Person: SÖNMEZ, FATMA CAVİDE
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Publication Open Access Vulvar granular cell tumor(2016-07-01) Sonmez, FATMA CAVİDE; KOROGLU, Nadiye; Guler, BERİL; Arici, DİLEK SEMA; SÖNMEZ, FATMA CAVİDE; GÜLER, BERIL; ARICI, DILEK SEMAGranular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. They generally occur as small, slow growing, and skin-colored nodule. GCTs are usually benign, but malignant cases were reported. Recurrence can be seen in benign tumors with clear margins, but rates increase with positive margins. The treatment is complete surgical excision. We report a case of benign GCT of the vulva. A 41-year-old patient presented with vulvar mass, and biopsy was consisted with GCT.Publication Open Access Cotyledonoid Dissecting Leiomyoma with Symplastic Features: Case Report.(2017-08-01) SONMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; KARASU, AFG; Arıcı, DİLEK SEMA; DANSUK, RAMAZAN; SÖNMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; DANSUK, RAMAZANForeign bodies are rare and challenging issues leading to symptoms according to the location. Laparoscopy is a popular and minimally invasive method used for removal of foreign bodies in the abdominal cavity or retroperitoneum. We herein report a case with retroperitoneal foreign body that was removed through retroperitoneal single- port laparoscopy using nephroscope. To our knowledge this is the first case of removal of a retroperitoneal foreign body through single- port laparoscopy using nephroscope.Publication Open Access New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.(2016-12-01) AKTHSR, Muhammad Salman; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; TANRIKULU, MEHMET AKİF; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAY; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAYBACKGROUND Current research investigating the role of THBS2 and LECT-2 in atherogenesis is very limited. Therefore, we designed this study to demonstrate the role of THBS-2 and LECT-2 in atherosclerosis at the tissue level in fresh specimens. MATERIAL AND METHODS A total of 32 patients who underwent coronary bypass surgery were enrolled. Aortic wall punch biopsies were obtained at the site of proximal aortosaphenous bypass graft anastomosis. A specimen of left internal mammarian artery (LiMA) was taken from the segment just proximal to its anastomosis. The aortic tissue is representive of the atherosclerotic tisue, and LiMA tissue is representative of the non-atherosclerotic area. The specimens were painted with CD68 for macrophage, and THBS-2 and LECT-2 antibodies for immunohistochemical staining. RESULTS Aortic THBS-2 levels were significantly lower, whereas aortic LECT-2 levels were significantly higher when compare to LiMA (14.4±9.9 (5-30) and 36.9±13.0 (5-60) p: 0.0001 and 20.3±15.0 (5-60) and 20.8±13,8 (10-30) p: 0.0001, respectively). CD68+ and monocyte level correlated significantly with AHA atherosclerosis grade (p=0.01, r=0.45 and p=0.001, r=0.56, Spearman's test). CD68+ level correlated significantly with LECT-2 levels in atherosclerotic aortic tissue (p=0.026, r=0.392, Spearman's test), whereas aortic TSBN-2 levels were not. CONCLUSIONS The present study has taken the first steps to highlight new markers in atherosclerosis by using immunohistochemical method. The study results suggest that the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis.Publication Open Access Immunoexpression of TTF-1 in Non-Lung Tumors(2014-12-01T00:00:00Z) TOSUNER, ZEYNEP; ARICI, Dilek Sema; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİNObjective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors. Methods: A total of 85 cases that were diagnosed in our institute between the years 2011-2012 were included in our study. After a review of the pathological slides prepared from these tumors [colon adenocarcinoma (n: 15), renal cell carcinoma (n: 15), prostate adenocarcinoma (n: 15), invasive papillary urothelial carcinoma (n: 15), invasive ductal carcinoma of breast (n: 15), and neuroendocrine tumors (n: 10)] TTF-1 immunohistochemistry was applied. Semiquantative evaluation based on the distribution and intensity of the staining was performed by two pathologists, respectively. Results: Positive immunostaining was evident in only 1 case of colon adenocarcinoma out of 85 cases. Conclusion: Our study demonstrated that TTF-1 immunoexpression is a very rare finding (1%) in non-lung tumors. This result provides that anti-TTF-1 is a reliable antibody in the interpretation of primary lung carcinomas. In fact, further studies with a large number of cases are needed to confirm the sensitivity and specificity of TTF-1.Publication Open Access Carcinoid tumor arising in a mature cystic teratoma: A case report(2015-05-01) Tosuner, ZEYNEP; Sonmez, FATMA CAVİDE; Arici, DİLEK SEMA; Dansuk, RAMAZAN; TOSUNER, ZEYNEP; SÖNMEZ, FATMA CAVİDE; ARICI, DILEK SEMA; DANSUK, RAMAZANMature cystic teratomas are common benign