Person: ÖZER, ÖMER FARUK
Loading...
Status
Email Address
Birth Date
Name
Job Title
First Name
ÖMER FARUK
Last Name
ÖZER
Organizational Units
19 results
Search Results
Now showing 1 - 10 of 19
Publication Open Access Comparison of the biochemical and radiological criteria for lumbar disc degeneration(2018-09-01) Seyithanoglu, MEHMET HAKAN; Kitis, SERKAN; Ozer, Omer Faruk; Kocyigit, ABDÜRRAHİM; DÜNDAR, Tolga; Papaker, Meliha Gundeg; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMBackground: The relationship between radiological degeneration criteria on lumbar magnetic resonance imaging (MRI) and both the keratan sulfate (KS) and chondroitin sulfate (ChS) levels was examined in disc material taken from patients undergoing lumbar disc herniation (LDH) surgery. To examine whether the biochemical and radiological degeneration criteria testing the reliability of radiological degeneration findings agreed and to evaluate the contribution of the KS/ChS ratio to disc form (protruding or extruding).Publication Metadata only Comparison of serum thiol-disulphide homeostasis and total antioxidant-oxidant levels between exudative age-related macular degeneration patients and healthy subjects(2017-10-01) Elbay, AHMET; Ozer, Omer Faruk; AKKAN, Julide Canan Umurhan; Celik, Ugur; KUTLUTURK, Isil; Koytak, Arif; OZDEMIR, Hakan; ELBAY, AHMET; ÖZER, ÖMER FARUK; KOYTAK, İBRAHİM ARİF; ÖZDEMİR, MEHMET HAKANThe purpose of the study was to calculate serum total oxidant status (TOS), total antioxidant status (TAS), and dynamic thiol-disulphide (T-D) homeostasis in patients with age-related macular degeneration (AMD), and compare the results with healthy individuals.Publication Metadata only The Diagnostic Value of SCUBE1 in Unstable Angina Pectoris Patients(2016-12-01) OZKAN, Abuzer; Sonmez, ERTAN; OZDEMIR, Serdar; Ozer, Omer Faruk; MUHARREM, Nasifov; Gulen, BEDİA; KESKIN, Muhammed; SÖNMEZ, ERTAN; ÖZER, ÖMER FARUK; GÜLEN, BEDİAAim: Signal peptide complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor-like domain-containing protein 1 (SCUBE1) has been used in research as a biomarker in acute coronary syndrome (ACS). The aim of this study is to determine if SCUBE1 and routine laboratory parameters are effective in distinguishing the patients presenting with clinical symptoms of unstable angina pectoris (USAP) from the patients who have non-ST-segment elevated myocardial infarction (NSTEMI) and non-cardiac chest pain patients (NCCP).Publication Open Access Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks(2018-01-01) YIGIT, Mehmet; SOGUT, Ozgur; TATAROGLU, Ozlem; YAMANOGLU, Adnan; YIGIT, Eda; Guler, ERAY METİN; Ozer, Omer Faruk; Kocyigit, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMBackground: The present study investigated the potential roles of plasma lymphocyte DNA damage, the urotensin-2 receptor (UTS2R), and oxidative changes in patients with varying degrees of migraine-related disability who were in the ictal phase and presented to our emergency department. Methods: This study enrolled 40 consecutive adult patients with migraine attack and 40 age- and sex-matched healthy controls. The same health care professional determined the headache-related disability of each patient’s migraine attack using the Migraine Disability Assessment Scale (MIDAS); patients were divided into three groups based on MIDAS score. Plasma lymphocyte DNA damage; UTS2R, malondialdehyde (MDA), and catalase (CAT) levels; total oxidant status (TOS); total antioxidant status (TAS); and the oxidative stress index (OSI) were used as predictors of early oxidative changes. Results: Plasma lymphocyte DNA damage, TOS, MDA levels, and OSI values were significantly higher in patients with migraine compared to controls. Conversely, TAS and CAT and UTS2R levels were markedly lower in patients with migraine compared to controls. Comparisons of the patient groups by MIDAS score revealed significant differences in plasma lymphocyte DNA damage and CAT levels but no differences in TOS, MDA levels, OSI, TAS, or UTS2R levels. MIDAS scores were positively correlated with the degree of lymphocyte DNA damage, but neither of these factors was significantly related to CAT levels. Conclusion: The present data suggest that lymphocyte DNA damage and changes in oxidative/ antioxidative status may reflect an enhanced oxidative damage and an ineffective antioxidant defense system in migraineurs during headache attacks. In addition, lymphocyte