Person: UÇKAYA, FATİH
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Publication Metadata only Chitosan and carboxymethyl cellulose based magnetic nanocomposites for application of peroxidase purification(2017-03-01) Kurt, BELMA; Uckaya, FATİH; Durmus, ZEHRA; ZENGİN KURT, BELMA; UÇKAYA, FATİHRecently, protein purification methods have a very wide area of research. Many of these methods are both expensive and multi-stage methods, that are needed in specific equipment. In this study, biopolymer coated magnetic nanoparticles, carboxymethyl cellulose (CMC) and chitosan (CH) coated Fe3O4 (magnetite) nanocomposites, are used in a new purification process. The structure of the synthesized magnetic nanocomposites were characterized by Fourier transform infrared (FTIR) spectrometry, X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), thermogravimetric (TGA) analysis and zeta potential for surface charge of magnetic nanocomposites. Molecular weight and purification degree of peroxidase were estimated with SDS-PAGE. Peroxidase enzyme was purified a yield of 82.55% with carboxymethyl cellulose and 76.72% with chitosan using this method. (C) 2016 Elsevier B.V. All rights reserved.Publication Metadata only Diterpens and other constituens from Ajuga spp. with cytotoxic activity(2015-08-01) Yapar, Gönül; Uckaya, FATİH; Topcu, GÜLAÇTI; UÇKAYA, FATİH; TOPÇU, GÜLAÇTIPublication Metadata only Treatment of Ulcerative Colitis Disease with Rosmarinus officinalis(2017-01-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; Bayındır, Nihan; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIPublication Metadata only Evaluation of the efficiency and safety in cosmetic products(2016-02-01T00:00:00Z) Uckaya, Meryem; UÇKAYA, FATİH; DEMİR, NAZAN; DEMİR, YAŞAR; UÇKAYA, FATİHChemicals used in cosmetics have to interact with enzymes for beneficial or destroy purpose after they enter in our body. Active sections of enzymes that catalyze reactions have three dimensions and they are active optically. When these limitations of catalytic sections are considered, it may be considered that defining geometric specifications of chemical materials and functional groups they contain may contribute on safety evaluations of cosmetic products.Publication Metadata only Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats(2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.Publication Metadata only Therapeutic effects of Licorice (Glycyrrhiza glabra) on colitis through its antioxidant properties and biochemical analyses(2015-08-01) Uckaya, FATİH; Bektay, Yunus; Yilmaz, ANIL; Bayindir, NİHAN; Selek, ŞAHBETTİN; Topcu, GÜLAÇTI; Esrefoglu, MUKADDES; UÇKAYA, FATİH; BEKTAY, MUHAMMED YUNUS; YILMAZ, ANIL; BAYINDIR, NİHAN; SELEK, ŞAHABETTİN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Metadata only Mis Zambağının (Lilium candidum) Biyokimyasal Aktivitelerinin ve Endüstriyel Amaçlı Kullanılabilirliğinin Araştırılması(2017-03-01T00:00:00Z) DEMİR, NAZAN; DEMİR, YAŞAR; UÇKAYA, FATİH; IŞIK, CEYHUN; UÇKAYA, FATİH