Person: KORKMAZ, NUR DAMLA
9 results
Search Results
Now showing 1 - 9 of 9
Publication Blefarospazm Olgularinda miRNA Alt Tipleri Ekspresyon Düzeylerinin İncelenmesi ve Aday Biyobelirteç Tayini(2024-01-01) Yaman Kula A.; Korkmaz N. D.; Düzenli Ö. F.; Yozlu M.; Kaya Güleç Z. E.; Yabacı Tak A.; Toruntay C.; Süsgün S.; Genç G.; Savrun F.; et al.; YAMAN KULA, ASLI; KORKMAZ, NUR DAMLA; YABACI TAK, AYŞEGÜL; SÜSGÜN, SEDA; MATUR, ZELİHAss1Publication What Inflammasomes Tell Us About Multiple Sclerosis(2021-06-04T00:00:00Z) Hocaoğlu, Nisa; Gürsoy, Azize Esra; Elibol, Birsen; Korkmaz, Nur Damla; Karakayali, Zehra Cemre; GÜRSOY, AZIZE ESRA; ELİBOL, BİRSEN; KORKMAZ, NUR DAMLAPublication Atak ve iyileşmelerle giden multiple skleroz hastalığında inflamazomların değerlendirilmesi(2021-10-29T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; Gürsoy, Azize Esra; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN; GÜRSOY, AZIZE ESRAPublication Moleküler Biyoloji Güncel Araştırma Teknikleri(2022-04-01T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; KORKMAZ, NUR DAMLA; ELİBOL, BİRSENPublication Fumaraz enziminin Shewanella putrefaciens bakterisinden üretimi ve biyokimyasal tanı kitlerinde kullanılması(2021-10-31T00:00:00Z) Toruntay, Ceyhun; Korkmaz, Nur Damla; Selek, Şahabettin; Gül, Ayşe Zehra; Demirel, Metin; Sarıkaya, Ufuk; Akbaş, Fahri; TORUNTAY, CEYHUN; KORKMAZ, NUR DAMLA; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; DEMİREL, METİN; AKBAŞ, FAHRİPublication Eksüdatif yaşa bağlı makula dejenerasyonunun etiyopatogenezinin aydınlatılması amacıyla ARPE-19 hücre hattında CoCl2 ile indüklenen hipoksi modeli oluşturulması(2021-10-31T00:00:00Z) Süsgün, Seda; Korkmaz, Nur Damla; Kutlutürk, Işıl; Akbaş, Fahri; Özdemir, Mehmet Hakan; Elbay, Ahmet; SÜSGÜN, SEDA; KORKMAZ, NUR DAMLA; AKBAŞ, FAHRİ; ÖZDEMİR, MEHMET HAKAN; ELBAY, AHMETPublication Genetik jeneralize epilepside miRNA'ların genetik biyobelirteçler olarak değerlendirilmesi(2023-12-31) Bozkurt S.; Korkmaz N. D.; Bilge B. N.; Yabacı Tak A.; Bayrakoğlu A.; Uslu İlgen F.; Yücesan E.; Akbaş F.; KORKMAZ, NUR DAMLA; YABACI TAK, AYŞEGÜL; AKBAŞ, FAHRİEvaluation of miRNAs as genetic biomarkers in genetic generalized epilepsySimay Bozkurt1, Nur Damla Korkmaz2, Bilge Nur Bilge3, Aysegul Yabaci Tak4, Alisan Bayrakoglu5, Ferda Uslu Ilgen5, Emrah Yucesan6, Fahri Akbas1,21Bezmialem Vakif University, Institute of Health Sciences, Department of Biotechnology, Istanbul, Türkiye.2Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Türkiye.3Istanbul University-Cerrahpasa, Institute of Neurological Sciences, Department of Neuroscience, Istanbul, Türkiye.4Bezmialem Vakif University, Faculty of Medicine, Department of Basic Medical Sciences, Department of Biostatistics and Medical Informatics, Istanbul, Türkiye.5Bezmialem Vakif University, Faculty of Medicine, Department of Neurology, Istanbul, Türkiye.6Istanbul University-Cerrahpasa, Institute of Neurological Sciences, Department of Neurogenetics, Istanbul, Türkiye.Objective: Genetic generalized epilepsy (GGE) is a subtype of epilepsy that involves the entire brain and has a genetic etiology. GGE accounts for 15-20% of all epilepsies. There is no specific genetic biomarker widely used that contributes to the diagnostic process of this disease. In the last decade, there has been a radical increase in the number of studies on the use of small non-coding RNAs found in the human genome as genetic biomarkers for various neurological diseases. MicroRNAs (miRNAs), the best-known small non-coding RNAs, play a critical role in regulating neuronal biological processes through the modulation of gene expression. Therefore, miRNAs have assumed an important role in biomarker research due to their stability in clinical samples. In our study, we examined the expression levels of miR-106b, miR-130a-3p, and miR-194-5p in GGE patients with the aim of evaluating their performance as diagnostic biomarkers.Methods: 21 patients with isolated GGE and 18 healthy controls were recruited in this study and total RNA was extracted from blood samples of participants. cDNA synthesis was performed from the obtained RNAs. The expression levels of miR-106b, miR-130a-3p and miR-194-5p were analyzed via qRT-PCR, and receiver operating characteristic (ROC) curves were generated and area under the curve (AUC) was calculated to evaluate the diagnostic values.Results: The expression level of miR-130a-3p has shown statistically significant increase in patients compared to controls (p<0.05). The AUC value determined in the ROC analysis is 0.725. However, the expression levels of miR-106b and miR-194-5p are not detected statistically significant. Their AUC values in the ROC analysis are 0.648 and 0.571, respectively.Conclusion: The varying expression levels of miRNAs that we used in our study may be associated with the etiopathogenesis of GGE. Our findings suggest using miR-130a-3p as potential biomarker in the diagnosis and prognosis of GGE.Keywords: Genetic biomarker, genetic generalized epilepsy, microRNA, ROC curve.Acknowledgement: This study was supported by Bezmialem Foundation University, Scientific Research Projects Unit (Project no: 20230205).29Objective: Genetic generalized epilepsy (GGE) is a subtype of epilepsy that involves the entire brain and has a genetic etiology. GGE accounts for 15-20% of all epilepsies. There is no specific genetic biomarker widely used that contributes to the diagnostic process of this disease. In the last decade, there has been a radical increase in the number of studies on the use of small non-coding RNAs found in the human genome as genetic biomarkers for various neurological diseases. MicroRNAs (miRNAs), the best-known small non-coding RNAs, play a critical role in regulating neuronal biological processes through the modulation of gene expression. Therefore, miRNAs have assumed an important role in biomarker research due to their stability in clinical samples. In our study, we examined the expression levels of miR-106b, miR-130a-3p, and miR-194-5p in GGE patients with the aim of evaluating their performance as diagnostic biomarkers.Methods: 21 patients with isolated GGE and 18 healthy controls were recruited in this study and total RNA was extracted from blood samples of participants. cDNA synthesis was performed from the obtained RNAs. The expression levels of miR-106b, miR-130a-3p and miR-194-5p were analyzed via qRT-PCR, and receiver operating characteristic (ROC) curves were generated and area under the curve (AUC) was calculated to evaluate the diagnostic values.Results: The expression level of miR-130a-3p has shown statistically significant increase in patients compared to controls (p<0.05). The AUC value determined in the ROC analysis is 0.725. However, the expression levels of miR-106b and miR-194-5p are not detected statistically significant. Their AUC values in the ROC analysis are 0.648 and 0.571, respectively.Conclusion: The varying expression levels of miRNAs that we used in our study may be associated with the etiopathogenesis of GGE. Our findings suggest using miR-130a-3p as potential biomarker in the diagnosis and prognosis of GGE.Keywords: Genetic biomarker, genetic generalized epilepsy, microRNA, ROC curve.Acknowledgement: This study was supported by Bezmialem Foundation University, Scientific Research Projects Unit (Project no: 20230205).29Publication Comparison of Gut Microbiota in Patients of Mild-Cognitive Impairment and Alzheimer’s Diseasewith Age and Sex Matched Normal Controls: A Multicenter Study(2018-07-26T00:00:00Z) Sezgin, Betül; Nalbantoğlu, Özkan Ufuk; Koç, Fatma; Gündoğdu, Aycan; Göl, Mehmet Fatih; Hanoğlu, Lütfü; Köseoğlu, Emel; Velioğlu, Halil Aziz; Yıldırım, Süleyman; Korkmaz, Nur Damla; KORKMAZ, NUR DAMLAPublication Effects of ketogenic diet on rat model of sporadic Azheimer’s Disease(2022-03-14T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN