Person: RAFIQI, ABDUL MATTEEN
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Publication Metadata only Hox gene function in the development of ant(2022-10-18) Çolak B.; Rafıqı A. M.; AL, BİRGÜL ÇOLAK; RAFIQI, ABDUL MATTEENPublication Metadata only Hox gene function in the evolution of body plan in Camponotus floridanus(2022-06-01) Çolak B.; Rafıqı A. M.; AL, BİRGÜL ÇOLAK; RAFIQI, ABDUL MATTEENPublication Metadata only Analysis of Dorsoventral Patterning of Camponotus floridanus(2022-05-31) Milat N. S.; Rafıqı A. M.; MİLAT, NİHAN SULTAN; RAFIQI, ABDUL MATTEENHighly conserved gene regulatory networks are responsible for pattern formation in development. In case of insects that host cellular endosymbionts, challenges are faced for understanding pattern formation because of the interactions between the endosymbiont and intercellular signals of the host developmental gene regulatory network. Studying how these networks are operated in the presence of endosymbionts is critical for understanding of the process of endosymbiosis at the organismal level as well as the evolution of developmental systems.We characterized Dorsal-Ventral (DV) patterning system of the ant, Camponotus floridanus. Since DV patterning depends heavily on Bone Morphogenetic Protein Signaling in many insects, we used molecular techniques such as gene cloning, in situ hybridization, and RNA interference to examine the expression and function of developmental genes that are particularly involved in Bone Morphogenetic Protein Signaling.Here we show the expression and function of core BMP signaling components for DV patterning of ant C. floridanus.Publication Metadata only Characterizing BMP Signaling in Early Development of an Insect that Houses Cellular Endosymbionts(2022-10-17) Rafıqı A. M.; Milat N. S.; RAFIQI, ABDUL MATTEEN; MİLAT, NİHAN SULTANPublication Metadata only Gut bacteria after recovery from COVID-19: a pilot study(2022-01-01) Polo P. G.; AL B. Ç.; ŞENTÜRK H.; RAFIQI A. M.; AL, BİRGÜL ÇOLAK; ŞENTÜRK, HAKAN; RAFIQI, ABDUL MATTEENOBJECTIVE: COVID-19 has been a major infectious disease lately in hu-mans. 10% of people experience persistent symptoms twelve weeks after having COVID-19. The gut microbiota is essential for host immunity. Thus, gut microbiota composition may contribute to the recovery of COVID-19 patients. The impact of COVID-19 on the gut microbiota of patients during recovery is less explored. We investigated the potential alterations of bacterial gut microbiota of immediately recovered COVID-19 patients, and six months after their recovery. MATERIALS AND METHODS: Stool samples were collected from 8 patients with COVID-19 immediately after their recovery, and six months after SARS-CoV-2 clearance, as well as from 8 healthy donors as a control group. 16S rRNA gene sequencing was performed to analyze the correlation between disease recovery and microbiota using the immediately recovered and control group. Specific primers were designed for the most significantly altered bacteria and used to analyze the changes in intestinal mi-crobiota composition of patients using qPCR. qPCR comparisons were performed on three groups: newly recovered from COVID-19, after six months of COVID-19 recovery, and healthy controls.RESULTS: Compared with the healthy con-trol group, patients who immediately recovered from COVID-19 had significantly less presence of 15 bacterial groups. The immediately recovered patients had a very significantly higher relative abundance of the opportunistic pathogen Mycolicibacterium. No differences were found between the immediately recovered patients, and after six months of recovery using the qP-CR analyses.CONCLUSIONS: Our results contribute novel insights regarding the alteration of human gut microbiota and the emergence of opportunistic pathogens in recovered patients of COVID-19. Further studies with a larger experimental size are needed to reveal balance or dysbiosis in patients after COVID-19 recovery.Publication Metadata only Gene Regulatory Networks Altered by Endosymbiosis(2023-07-18) Milat N. S.; Rafıqı A. M.; MİLAT, NİHAN SULTAN; RAFIQI, ABDUL MATTEEN