Person: BÜTÜN, BURCU
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BÜTÜN
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BURCU
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- PublicationMetadata onlyFatty acid content of Reseda lutea var. lutea with antioxidant potential.(2015-06-12) Ertaş, Abdülselam; Boğa, Mehmet; DİNCEL, DEMET; BÜTÜN, BURCU; Yeşil, Yeter; Soruhan, H.F.; TOPÇU, GÜLAÇTI; KUŞMAN, TUBA; DİNCEL, DEMET; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyAntioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada(2015-11-01) Butun, Burcu; Hatipoglu, Seda Damla; Dönmez, Ayşe; Topcu, Gülaçtı; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIThe methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), beta-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (beta-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes. Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.
- PublicationMetadata onlyPreparation of Some 3-Hydroxyflavone Derivatives with Their Antioxidant Activities.(2015-07-24) BÜTÜN, BURCU; KUŞMAN, TUBA; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; KUŞMAN, TUBA; TOPÇU, GÜLAÇTI
- PublicationMetadata onlySynthesis of 3-Hydroxyflavone Derivatives and Determination of their Antioxidant and Anticholinesterase Activities(2016-09-15) Öztürk, Turan; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyYeni Bromo İndenokinolinamin Türevlerinin Anti Alzhemier Ajanlar olarak Biyolojik Aktivitelerinin Değerlendirilmesi(2017-04-29) Ökten, Salih; Ekiz, Makbule; Tutar, ahmet; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyUrsolik Asitin Potansiyel Antikolinesteraz Türevlerinin Yarı Sentezi(2012-10-06) Hatipoğlu, Seda Damla; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyBioactive constituents of Salvia chrysophylla Stapf(2013-03-01T00:00:00Z) Butun, Burcu; Yapar, Gönül; Dirmenci, Tuncay; Topcu, Gulacti; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIThe dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated as sclareol, -sitosterol, salvigenin, oleanolic acid and ursolic acid. The lipid peroxidation inhibitory activity and the DPPH free radical scavenging activity of the pure isolates were investigated to establish their antioxidant potential. Their anticholinesterase activity was carried out by the Ellman assay against both enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase, and diterpene sclareol exhibited fairly good activity against both the enzymes while the two triterpenoids oleanolic and ursolic acids exhibited selective activity against AChE.
- PublicationMetadata onlyInvestigation of Anticholinesterase Activity of a Series of Salvia Extractsand the Constituents of Salvia staminea(2013-03-01) Topçu, Gülaçtı; Boğa, Mehmet; Kolak, Ufuk; Öztürk, Mehmet; Dirmenci, Tuncay; Bahadori, Fatemeh; Bütün, Burcu; TOPÇU, GÜLAÇTI; BAHADORİ, FATEMEH; BÜTÜN, BURCU
- PublicationMetadata onlyThe Search for Novel 3-hydroxyflavones with Anticholinergic Activity.(2015-06-16) Öztürk, Turan; Akdemir, ATİLLA; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; AKDEMİR, ATİLLA; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyTarget Recognition Molecules and Molecular Modeling Studies(2017-01-01) Bütün, Burcu; Akdemir, Atilla; BÜTÜN, BURCU; AKDEMİR, ATİLLA
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