Person: İNAL, EBRAR
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Alzheimer Hastalığı ve Doğal Kaynaklı Bileşikler
2021-12-01T00:00:00Z, Ulusoy, Şeyma, Kartal, Murat, İnal, Ebrar, ULUSOY, ŞEYMA, KARTAL, MURAT, İNAL, EBRAR
Bitkisel Droglarda Kalite Kontrol
2022-10-01, Kartal M., Ulusoy Ş., İnal E., KARTAL, MURAT, ULUSOY, ŞEYMA, İNAL, EBRAR
Variations in Chemical Compositions and Biological Activities of Artemisia vulgaris L. (Common Mugwort) Essential Oils at Different Growth Stages
2022-06-01T00:00:00Z, Demirbolat, İlker, İnal, Ebrar, Ulusoy, Şeyma, Kartal, Murat, İNAL, EBRAR, ULUSOY, ŞEYMA, KARTAL, MURAT
Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities
2023-12-01, İnal E., Nath E. Ö., Abudayyak M., Ulusoy Ş., İnan H. A., Cicek M., Kartal M., İNAL, EBRAR, ULUSOY, ŞEYMA, KARTAL, MURAT
The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plantVitex agnus-castusL. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of theV. agnus-castusEO’sin-vitrocytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits ofV. agnus-castuswere analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of theV. agnus-castus. EOs extracted from Balıkesir region were defined as the \"α-pinene-1,8-cineole\" chemotype, while EOs extracted from İstanbul region were defined as the \"sabinene-1,8-cineole\" chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze thein-vitrocytotoxic effects of flowers. This study is also the first to show thein-vitrocytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC50 is about 4.68 µg/mL on the MCF7 cell line- than İstanbul regions, which might be attributed to the higher amount ofα-pinene, caryophyllene, and limonene content. Our results indicated that theV. agnus-castusEOs, which containα-pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.
Pektinin Kimyasal Yapısı, Özellikleri ve Ekonomik Önemi: Eczacılık ve Kozmetikte Kullanımı
2021-12-01T00:00:00Z, İnal, Ebrar, Kartal, Murat, Ulusoy, Şeyma, İNAL, EBRAR, KARTAL, MURAT, ULUSOY, ŞEYMA
DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS
2024-01-01, Esentürk-Güzel I., ALĞIN YAPAR E., Cavalu S., ŞEKER İ. T., İNAL E., KARTAL M., Koç R. Ç., Öztürk R. Y., Göksu F., Bölek S., et al., İNAL, EBRAR, KARTAL, MURAT
The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.