control Study(2020-01-01T00:00:00Z) Şahbaz, Çiğdem; Kurtulmuş, Ayşe; Kırkpınar, İsmet; Gülöksüz, Sinan; ÖZER, ÖMER FARUKPublication Metadata only Evaluation of Serum Fetuin-A, Parathyroid Hormone and Levels in Patients with Tympanosclerosis(2019-11-01T00:00:00Z) Baki, Ahmet; Savran, Fatih; Yıldız, Muhammet; Özer, Ömer Faruk; ÖZER, ÖMER FARUKPublication Open Access The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report(2020-07-01T00:00:00Z) Kelahmetoğlu, Osman; Tok, Enis Olgu; Özer, Ömer Faruk; Yeniocak, Ali; Yağmur, Çağlayan; Eşrefoğlu, Mukaddes; Koçyiğit, Abdürrahim; Yıldız, Kemalettin; Güneren, Ethem; KELAHMETOĞLU, OSMAN; ÖZER, ÖMER FARUK; YENİOCAK, ALİ; EŞREFOĞLU, MUKADDES; KOÇYİĞİT, ABDÜRRAHİM; YILDIZ, KEMALETTİN; GÜNEREN, ETHEMObjective: Vitamin D is a vitamin that has gained popularity in recent years and has an anti-inflammatory and immunmodular effect. In the literature review we conducted, there was no study investigating the effect of vitamin D to prevent ischemia reperfusion (I/R) injury in skeletal muscle. The aim of this study was to investigate the effect of vitamin D on skeletal muscle in I/R injury. Methods: Six rats were used in each group including ischemia group (group I) and experimental group (group D given vitamin D). In the histopathological examination, inflammation and apoptosis levels were studied in gastrocnemius muscle. In biochemical analysis, total oxidative stress and total antioxidant and catalase levels were evaluated in anterior tibialis muscle. Results: The number of apoptotic cells in group D were found significantly lower than group I. In the terms of total antioxidants and catalase levels, there were significant difference between group D and group I. Conclusion: Our results support the hypothesis that vitamin D is an agent that can be used to prevent I/R injury.Publication Open Access Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study.(2022-05-01T00:00:00Z) Erdoğan, Fırat; Şenkal, Evrim; Özer, Ömer Faruk; İpek, İlke Özahi; Altuntaş, Şükriye Leyla; Özde, Şükriye; ÖZER, ÖMER FARUKBackground: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. Objective: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). Design and setting: Prospective study at a university hospital in Turkey. Methods: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. Results: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. Conclusion: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.Publication Open Access Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?(2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNObjective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.Publication Metadata only D Vitamini Eksikliği ile Endotel Disfonksiyonu Göstergelerinden Serum Endocan ve Asimetrik Dimetilarjinin Düzeyleri Arasındaki İlişki(2020-05-01T00:00:00Z) Yurdakul, Selin; Çakırca, Mustafa; Özer, Ömer Faruk; Ekici, İskender; Karatoprak, Cumali; ÇAKIRCA, MUSTAFA; ÖZER, ÖMER FARUK; KARATOPRAK, CUMALİ