Person: YILDIZ, ŞEYMA
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Publication Metadata only Papillary Lesions of the Breast: Addition of DWI and TIRM Sequences to Routine Breast MRI Could Help in Differentiation Benign from Malignant(2022-01-01T00:00:00Z) GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMAAim: We aimed to investigate the magnetic resonance imaging (MRI) features of benign, atypical, or malignant papillary breast lesions and to assess the additional value of diffusion-weighted imaging (DWI) and turbo inversion recovery magnitude (TIRM) sequences to routine breast MRI. Background: Differentiation between benign and malignant papillary breast lesions is essential for patient management. However, morphologic features and enhancement patterns of malignant papillary lesions may overlap with those of benign papilloma. Methods: Seventy-two papillary breast lesions (50 benign, 22 atypical or malignant) were included in the current study, retrospectively. We divided the patients into two groups: benign papillary breast lesions and atypical or malignant papillary breast lesions. Morphologic, dynamic, turbo inversion recovery magnitude (TIRM) values and diffusion features of the papillary lesions were compared between two groups. Results: Benign papillary lesions were smaller in size (p=0.006 and p=0.005, for radiologists 1 and 2 respectively), closer to the areola (p=0.045 and 0.049 for radiologist 1 and 2 respectively), and had higher ADC values (p=0.001 for two radiologists) than the atypical or malignant group. ROC curves showed diagnostic accuracy for ADC (AUC=0.770 and 0.762, p & lt; 0.0001 for two radiologists), and showed a cut-off value of <= 957 x 10-6 mm(2/s) (radiologist 1) and <= 910 x 10-6 mm(2/s) (radiologist 2). Conclusion: MRI is a useful method for differentiation between benign and malignant papillary breast lesions. Centrally located, lesser in size, and higher ADC values should be considered benign, whereas peripherally located, larger in size, and lower ADC values should be considered malignant.Publication Open Access Comparison of MRI Features of Invasive Pleomorphic and Classical Lobular Carcinoma: Differentiation Is Possible?(2022-01-01T00:00:00Z) YILMAZ, TEMEL FATİH; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; GÜCİN, ZÜHAL; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA; YILMAZ, TEMEL FATİH; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; GÜCİN, ZÜHAL; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMATo evaluate breast MRI and DWI and demographic features of pleomorphic invasive lobular carcinoma (pILC) and classic invasive lobular carcinoma (cILC). Invasive lobular (ILC) is the second most common breast malignancy after invasive ductal carcinoma (IDC) and constitutes the 8-14% of all invasive breast cancers. ILC morphologically can be classified into the classic, alveolar, solid, tubulolobular, and pleomorphic subtypes according to WHO. This study was performed retrospectively. The MRI and demographic features of 18 patients with 23 pILC were compared with those 22 consecutive patients with 27 cILC. There was no significant difference in demographic features of patients, MR appearance, kinetics, and ADC values between two groups. pILC, an aggressive subtype of ILC, cannot be differentiated from cILC with breast MRI.Publication Metadata only Stem cell markers: A guide to neoadjuvant therapy in breast carcinomas(2022-06-01T00:00:00Z) Gücin, Zühal; Büyükpınarbaşılı, Nur; Geçer, Melin; Ersoy, Yeliz Emine; Türk, Hacı Mehmet; Yıldız, Şeyma; Aksoy, Direnç Özlem; GÜCİN, ZÜHAL; GEÇER, MELİN; ERSOY, YELIZ EMINE; TÜRK, HACI MEHMET; YILDIZ, ŞEYMABACKGROUND: In recent years, stem cells have been defined as the main cell population responsible for resistance to anticancer therapies. AIM: This study aims to investigate potential associations between the stem cell population and the degree of tumor regression in breast carcinomas treated with neoadjuvant therapy. SETTINGS AND DESIGN: The study