Person: UÇKAYA, FATİH
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Publication Metadata only Investigation of Anti-Oxidant and Toxicological Effects Of Methanolic Extract of Rosmarinus officinalis(2015-10-17) BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Metadata only Treatment of Ulcerative Colitis Disease with Rosmarinus officinalis(2017-01-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; Bayındır, Nihan; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIPublication Open Access Antioxidant and toxicological in-vivo and in-vitro examination of licorice extract(2016-09-01) Bektay, MUHAMMED YUNUS; Uckaya, FATİH; Guler, E. M.; Bayindir, NİHAN; Kocyigit, ABDÜRRAHİM; Esrefoglu, MUKADDES; Topcu, GÜLAÇTI; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; GÜLER, ERAY METİN; BAYINDIR, NİHAN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIPublication Metadata only Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats(2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.Publication Metadata only Therapeutic effects of Licorice (Glycyrrhiza glabra) on colitis through its antioxidant properties and biochemical analyses(2015-08-01) Uckaya, FATİH; Bektay, Yunus; Yilmaz, ANIL; Bayindir, NİHAN; Selek, ŞAHBETTİN; Topcu, GÜLAÇTI; Esrefoglu, MUKADDES; UÇKAYA, FATİH; BEKTAY, MUHAMMED YUNUS; YILMAZ, ANIL; BAYINDIR, NİHAN; SELEK, ŞAHABETTİN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Metadata only Investigation of In-Vitro and In-Vivo Anti-Oxidant Effects of Matricaria chamomilla Extract on Rat Model of Ulcerative Colitis.(2015-08-31) Bektay, MUHAMMED YUNUS; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; Topçu, GÜLAÇTI; Üçkaya, FATİH; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHANPublication Metadata only Treatment of Ulcerative Colitis Disease with Rosmarinus officinalis(2017-04-29T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; Bayındır, Nihan; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI