Person: KAHRAMAN AY, NURAY
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Publication Metadata only Endovascular therapy of acute ischaemic stroke by interventional cardiologists: single-centre experience from Turkey(2014-11-01) GOKTEKIN, Omer; TASAL, Abdurrahman; UYAREL, Huseyin; VATANKULU, Mehmet Akif; SONMEZ, Osman; AY, Nuray; KUL, Seref; YAMAC, Hatice; ALTINTAS, Ozge; KARADELI, Hasan; Kolukisa, MEHMET; Aralasmak, AYŞE; Asil, TALİP; KAHRAMAN AY, NURAY; KOLUKISA, MEHMET; ARALAŞMAK, AYŞE; ASİL, TALIPAims: We report our single-centre experience with the Solitaire AB self-expanding retrievable stent system in patients with acute ischaemic stroke.Publication Open Access Effects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats(2013-01-01) Ay, YASİN; Kara, Ibrahim; Aydin, CEMALETTİN; TEKER, Melike Elif; Senol, Serkan; Inan, BEKİR; BASEL, Halil; Uysal, Omer; Zeybek, RAHMİ; AY, YASİN; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAY; İNAN, BEKİR; UYSAL, ÖMER; ZEYBEK, RAHMİThis study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion damage in rats with myocardial ischemia/reperfusion. 38 male Wistar Albino rats used in this study were divided into 5 groups. The control group (Group 1) (n=6), ischemia/reperfusion (IR) group (Group 2) (n=8), cardiac ischemic preconditioning (CIP) group (Group 3) (n=8), iloprost (ILO) group (Group 4) (n=8), and cardiac ischemic preconditioning + iloprost (CIP+ILO) group (Group 5) (n=8). Pre-ischemia, 15 minutes post-ischemia, 45 minutes post-reperfusion, mean blood pressure (MBP), and heart rates (HR) were recorded. The rate-pressure product (RPP) was calculated. Post-reperfusion plasma creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin (cTn) vlaues, and infarct size/area at risk (IS/AAR) were calculated from myocardial tissue samples. Arrhythmia and ST segment elevations were evaluated during the ischemia and reperfusion stages. Although the MBP, HR, RPP values, biochemical parameters of CK-MB and LDH levels, IS/AAR rates, ST segment elevation values were found to be similar in CIP and CIP+ILO groups and the IR and ILO groups (p>0.05), CIP-containing group values had a positively meaningful difference (p<0.05) compared with the IR and ILO group. While mild-moderate findings of damage were observed in Group 3 and Group 5, severely findings of damage were releaved in Group 2 and Group 4. The arrhythmia score of the ILO group was meaningfully lower (F: 41.4, p<0.001) than the IR group. We can conclude that the effects of myocardial reperfusion damage can be reduced by cardiac ischemic preconditioning, intravenous iloprost reduced the incidence of ventricular arrhythmia associated with reperfusion, and its use with CIP caused no additional changes.Publication Open Access A Case of Spontaneous Multivessel Coronary Artery Spasm That Underwent Stent Implantation Accompanying ST Segment Elevation on Inferior Electrocardiographic Leads(2016-01-01T00:00:00Z) KAHRAMAN AY, Nuray; Nasifov, Muharrem; Goktekin, Omer; KAHRAMAN AY, NURAYCoronary artery spasm is usually defined as a focal constriction of a coronary artery segment, which is reversible, and causes myocardial ischaemia by restricting coronary blood flow. A coronary spasm may rarely compromise all three epicardial arteries simultaneously. We present a case of severe coronary spasm afflicting all coronary arteries accompanying an ST segment elevation in leads D2-D3 and aVF.Publication Metadata only The Effects of Levosimendan Exposure on Oxidant/Antioxidant Status and Trace Element Levels in the Pulmonary Artery of Rats(2013-06-01T00:00:00Z) AY, YASİN; AYDIN, CEMALETTİN; Basel, Halil; Bektaş, Hava; Bulut, Gulay; İNAN, BEKİR; Ay, NURAY; Demir, Ismail; AY, YASİN; AYDIN, CEMALETTİN; İNAN, BEKİR; KAHRAMAN AY, NURAYWe investigated both the effect of levosimendan and the role of oxidant/antioxidant status and trace element levels in the pulmonary artery of rats. Fourteen male Wistar albino rats were randomly divided into two groups of seven animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 mu g/kg) diluted in 10 ml 0.9 % NaCl was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their pulmonary arteries were harvested to determine changes in tissue oxidant/antioxidant status and trace element levels. The animals in both groups were killed 72 h after the levosimendan exposure treatment, and pulmonary arteries were harvested to determine levels of the lipid peroxidation product MDA and the antioxidant GSH as well as the decreased activity of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found that MDA levels increased in pulmonary artery tissues of rats after levosimendan administration. The GSH level decreased in the pulmonary artery of rats after levosimendan treatment. Co, Mn, Fe, Cd and Pb levels were significantly higher (P < 0.001) and Mg, Zn and Cu levels significantly lower (P < 0.001) in the levosimendan group compared to the control group. These results suggest that levosimendan treatment caused an increase in free radical production and a decrease in antioxidant enzyme activity in the pulmonary artery of levosimendan-treated rats. It also caused a decrease or increase in the levels of many minerals in the pulmonary artery, which is an undesirable condition for normal pharmacological function.Publication Open Access QT interval changes in term pregnant women living at moderately high altitude(2016-09-01) BATMAZ, G.; AKSOY, A.; Aydin, SERDAR; Dane, B.; AYDIN, SERDAR; KAHRAMAN AY, NURAYObjective: This study aimed to compare the QT interval changes in women with term pregnancy living at moderately high altitude (1890 m in Erzurum, Turkey) with those of women living at sea level (31 m in İstanbul, Turkey). Materials and Methods: One‑hundred ten women (n = 55, for each group) with full‑term and single child pregnancies. Two different locations in that state were selected: İstanbul, Turkey, which is at 31 m above sea level (Group 1) and Erzurum, Turkey, at 1890 m above sea level (Group 2). Physicians from the two locations participated in the study. We estimated QTc, QTc Max, QTc Min, QT, and QTcd intervals. Results: Moderately high altitude group had significantly longer QT parameters (QTc, QTc Max, QTc Min, QT, and QTcd intervals) compared with sea level group (P < 0.01, for all). Conclusions: According to our results, QT interval changes occur in term pregnant women living moderately high altitude. These changes may be associated with pregnancy‑related cardiovascular complications in moderately high altitude.Publication Open Access New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.(2016-12-01) AKTHSR, Muhammad Salman; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; TANRIKULU, MEHMET AKİF; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAY; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAYBACKGROUND Current research investigating the role of THBS2 and LECT-2 in atherogenesis is very limited. Therefore, we designed this study to demonstrate the role of THBS-2 and LECT-2 in atherosclerosis at the tissue level in fresh specimens. MATERIAL AND METHODS A total of 32 patients who underwent coronary bypass surgery were enrolled. Aortic wall punch biopsies were obtained at the site of proximal aortosaphenous bypass graft anastomosis. A specimen of left internal mammarian artery (LiMA) was taken from the segment just proximal to its anastomosis. The aortic tissue is representive of the atherosclerotic tisue, and LiMA tissue is representative of the non-atherosclerotic area. The specimens were painted with CD68 for macrophage, and THBS-2 and LECT-2 antibodies for immunohistochemical staining. RESULTS Aortic THBS-2 levels were significantly lower, whereas aortic LECT-2 levels were significantly higher when compare to LiMA (14.4±9.9 (5-30) and 36.9±13.0 (5-60) p: 0.0001 and 20.3±15.0 (5-60) and 20.8±13,8 (10-30) p: 0.0001, respectively). CD68+ and monocyte level correlated significantly with AHA atherosclerosis grade (p=0.01, r=0.45 and p=0.001, r=0.56, Spearman's test). CD68+ level correlated significantly with LECT-2 levels in atherosclerotic aortic tissue (p=0.026, r=0.392, Spearman's test), whereas aortic TSBN-2 levels were not. CONCLUSIONS The present study has taken the first steps to highlight new markers in atherosclerosis by using immunohistochemical method. The study results suggest that the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis.Publication Open Access Atrial conduction abnormalities in patients with psoriasis vulgaris.(2015-01-01) TASAL, A; GUVENC, TS; KUL, S; BACAKSIZ, AHMET; ERDOGAN, EZGİ BAŞAK; SONMEZ, O; SEVGILI, E; Dizman, DİDEM; ONSUN, NAHİDE; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; KAHRAMAN AY, NURAYBackground: Psoriasis vulgaris is one of the most common chronic inflammatory skin disorders. Patients with psoriasis are at risk of developing atrial fibrillation (AF). The electromechanical delay (EMD) is the time interval from the onset of the P wave on surface electrocardiography (ECG) to the beginning of the A wave. Prolonged atrial EMD is an independent risk factor for the development of AF. Aim: This study investigated the intra- and interatrial EMD in patients with psoriasis. Methods: This study included 85 adults with psoriasis vulgaris (Group 1) and 46 age- and sex-matched healthy individuals (Group 2). ECGs were obtained from all subjects, and atrial EMD variables were calculated. Results are reported as means ± standard deviations and percentages. Continuous variables were analysed using Student’s t-test. A p-value < 0.05 was considered statistically significant. Results: Interatrial electromechanical delay (IA-EMD) and intra-left atrial electromechanical delay (ILA-EMD) were significantly longer in the psoriasis group compared with controls. A correlation analysis between psoriasis severity (PASI score) and the atrial conduction parameters revealed a significant positive correlation between PASI and IA-EMD (r = 0.261, p < 0.001). In addition, there was a positive correlation between high-sensitivity C-reactive protein (hsCRP) and IA-EMD (p = 0.022). Conclusions: The atrial conduction time was longer in patients with psoriasis vulgaris and it correlated with the severity of disease and hsCRP. Since the association between delayed conduction and AF is known, the measurement of intra-atrial conduction times could be a practical tool to estimate the AF risk in these patients.Publication Metadata only Rapidly growing fungus ball on prosthetic valve: Candida albicans endocarditis(2015-06-01T00:00:00Z) Sonmez, Fatma Cavide; Ay, NURAY; Sonmez, Osman; AY, YASİN; SÖNMEZ, FATMA CAVİDE; KAHRAMAN AY, NURAY; AY, YASİNPublication Open Access Comparison of the Health Related Quality of Life of Patients Following Mitral Valve Surgical Procedures in the 6-Months Follow-up: A Prospective Study(2013-04-01T00:00:00Z) AY, YASİN; KARA, İBRAHİM; AYDIN, CEMALETTİN; KAHRAMAN AY, Nuray; İNAN, BEKİR; Basel, Halil; ZEYBEK, RAHMİ; AY, YASİN; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAY; İNAN, BEKİR; ZEYBEK, RAHMİPurpose: The aim of the present study is to evaluate the health-related quality of life of the patients who underwent mitral valve repair (MvRp) and mitral valve replacement (MVR).