Person: SÖNMEZ, FATMA CAVİDE
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Publication Open Access Vulvar granular cell tumor(2016-07-01) Sonmez, FATMA CAVİDE; KOROGLU, Nadiye; Guler, BERİL; Arici, DİLEK SEMA; SÖNMEZ, FATMA CAVİDE; GÜLER, BERIL; ARICI, DILEK SEMAGranular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. They generally occur as small, slow growing, and skin-colored nodule. GCTs are usually benign, but malignant cases were reported. Recurrence can be seen in benign tumors with clear margins, but rates increase with positive margins. The treatment is complete surgical excision. We report a case of benign GCT of the vulva. A 41-year-old patient presented with vulvar mass, and biopsy was consisted with GCT.Publication Open Access Cotyledonoid Dissecting Leiomyoma with Symplastic Features: Case Report.(2017-08-01) SONMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; KARASU, AFG; Arıcı, DİLEK SEMA; DANSUK, RAMAZAN; SÖNMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; DANSUK, RAMAZANForeign bodies are rare and challenging issues leading to symptoms according to the location. Laparoscopy is a popular and minimally invasive method used for removal of foreign bodies in the abdominal cavity or retroperitoneum. We herein report a case with retroperitoneal foreign body that was removed through retroperitoneal single- port laparoscopy using nephroscope. To our knowledge this is the first case of removal of a retroperitoneal foreign body through single- port laparoscopy using nephroscope.Publication Metadata only Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?(2016-12-01) Guler, BERİL; Kiran, TUĞÇE; Arici, DİLEK SEMA; Aysan, Erhan; Sonmez, FATMA CAVİDE; GÜLER, BERIL; KIRAN, TUĞÇE; ARICI, DILEK SEMA; AYŞAN, MUSTAFA ERHAN; SÖNMEZ, FATMA CAVİDEFine needle aspiration (FNA) is the first choice in thyroid nodules suspected of harboring malignancy on sonography in routine practice. However, sampling with core needle biopsy (CNB) is also being used, especially in cases with repeated nondiagnostic/indeterminate diagnoses. The aim of this study was the retrospective evaluation of CNB samples. A total of 604 thyroid CNB samples registered in the Department of Pathology at Bezmialem Foundation University Medical Faculty within the 1-year period between June 2014 and June 2015 were re-evaluated by correlation with previous FNA and later resection results. CNB was divided into diagnostic groups of insufficient, malignant, suspicious for malignancy, no evidence of malignancy/benign, atypia of uncertain significance (AUS)/follicular lesions of uncertain significance (FLUS), and follicular neoplasm (FN)/suspicious for follicular neoplasm (SFN). Among the 604 cases, 15 cases (2.48 %) were classified as malignant and 9 cases (1.49 %) as suspicious for malignancy. No evidence of malignancy was seen in 512 cases (84.76 %). There were 26 (4.3 %) cases in the AUS/FLUS-FN/SFN group, and the sample was inadequate in 42 cases (6.95 %). Resection was performed for 17 of the cases classified as malignant or suspicious for malignancy, and all were found to be malignant. There were also 10 resected cases with a diagnosis of no evidence of malignancy, and all were found to be benign. We think that sampling with CNB may be useful especially in repeating inadequate biopsies or cases diagnosed with AUS/FLUS that have hesitations regarding clinical management. Larger series including comparisons with FNA and resection results are required.Publication Open Access Immunoexpression of TTF-1 in Non-Lung Tumors(2014-12-01T00:00:00Z) TOSUNER, ZEYNEP; ARICI, Dilek Sema; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİNObjective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors. Methods: A total of 85 cases that were diagnosed in our institute between the years 2011-2012 were included in our study. After a review of the pathological slides prepared from these tumors [colon adenocarcinoma (n: 15), renal cell carcinoma (n: 15), prostate adenocarcinoma (n: 15), invasive papillary urothelial carcinoma (n: 15), invasive ductal carcinoma of breast (n: 15), and neuroendocrine tumors (n: 10)] TTF-1 immunohistochemistry was applied. Semiquantative evaluation based on the distribution and intensity of the staining was performed by two pathologists, respectively. Results: Positive immunostaining was evident in only 1 case of colon adenocarcinoma out of 85 cases. Conclusion: Our study demonstrated that TTF-1 immunoexpression is a very rare finding (1%) in non-lung tumors. This result provides that anti-TTF-1 is a reliable antibody in the interpretation of primary lung carcinomas. In fact, further studies with a large number of cases are needed to confirm the sensitivity and specificity of TTF-1.Publication Open Access Carcinoid tumor arising in a mature cystic teratoma: A case report(2015-05-01) Tosuner, ZEYNEP; Sonmez, FATMA CAVİDE; Arici, DİLEK SEMA; Dansuk, RAMAZAN; TOSUNER, ZEYNEP; SÖNMEZ, FATMA CAVİDE; ARICI, DILEK SEMA; DANSUK, RAMAZANMature cystic teratomas are common benign tumors of the ovary. The most common form of malig‑ nant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoac‑ tive substances produced by the tumor. A 75‑year‑old woman suffering from groin pain was admitted to the Faculty of Medi‑ cine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7‑cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow‑up examinations