tumors of the ovary. The most common form of malig‑ nant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoac‑ tive substances produced by the tumor. A 75‑year‑old woman suffering from groin pain was admitted to the Faculty of Medi‑ cine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7‑cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow‑up examinationsPublication Open Access Hamartoma of the breast in two patients: A case report(2013-08-01T00:00:00Z) Sonmez, FATMA CAVİDE; Gucin, ZÜHAL; Yildiz, PELİN; Tosuner, ZEYNEP; SÖNMEZ, FATMA CAVİDE; GÜCİN, ZÜHAL; YILDIZ, PELİN; TOSUNER, ZEYNEPBreast hamartomas are rare, benign, tumor-like nodules composed of glandular, adipose and fibrous tissue. The hamartoma was first described in 1971 as a lipofibroadenoma, fibroadenolipoma or adenolipoma, based on the predominant component of the breast tissue. Clinical findings resemble fibroadenoma and if there is a palpable mass, the patients may receive an immediate diagnosis. Ductal hyperplasia, apocrine metaplasia, calcification and adenosis may occur within the hamartoma, with rarer instances of lobular or ductal intraepithelial neoplasms. Although hamartoma is usually benign, a malignant transformation is possible. An excision and histological examination is necessary for the differential diagnosis and also for any epithelial lesions of the hamartoma. Simple excision is enough for treatment if there is no coincidental epithelial malignant lesion. The patients in the present study were treated by simple excision as there were no proliferative changes in the lesions. No recurrence or other problems were detected in the 18-month follow-up. The current study presents two cases of breast hamartoma that were diagnosed as an adenolipoma and a fibroadenolipoma, and then describes the macroscopic and microscopic observations of these lesions.Publication Open Access Radiological Appearences of Benign Soft-tissue Tumors of the Hand and Wrist with Special Emphasis on NRI(2022-04-01T00:00:00Z) YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; Atasoy, Bahar; SÖNMEZ, FATMA CAVİDE; ARALAŞMAK, Ayşe; GÜRKAN, Volkan; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; ATASOY, BAHAR; SÖNMEZ, FATMA CAVİDE; ARALAŞMAK, AYŞE; GÜRKAN, VOLKANTumoral and pseudotumoral lesions of the hand and wrist are commonly encountered in routine clinical practice. Although most of them arc benign, radiological differential diagnosis of these lesions is difficult, because of their nonspecific imaging findings, except ganglia, localized type of tenosynovial giant cell tumors and lipomas. Digital radiography, computed tomography, and ultrasound may be useful in identification of the lesions in the wrist and hand, but magnetic resonance imaging with superior contrast and spatial resolution is the most important imaging modality.Publication Open Access General Overview of Renal Cell Carcinoma with the Evaluation of our cases(2015-12-01) Yildiz, PELİN; Sonmez, FATMA CAVİDE; Buyukpinarbasili, NUR; Gucin, ZÜHAL; Arici, DİLEK SEMA; KOCAKOC, Ercan; Akcay, MUZAFFER; YILDIZ, PELİN; SÖNMEZ, FATMA CAVİDE; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ARICI, DILEK SEMA; AKÇAY, MUZAFFERObjective: Renal cell carcinoma (RCC) is the 14th most common tumor in the world. In 2010, the protocol for the examination of kidney specimens with invasive carcinoma of renal tubular origin was updated. The aim of our study was to review 1-year RCC patients of our hospital according to the new protocol, classification, and staging systems with respect to their morphological and immunohistochemical features.. Methods: The medical records of 54 RCC patients between July 2012 and July 2013 were retrospectively reviewed. They were classified according to the WHO 2004 classification system and newly defined subtypes. The following variables were determined in each case: age, sex, histological subtype, stage, and Fuhrman nuclear grade. Results: In our study, 30 (55.6%) men and 24 (44.4%) women were diagnosed with RCC out of 54 patients. The median age was 56 years. In total, 21 patients had (55.2%) right-and 17 had (44.74%) left-sided tumors. Thirty-eight (70.3%) clear cell, 6 (11.1%) papillary, 7 (12.96%) chromophobe, 1 (1.85%) multilocular, 1 (1.85%) unclassified, and 1 (1.85%) tubulocystic RCC were seen. According to primary tumor, 33 (61.1%) pT1, 10 (18.51%) pT2, 9 (16.66%) pT3, and 2 (3.70%) pT4 patients were reported. Chromophobe RCCs were excluded from the Fuhrman grading (G) system; of the remaining 2 (4.17%) were G1, 30 (62.5%) were G2, 13 (27.08%) were G3, and 3 (6.25%) were G4 tumors. Conclusion: Although RCC constitutes the majority of renal tumors, different subtypes are also encountered. In our study, clear cell RCCs were the most common type of tumors consistent with the literature. The remarkable point was that chromophobe RCCs were more frequent in our study. Because of infrequency, more examples are required to distinguish newly defined subtypes.