Person: ÖZER, ÖMER FARUK
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ÖMER FARUK
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ÖZER
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Publication Open Access Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.(2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Open Access The Effect of Serum Bone Sialoprotein Levels on Tympanosclerosis(2020-07-01T00:00:00Z) Baki, Ahmet; Yildiz, Muhammet; ÖZER, Ömer Faruk; ÇAĞLAR, Hifa Gülru; ÖZER, ÖMER FARUK; ÇAĞLAR, HİFA GÜLRUObjective: This study aimed to investigate serum bone sialoprotein (BSP) levels in patients with tympanosclerosis (TS). Methods: We included into this study 24 patients with TS and 24 asymptomatic healthy volunteers. Our study consisted of two groups: TS group (n=24), comprising of patients who underwent surgery for chronic otitis media and had tympanosclerotic plaques; and a control group (n=24), comprising of healthy individuals without ear problems. The serum BSP levels were measured and the results were compared between the two groups. Results: In the TS group, there were 15 female and nine male patients. The ages of the females ranged from 24 to 54 years, while those of the males ranged from 34 to 55 years; the average age was 40.46 +/- 9.75 and 43.11 +/- 6.77, respectively. In the control group, there were 14 females and ten males. The ages of the females ranged from 30 to 48 years, while those of the males ranged from 27 to 47 years; the average age was 40.25 +/- 5.28 and 38.4 +/- 27.08, respectively. There was a statistically significant difference in BSP levels between the two groups (p=0.001). In addition, there was a moderate positive correlation between BSP and hearing levels. Conclusion: The serum BSP levels were higher in the TS group than in the control group and might have some effect on TS. Further studies on a large number of subjects using serum and tissue BSP levels should be designed to affirm the effects of BSP on TS.Publication Open Access Assessment of serum endocan levels in patients with beta-thalassemia minor(2022-02-01T00:00:00Z) Zorlu, Mehmet; Ozer, Ömer Faruk; Karatoprak, Cumali; Kıskaç, Muharrem; Çakırca, Mustafa; ZORLU, MEHMET; ÖZER, ÖMER FARUK; KARATOPRAK, CUMALİObjective: Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organs. Our aim was to investigate the relationship between the beta-thalassemia minor patients and the healthy control group in terms of serum endocan level. Methods: The study was performed in a total of 80 subjects. They were divided into two groups, the beta-thalassemia minor group (n=40) and the healthy control group (n=40). Serum endocan levels, age, sex, body mass index value, and tobacco use data of these groups were compared. Results: No statistically significant difference was detected between the two groups in terms of age, sex, and body mass index values (p>0.05). Endocan levels were measured to be 206.85±88.1 pg/mL in the beta-thalassemia minor group and 236.1±162.8 pg/mL in the control group with no significant difference between the groups in terms of serum endocan levels (p>0.05). Conclusions: In our study, there was no change in endocan level in beta-thalassemia minor. This might be because serum endocan levels are affected by multi-factorial reasons. Serum endocan levels may be altered secondarily to decreased beta-globin chain, increased sympathetic activity due to anemia, or platelet dysfunction induced by oxidative stress in beta-thalassemia minor. Further multicenter studies involving more patients are necessary to demonstrate this.Publication Metadata only Total antioxidant status and oxidative stress in recurrent aphthous stomatitis(2016-03-01) TUGRUL, Selahattin; Kocyigit, ABDÜRRAHİM; Dogan, REMZİ; Eren, SABRİ BAKİ; SENTURK, EROL; Ozturan, ORHAN; OZAR, Omer Faruk; KOÇYİĞİT, ABDÜRRAHİM; DOĞAN, REMZI; EREN, SABRİ BAKİ; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; ÖZER, ÖMER FARUKBackgroundRecurrent aphthous stomatitis is an idiopathic, chronic, recurrent inflammatory disease of the oral mucosa. It is thought that oxidative stress caused by systemic inflammation plays a basic role in the etiopathogenesis of recurrent aphthous stomatitis. The aim of this study is to review oxidative status and DNA damage in recurrent aphthous stomatitis.Publication Metadata only Upper reference limits for serum thyroid stimulating hormone levels in Turkish children(2014-06-01) ARAL, H.; Ozer, O. F.; ONUR, H.; ÇİLİNGİRTÜRK, AHMET METE; AKYILDIZ, M.; Ozgen, I. T.; GUVENEN, GÜVENÇ; KACAN, P. A.; COMERT, S.; SERIN, E.; ÖZER, ÖMER FARUK; ÖZGEN, İLKER TOLGA; GÜVENEN, GÜVENÇPublication Metadata only The Diagnostic Value of SCUBE1 in Acute Appendicitis(2017-01-01) DURSUN, A.; METIN, HÜSEYİN; GULEN, BEDİA; SONMEZ, ERTAN; Ozer, O. F.; SÖNMEZ, ERTAN; GÜLEN, BEDİA; METİN, HÜSEYİN; ÖZER, ÖMER FARUKBackground: SCUBE1 has recently been studied as a diagnostic biomarker for acute coronary syndrome, ischemic stroke, and acute mesenteric ischemia. The aim of this study is to evaluate the value of SCUBE1 and routine parameters used in patients diagnosed with acute appendicitis.Publication Open Access Comparison of the biochemical and radiological criteria for lumbar disc degeneration(2018-09-01) Seyithanoglu, MEHMET HAKAN; Kitis, SERKAN; Ozer, Omer Faruk; Kocyigit, ABDÜRRAHİM; DÜNDAR, Tolga; Papaker, Meliha