Person: BÜTÜN, BURCU
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Publication Fatty acid content of Reseda lutea var. lutea with antioxidant potential.(2015-06-12) Ertaş, Abdülselam; Boğa, Mehmet; DİNCEL, DEMET; BÜTÜN, BURCU; Yeşil, Yeter; Soruhan, H.F.; TOPÇU, GÜLAÇTI; KUŞMAN, TUBA; DİNCEL, DEMET; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada(2015-11-01) Butun, Burcu; Hatipoglu, Seda Damla; Dönmez, Ayşe; Topcu, Gülaçtı; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIThe methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), beta-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (beta-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes. Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.Publication Preparation of Some 3-Hydroxyflavone Derivatives with Their Antioxidant Activities.(2015-07-24) BÜTÜN, BURCU; KUŞMAN, TUBA; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; KUŞMAN, TUBA; TOPÇU, GÜLAÇTIPublication Synthesis of 3-Hydroxyflavone Derivatives and Determination of their Antioxidant and Anticholinesterase Activities(2016-09-15) Öztürk, Turan; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication Investigation of Anticholinesterase Activity of a Series of Salvia Extractsand the Constituents of Salvia staminea(2013-03-01) Topçu, Gülaçtı; Boğa, Mehmet; Kolak, Ufuk; Öztürk, Mehmet; Dirmenci, Tuncay; Bahadori, Fatemeh; Bütün, Burcu; TOPÇU, GÜLAÇTI; BAHADORİ, FATEMEH; BÜTÜN, BURCUPublication The Search for Novel 3-hydroxyflavones with Anticholinergic Activity.(2015-06-16) Öztürk, Turan; Akdemir, ATİLLA; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; AKDEMİR, ATİLLA; TOPÇU, GÜLAÇTIPublication Ursolik Asitin Potansiyel Antikolinesteraz Türevlerinin Yarı Sentezi(2012-10-06) Hatipoğlu, Seda Damla; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication Yeni Bromo İndenokinolinamin Türevlerinin Anti Alzhemier Ajanlar olarak Biyolojik Aktivitelerinin Değerlendirilmesi(2017-04-29) Ökten, Salih; Ekiz, Makbule; Tutar, ahmet; BÜTÜN, BURCU; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication Doğal Stigmastan tipi steroidlerin MDA- MB-231 meme kanser soyu hücreler üzerine sitotoksik etkileri(2014-08-13) Türker Şener, Leyla; BÜTÜN, BURCU; Albeniz, Işıl; TOPÇU, GÜLAÇTI; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication Target Recognition Molecules and Molecular Modeling Studies(2017-01-01) Bütün, Burcu; Akdemir, Atilla; BÜTÜN, BURCU; AKDEMİR, ATİLLA
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