included 92 patients with breast carcinoma who received neoadjuvant therapy. Tumor regression was defined based on Miller and Payne grading system. Patients with grade 1 or 2 regression on a 5‑point scale were included in group 1 (n = 37), grade 3 regression in group 2 (n = 32), and grade 4 or 5 regression in group 3 (n = 23). MATERIALS AND METHODS: Immunohistochemical staining was performed on paraffin block sections of every case using CD44, CD24, CD29, CD133, ID4, and ALDH1 antibodies to detect stem cells. STATISTICAL ANALYSIS USED: IBM Statistical Package for the Social Sciences (SPSS), version 23.0 (IBM Corp., Armonk, NY, USA) software was used for statistical analyses, and a P value less than 0.05 was considered statistically significant. RESULTS: Histologically high‑grade tumors are more common in the near‑complete/complete response group (P = 0.004). HER2‑positive tumors were more common in the complete/ near‑complete response group (P = 0.054). Tumor cells positive for stem cell markers CD44 and CD24 were more common in the poor response group (P = 0.027 and P = 0.001, respectively). CD29 expression was reduced in the posttreatment residual tumor tissue in the near‑complete/complete response group. CONCLUSION: High CD44 and CD24 expression may be a predictor of poor response/nonresponse to neoadjuvant therapy in breast carcinomas. KEY WORDS: Breast Cancers, neoadjuvant treatment, stem cell markers, stem cells, tumor regression gradePublication Metadata only Effect of quantitative and semi-quantitative elastography methods for management of borderline lesions on ultrasonography(2020-12-01T00:00:00Z) Aksoy, Direnç Özlem; Yıldız, Şeyma; Atasoy, Bahar; Kandemirli, Sedat Giray; Cingöz, Mehmet; YILDIZ, ŞEYMABackground: Elastography (strain or shear-wave) is a method that estimates tissue stiffness. Introduction: Our aim in this study to evaluate the quantitative and semi-quantitative ultrasound elastography methods for diagnosis of category BI-RADS 4a and BI-RADS 3 lesions, which are borderline for biopsy and follow-up. Material and methods: 175 consecutive women with 193 ultrasound-visible breast lesions were classified on Conventional B-mode Ultrasonography (CUS) according to BI-RADS scoring system. Quantitative and semiquantitative values from ultrasound elastography in the form of strain Elastography Ratio (SER), shear Wave Elastography (SWE) and Shear Wave Elastography Ratio (SWER) were obtained. The lesions categorized as BI-RADS 4a and BI-RADS 3 on ultrasound were subsequently re-categorized according to elastography values. Results: Except for the 13 BI-RADS 2 lesions, the remaining 180 lesions were biopsied. Pathology showed 83 lesions to be benign and 97 to be malignant. The sensitivity and specificity of the CUS was 96.9% and 75.0%, respectively with an accuracy of 86.0%. Cut-off points calculated based on ROC curves were 56.8 kPa for SWE, 3.53 for SWER and 3.81 for SER. When we downgraded BI-RADS 4a lesions based on elastography results, the specificity (CUS+SER 96.9%, CUS+SWE 91.7%, and CUS+SWER 90.6%) and the accuracy (CUS+SER 95.3%, CUS+SWE 92.7%, and CUS+SWER 92.2%) are better than CUS. When we upgraded BI-RADS 3 lesions based on elastography results, the sensitivity of combined sets of SWE (99, 0%) and SWER (100,0%) are better than CUS. Conclusion: The rate of false negative biopsies can be decreases with combined use of elastography and ultrasonography.Publication Metadata only A Case Series of Malign Hyperechoic Breast Lesions(2020-06-01T00:00:00Z) Toprak, Hüseyin; YILMAZ, TEMEL FATİH; SARI, LÜTFULLAH; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMAPublication Metadata only Diagnostic role of gray-scale and shear-wave elastography in pediatric patients with undescended testes: a prospective controlled study(2024-01-01) Yurtsever İ.; Yıldız Ş.; Amirjanov S.; Yılmaz Yozgat C.; Balsak S.; Peker A. A.; Atasoy B.; Erol A. B.; Toluk Ö.; Aydoğdu İ.; YURTSEVER, İSMAİL; YILDIZ, ŞEYMA; PEKER, ABDUSSELİM ADİL; ATASOY, BAHAR; TOLUK, ÖZLEM