Gundeg; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMBackground: The relationship between radiological degeneration criteria on lumbar magnetic resonance imaging (MRI) and both the keratan sulfate (KS) and chondroitin sulfate (ChS) levels was examined in disc material taken from patients undergoing lumbar disc herniation (LDH) surgery. To examine whether the biochemical and radiological degeneration criteria testing the reliability of radiological degeneration findings agreed and to evaluate the contribution of the KS/ChS ratio to disc form (protruding or extruding).Publication Metadata only RELATIONSHIP BETWEEN RHEUMATOID ARTHRITIS DISEASE ACTIVITY AND MYELOPEROXIDASE AND CATALASE ACTIVITIES AND THIOL LEVELS(2016-01-01) Camli, AHMET ADİL; TAŞPINAR, ÖZGÜR; Aydin, TEOMAN; KEPEKÇİ, MÜGE; Ozer, O. F.; Keskin, YAŞAR; Selek, S.; Mutluer, A. S.; ÇAMLI, AHMET ADİL; AYDIN, TEOMAN; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNThe aim of this study is to evaluate myeloperoxidase activity, catalase activity and thiol levels at early with rheumatoid arthritis patients. Blood taken from the patients was diagnosed with RA according to American Rheumatism Association ACR 2010 criteria, but not employed the medication of DMARD (Disease-modifying antirheumatic drugs) in order to examine the antioxidant parameters of myeloperoxidase activity, catalase activity and thiol levels. Twenty nine patients with early RA and 61 healthy controls were included in the study. Peripheral blood samples were used for all the assays. The average age of the patients was 39.91 +/- 13.32 and their average BMI was 28.56 +/- 4.15. Erytrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values have been found significantly high levels in RA group when we compare with control group. Catalase activity and thiol levels which means antioxidant parameters, have been found significantly low levels according to control group. When the parameters of myeloperoxidase activity were compared to the control group, the values of control group were significantly high. Stronger response in patients with early RA suggests that antioxidant markers may be useful in evaluating the progression of RA as well as in elucidating the mechanisms of disease pathogenesis.Publication Metadata only ASSESSMENT OF PARAOXONASE AND ARYLESTERASE ANTIOXIDATIVE PARAMETERS IN RHEUMATIC DISEASES(2016-01-01) Keskin, YAŞAR; Aydin, TEOMAN; TAŞPINAR, ÖZGÜR; KEPEKÇİ, MÜGE; Ozer, O. F.; Selek, S.; Camli, AHMET ADİL; Mutluer, A. S.; KESKİN, YAŞAR; AYDIN, TEOMAN; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN; ÇAMLI, AHMET ADİLThe aim of this study is to evaluate the patient stress markers which has the early stage rheumatoid arthritis (RA). Blood samples were collected from the patients diagnosed with rheumatoid arthritis according to American Rheumatism Association ACR 2010 criteria, but not employed the medication of DMARD (Disease-modifying antirheumatic drugs) in order to examine the stress parameters of total oxidant status, total antioxidant status, paraoxonase, paraoxonase NaCl, arylesterase concentration. Twenty nine patients diagnosed with early stage RA and 61 healthy control group included in the study. Peripheral blood samples were examined for all the assays. The average age of the patients was 39.91 +/- 13.32 and their average BMI was 28.56 +/- 4.15. ESR and CRP values have been found significantly high levels in RA group when we compare with control group. OSI values, which means oxidant parameters, have been found significantly high compared to the control group. When the parameters of arylesterase were compared to the control group, the values of control group were significantly high.Publication Metadata only Oxidative stress and phenotype frequencies of paraoxonase-1 in teratozoospermia.(2019-04-22) AKBULUT, H; Ozer, OF; GULER, ERAY METİN; CAGLAR, HİFA GÜLRU; GEVHER, FATİH; KOKTASOGLU, FATMANUR; SELEK, S; ÖZER, ÖMER FARUK; AKBULUT, HABİB; GÜLER, ERAY METİN; ÇAĞLAR, HİFA GÜLRU; GEVHER, FATİH; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİNOxidative stress causes infertility in men by affecting especially sperm morphology. The aim of the study was to examine the frequencies of paraoxonase-1 (PON1) phenotypes and the serum PON1, arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, catalase and thiol levels in teratozoospermic infertile men and normospermic fertile men. The study included 184 teratozoospermic infertile men and 72 normospermic fertile men. The double substrate method was employed to determine the phenotype distribution of PON1. The evaluation of sperm morphology was made in accordance with the Kruger-s criteria. TAS, catalase and thiol levels were determined to be significantly lower in teratozoospermic infertile men compared to normospermic fertile men. A significant change was not observed in the levels of TOS, PON1 and arylesterase. There was a positive correlation between catalase and thiol levels and sperm morphology. While there were significantly more teratozoospermic men with AA phenotypes compared to normospermic men, there were significantly more persons with AB and BB phenotypes in normospermic men than in teratozoospermic men. As far as we know, such a study was conducted for the first time and suggests that PON1 phenotypic distribution may play a significant role in sterile males because of impaired sperm morphology.