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Now showing 1 - 10 of 22
  • Publication
    Hox gene function in the development of ant
    (2022-10-18) Çolak B.; Rafıqı A. M.; AL, BİRGÜL ÇOLAK; RAFIQI, ABDUL MATTEEN
  • Publication
    Eco-Evo-Devo: The Time Has Come
    (2014-01-01T00:00:00Z) Abouheif, Ehab; Fave, Marie-Julie; Ibarraran-Viniegra, Ana Sofia; Lesoway, Maryna P.; Rafiqi, ABDUL MATTEEN; Rajakumar, Rajendhran; RAFIQI, ABDUL MATTEEN
    The major goal of ecological evolutionary developmental biology, also known as -eco-evo-devo,- is to uncover the rules that underlie the interactions between an organism-s environment, genes, and development and to incorporate these rules into evolutionary theory. In this chapter, we discuss some key and emerging concepts within eco-evo-devo. These concepts show that the environment is a source and inducer of genotypic and phenotypic variation at multiple levels of biological organization, while development acts as a regulator that can mask, release, or create new combinations of variation. Natural selection can subsequently fix this variation, giving rise to novel phenotypes. Combining the approaches of eco-evo-devo and ecological genomics will mutually enrich these fields in a way that will not only enhance our understanding of evolution, but also of the genetic mechanisms underlying the responses of organisms to their natural environments.
  • Publication
    Megaselia abdita: preparing embryos for injection.
    (2011-04-01T00:00:00Z) Rafiqi, ABDUL MATTEEN; Lemke, Steffen; Schmidt-Ott, Urs; RAFIQI, ABDUL MATTEEN
  • Publication
    Characterizing BMP Signaling in Early Development of an Insect that Houses Cellular Endosymbionts
    (2022-10-17) Rafıqı A. M.; Milat N. S.; RAFIQI, ABDUL MATTEEN; MİLAT, NİHAN SULTAN
  • Publication
    Taxonomic classification analysis of human gut microbiota using Kraken 2
  • Publication
    Investigation of the effect of different chelation solutions on penetration of resin‐based and bioceramic sealers with a novel method
    (2021-01-01T00:00:00Z) Alim, Betül Aycan; Şentürk , Hilal; Kotan, Gözde; Güneşer, Mehmet Burak; Dinçer, Asiye Nur; Rafıqı, Abdul Matteen; UYSAL, BETÜL AYCAN; KOTAN, GÖZDE; GÜNEŞER, MEHMET BURAK; DİNÇER, ASİYE NUR; RAFIQI, ABDUL MATTEEN
  • Publication
    Analysis of Dorsoventral Patterning of Camponotus floridanus
    (2022-05-31) Milat N. S.; Rafıqı A. M.; MİLAT, NİHAN SULTAN; RAFIQI, ABDUL MATTEEN
    Highly conserved gene regulatory networks are responsible for pattern formation in development. In case of insects that host cellular endosymbionts, challenges are faced for understanding pattern formation because of the interactions between the endosymbiont and intercellular signals of the host developmental gene regulatory network. Studying how these networks are operated in the presence of endosymbionts is critical for understanding of the process of endosymbiosis at the organismal level as well as the evolution of developmental systems.We characterized Dorsal-Ventral (DV) patterning system of the ant, Camponotus floridanus. Since DV patterning depends heavily on Bone Morphogenetic Protein Signaling in many insects, we used molecular techniques such as gene cloning, in situ hybridization, and RNA interference to examine the expression and function of developmental genes that are particularly involved in Bone Morphogenetic Protein Signaling.Here we show the expression and function of core BMP signaling components for DV patterning of ant C. floridanus.
  • Publication
    Megaselia abdita: fixing and devitellinizing embryos.
    (2011-04-01T00:00:00Z) Rafiqi, ABDUL MATTEEN; Lemke, Steffen; Schmidt-Ott, Urs; RAFIQI, ABDUL MATTEEN
  • Publication
    Origin and elaboration of a major evolutionary transition in individuality
    (2020-09-01T00:00:00Z) Rafiqi, Ab. Matteen; Rajakumar, Arjuna; Abouheif, Ehab; RAFIQI, ABDUL MATTEEN
    Obligate endosymbiosis, in which distantly related species integrate to form a single replicating individual, represents a major evolutionary transition in individuality(1-3). Although such transitions are thought to increase biological complexity(1,2,4-6), the evolutionary and developmental steps that lead to integration remain poorly understood. Here we show that obligate endosymbiosis between the bacteriaBlochmanniaand the hyperdiverse ant tribe Camponotini(7-11)originated and also elaborated through radical alterations in embryonic development, as compared to other insects. The Hox genesAbdominal A(abdA) andUltrabithorax(Ubx)-which, in arthropods, normally function to differentiate abdominal and thoracic segments after they form-were rewired to also regulate germline genes early in development. Consequently, the mRNAs and proteins of these Hox genes are expressed maternally and colocalize at a subcellular level with those of germline genes in the germplasm and three novel locations in the freshly laid egg.Blochmanniabacteria then selectively regulate these mRNAs and proteins to make each of these four locations functionally distinct, creating a system of coordinates in the embryo in which each location performs a different function to integrateBlochmanniainto the Camponotini. Finally, we show that the capacity to localize mRNAs and proteins to new locations in the embryo evolved before obligate endosymbiosis and was subsequently co-opted byBlochmanniaand Camponotini. This pre-existing molecular capacity converged with a pre-existing ecological mutualism(12,13)to facilitate both the horizontal transfer(10)and developmental integration ofBlochmanniainto Camponotini. Therefore, the convergence of pre-existing molecular capacities and ecological interactions-as well as the rewiring of highly conserved gene networks-may be a general feature that facilitates the origin and elaboration of major transitions in individuality.
  • Publication
    Megaselia abdita: culturing and egg collection.
    (2011-04-01T00:00:00Z) Rafiqi, ABDUL MATTEEN; Lemke, Steffen; Schmidt-Ott, Urs; RAFIQI, ABDUL MATTEEN