DNA damage levels may be an indicator of the degree of migraine-related disability as assessed by MIDAS score.Publication Metadata only The predictive value of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) in terms of the duration of peripheral ischemia and exposure to reperfusion(2017-01-01) SÖĞÜT, Ozgur; Sonmez, ERTAN; YIGIT, Mehmet; Turkdogan, Kenan Ahmet; KUCUKDAGLI, Okkes Taha; YİĞİT, Eda; Ozer, Omer Faruk; CİVELEK, Cemil; SÖNMEZ, ERTAN; ÖZER, ÖMER FARUKBiomarkers play important roles in the diagnosis and follow-up of ischemic diseases. This study investigated the predictive value of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) in rats with peripheral ischemia that were subjected to reperfusion. Forty rats were divided into five equal groups as follows (eight rats per group): a control group (to determine the basal levels of the markers), three ischemia groups (groups 1-3), and a reperfusion group (group 4). There were no significant differences in SCUBE1 levels between the control and ischemia groups. However, the SCUBE1 level was markedly higher in the reperfusion group than in the control and ischemia groups (p<0.05). The results indicate that SCUBE1 levels are not biomarkers of the induction of ischemia. However, they are potentially markers of reperfusion in rats with acute peripheral occlusions.Publication Open Access Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters(2016-01-01T00:00:00Z) Vehapoglu, AYSEL; TURKMEN, Serdar; GOKNAR, Nilufer; Ozer, Omer Faruk; VEHAPOĞLU TÜRKMEN, AYSEL; ÖZER, ÖMER FARUKObjective: There are associations between some inflammatory and oxidative markers and obesity in adults, but whether prepubescent children of different weights also have such markers has not been studied. We investigated multiple inflammatory markers and levels of erythrocyte oxidant/antioxidant enzymes in prepubescent children of different weights.Publication Metadata only Effects of Cichorium Intybus Extract on Seizure Development, Bcl-2, Siklin B1 ve beta-Tubulin Levels in Pentylenetetrazole-Kindling Model of Epilepsy in Rats(2015-09-01) Erkeç, Özlem Ergül; Meral, Ismail; Kara, Mehmet; Kocyigit, ABDÜRRAHİM; Armagan, Metin; Ozer, Omer Faruk; MERAL, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; ÖZER, ÖMER FARUKPublication Metadata only Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin-Proteosome System in Autism Spectrum Disorder?(2017-09-01T00:00:00Z) Cetin, Ihsan; Tezdig, Ihsan; TARAKCLOGLU, Mahmut Cem; Kadak, Muhammed Tayyib; Demirel, Omer Faruk; Ozer, Omer Faruk; Erdogan, Firat; Dogangun, Burak; ÖZER, ÖMER FARUKIntroduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system.Publication Metadata only Low Serum Level alpha-Synuclein and Tau Protein in Autism Spectrum Disorder Compared to Controls(2015-12-01T00:00:00Z) Kadak, Muhammed Tayyib; Cetin, Ihsan; TARAKCIOGLU, Mahmut Cem; Ozer, Omer Faruk; Kacar, Selma; ÇİMEN, Behzat; ÖZER, ÖMER FARUKalpha-Synuclein (alpha-syn) and tau proteins are thought to be related with the synaptic loss and cell death underlying several important neurodegenerative diseases. The aim of our study was to investigate serum alpha-syn and tau levels in autism. Serum levels of alpha-syn and tau were measured, and autism spectrum disorder (ASD) severity was assessed at admission using the Childhood Autism Rating Scale (CARS) total score. The mean CARS score of the autism group on admission was 47.91 points (SD: 5.97). The results indicated that the mean serum alpha-syn and serum tau levels were significantly (p < 0.001) lower in children with ASD as compared with normal cases (33.01 +/- 20.78 and 55.19 +/- 15.34 ng/mL and 241.23 +/- 290.5 and 509.78 +/- 269.25 ng/mL, respectively). There was a significant positive correlation between seruma-syn levels and serum levels of tau identified by Pearson correlation analysis (r = 0.922, n = 28, p < 0.001). Synaptic abnormality in autism may result from microglial activity. Furthermore, alpha-syn and tau aggregation may lead to synaptic dysfunction, and this may contribute to either neuronal or synaptic dysfunction or neurodegeneration. Our preliminary study suggests that low levels of serum alpha-syn and tau may be implicated in the relationship between synaptic activity and autism.Publication Open Access An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats(2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUKObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.