Person: İÇAĞASIOĞLU, DİLARA FÜSUN
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Publication Metadata only Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever(2014-01-01T00:00:00Z) Karadag-Oncel, Eda; EREL, Ozcan; ÖZSÜREKCİ, YASEMİN; CAGLAYIK, Dilek Yagci; KAYA, ALİ; Gozeol, Mustafa Gokhan; İÇAĞASIOĞLU, FÜSUN DİLARA; ENGİN, AYNUR; KORUKLUOGLU, Gulay; UYAR, Yavuz; Elaldi, Nazif; Ceyhan, Mehmet; İÇAĞASIOĞLU, DİLARA FÜSUNIn this study, we investigated the pro- and antioxidant status of patients with a pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age- and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically significant (P > 0.05). Mean TOS, OSI, and TTL values were significantly lower in CCHF patients than in healthy controls (P 0.05). Our results suggest that TTL may play a more important role in CCHF pathogenesis than the other parameters investigated. The mean TOS and OSI values were higher in the control group than in CCHF patients.Publication Metadata only Elevated chemokine levels during adult but not pediatric Crimean-Congo hemorrhagic fever(2015-05-01T00:00:00Z) Arasli, Mehmet; ÖZSÜREKCİ, YASEMİN; ELALDI, NAZİF; MCAULEY, Alexander J.; Oncel, Eda Karadag; Tekin, Ishak Ozel; GÖZEL, MUSTAFA GÖKHAN; KAYA, ALİ; İÇAĞASIOĞLU, FÜSUN DİLARA; CAGLAYIK, Dilek Yagci; KORUKLUOGLU, Gulay; Kokturk, Furuzan; Bakir, Mehmet; BENTE, Dennis A.; Ceyhan, Mehmet; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemoattractant mediators of the host immune system.Publication Metadata only Treatment failure of gentamicin in pediatric patients with oropharyngeal tularemia(2011-07-01T00:00:00Z) KAYA, ALİ; UYSAL, İSMAİL ÖNDER; GÜVEN, AHMET SAMİ; ENGİN, AYNUR; GÜLTÜRK, ABDULAZİZ; İÇAĞASIOĞLU, FÜSUN DİLARA; Cevit, Omer; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Tularemia is a zoonotic infection, and the causative agent is Francisella tularensis. A first-line therapy for treating tularemia is aminoglycosides (streptomycin or, more commonly, gentamicin), and treatment duration is typically 7 to 10 days, with longer courses for more severe cases.Publication Metadata only Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever(2014-01-01T00:00:00Z) GÜVEN, AHMET SAMİ; SANCAKDAR, ENVER; KAYA, ALİ; UYSAL, ELİF BİLGE; OFLAZ, MEHMET BURHAN; BOLAT, FATİH; KARAPINAR, HEKİM; KOÇ, ELİF; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUNPurpose: The aim of this study was to assess the role of ABO blood groups in predicting disease severity and bleeding potential in children with Crimean-Congo hemorrhagic fever (CCHF). Methods: One hundred fifty-one hospitalized patients with CCHF were enrolled in this retrospective study. The patients were divided according to O- and non-O-(A, B and AB) blood groups (n=91 and n=60, respectively). They were also classified into two groups (severe and non-severe) based on disease severity (n=29 and n=122, respectively). Demographic characteristics, clinical findings, and hematologic and biochemical parameters of all patients were recorded on admission and discharge. Results: Although, in all cases, compared to the non-O blood group, the ratio of the blood group O was considerably higher (60% vs. 40%) and similarly so in severe cases (58.6% vs. 41.4%), this difference was not statistically significant (p>0.05). The aPTT at discharge and fever duration of the O-blood group were significantly higher than those of the non-O-blood group (p=0.042, p=0.034, respectively). The factor VIII level of the O-blood group was significantly lower than that of the non-O-blood group (p=0.040). Although the ratios of bleeding and severity were higher in the O-blood group compared to the other group, statistical significance was not reached (p>0.05). Conclusions: Consideration of the ABO blood group is important during diagnostic follow-up to assess the severity of CCHF. In clinical practice, pediatric CCHF patients with the O blood group need to be followed closely for tendency to bleed.Publication Metadata only Can the Mild Clinical Course of Crimean-Congo Hemorrhagic Fever in Children Be Explained by Cytokine Responses?(2013-11-01T00:00:00Z) ÖZSÜREKCİ, YASEMİN; Arasli, Mehmet; Oncel, Eda Karadag; CAGLAYIK, Dilek Yagci; KAYA, ALİ; İÇAĞASIOĞLU, FÜSUN DİLARA; ENGİN, AYNUR; KORUKLUOGLU, Gulay; ELALDI, NAZİF; CEYHAN, MEHMET; İÇAĞASIOĞLU, DİLARA FÜSUNCytokines are possibly one of the factors responsible for death due to Crimean-Congo hemorrhagic fever (CCHF). This study aimed to determine the differences between the cytokine levels in children and adult patients with CCHF; the influence of cytokines; and the severity of the course of the disease, which seems to be milder in children. Thirty-four children and 36 adult patients diagnosed with CCHF between 2010 and 2011 were included in this study. Diagnosis was performed by serology or by the polymerase chain reaction for CCHF virus. Levels of IFN-, TNF-, IL-1, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12 p70, IL-13, IL-17A, and IL-22 were measured in all serum samples. Although the disease had a fatal course in three adult patients, there were no deaths in children. Statistically significant differences were not observed between the cytokine concentrations in the adults and children. No differences were detected between the serum cytokine levels in the children with moderate and those with a severe clinical course of the disease. In the adult patients with fatal outcome, significantly higher serum levels of IL-2, IL-5, IL-9, IL-12 p70, and IL-13 were detected as compared to the cytokine levels in patients who survived the infection. No differences were detected between the serum levels of IFN-, IL-1, IL-17A, IL-22, IL-10, IL-6, IL-4, and TNF- in the patients who died and those who survived. Thus, the milder clinical course in children with CCHF cannot be explained by the cytokine network alone. The incomplete maturation of the immune system and timing and scale of immune responses could change the outcome dramatically. J Med. Virol. 85:1955-1959, 2013. (c) 2013 Wiley Periodicals, Inc.Publication Metadata only Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases(2012-03-01T00:00:00Z) KAYA, ALİ; DEVECI, Koksal; UYSAL, İSMAİL ÖNDER; GÜVEN, AHMET SAMİ; DEMİR, MEVLÜT; UYSAL, ELİF BİLGE; GÜLTEKİN, ASIM; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUNKaya A, Deveci K, Uysal IO, Guven AS, Demir M, Uysal EB, Gultekin A, Icagasioglu FD. Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases. Mirk J Pediatr 2012; 54: 105-112.Publication Metadata only Cardiac findings in children with Crimean-Congo hemorrhagic fever(2011-08-01T00:00:00Z) GÜL, İBRAHİM; KAYA, ALİ; GÜVEN, AHMET SAMİ; KARAPINAR, HEKİM; KÜÇÜKDURMAZ, ZEKERİYA; YILMAZ, AHMET; İÇAĞASIOĞLU, FÜSUN DİLARA; Tandogan, Izzet; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Crimean-Congo hemorrhagic fever (CCHF) involves the multi-organ systems. The involvement of the heart in adult patients has been described previously. We investigated the electrocardiographic and echocardiographic findings of pediatric patients with CCHF.Publication Metadata only Crimean-Congo hemorrhagic fever disease due to tick bite with very long incubation periods(2011-07-01T00:00:00Z) KAYA, ALİ; ENGİN, AYNUR; GÜVEN, AHMET SAMİ; İÇAĞASIOĞLU, FÜSUN DİLARA; Cevit, Omer; ELALDI, NAZİF; GÜLTÜRK, ABDULAZİZ; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with a high mortality rate, and is one of the viral hemorrhagic fever syndromes. The average mortality rate of CCHF is 3-30%. Research indicates that the longest incubation period after a tick bite is 12 days in CCHF disease. However, in clinical practice, we encounter patients with CCHF as a result of tick bites with much longer incubation periods (max. 53 days) than those reported in the literature. We present herein CCHF cases presumably infected through tick bites and having incubation periods longer than the upper limit reported in the literature.Publication Metadata only Assessment of 17 Pediatric Cases With Colchicine Poisoning in a 2-Year Period(2016-03-01T00:00:00Z) Alaygut, Demet; Kilic, Suar Caki; KAYA, ALİ; OFLAZ, MEHMET BURHAN; BOLAT, FATİH; Cevit, Omer; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUNAim The aim of the study is to discuss clinical effects, treatments, and outcomes of pediatric colchicine poisoning.Publication Metadata only Resting Heart Rate in Children with Crimean-Congo Hemorrhagic Fever: A Tool to Identify Patients at Risk?(2014-01-01T00:00:00Z) OFLAZ, MEHMET BURHAN; BOLAT, FATİH; KAYA, ALİ; GÜVEN, AHMET SAMİ; KÜÇÜKDURMAZ, ZEKERİYA; KARAPINAR, HEKİM; GÜLSEVER, OSMAN; Dogan, Melih; Cevit, Omer; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUNObjective: We aimed to assess the association between resting heart rate (RHR) and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Methods: In all, 121 patients under 18 years of age with a laboratory-confirmed diagnosis of CCHF were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and nonsevere group). RHR was measured by electrocardiography (ECG) on admission. Maximum P-wave duration (Pmax), P-wave dispersion (Pd), QRS duration, corrected QT interval, and QT dispersion were also measured. Results: Mean age was 11.43.9 years and 84 patients were male. Twenty-six patients were classified as severe. Patients in this group had a higher RHR (103.6 +/- 10.4vs. 80.5 +/- 8.1, p=0.001) than those with nonsevere disease. There was no difference in Pmax, Pd, QRS duration, QTcmax, or QTc dispersion. The optimal cutoff value of RHR to predict disease severity was>96 beats per minute (bpm), with 70.6% sensitivity and 50.1% specificity. Bleeding, thrombocytopenia (80x10(9)/L), elevated aspartate transaminase (AST) (>208IU/L), elevated alanine transaminase (ALT) (>87IU/L), elevated lactate dehydrogenase (LDH) (>566IU/L), long activated partial thromboplastin time (aPTT) (>42s), and increased hospitalization days were more frequent in patients with RHR >96bpm. Multivariate logistic regression analysis revealed low platelet count (42s), high LDH (>566IU/L), and elevated RHR (>96bpm) as independent risk factors for severe disease. Conclusions: We conclude that elevated RHR was significantly associated with severe disease in children with CCHF, thus offering the potential to identify patients with increased risk.