Person: İZZETTİN, FIKRET VEHBI
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Publication Metadata only Evaluation of analgesic use behaviors of individuals for pain management: an observational study(2022-11-25) Köroğlu F.; Mercümek B.; Bektay M. Y.; İzzettin F. V.; MERCÜMEK, BERRE; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBIPublication Open Access Determination of Potential Drug-Drug Interactions Using Various Software Programs in a Community Pharmacy Setting(2019-03-01T00:00:00Z) SANCAR, MESUT; Kasik, Aksa; OKUYAN, BETÜL; Batuhan, Sevda; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIObjectives: The aim of the present study was to compare various software programs in detecting potential drug-drug interactions in a community pharmacy setting. Materials and methods: Details of prescriptions were collected from 50 community pharmacies located in İstanbul in March and April 2015 (two days per week). From each pharmacy, the first 20 prescriptions that included more than one drug were collected to evaluate potential drug-drug interactions. The following software programs were utilized to detect potential drug-drug interactions: micromedexsolutions.com, medscape.com, and drugs.com. The number of potential interactions detected by the software programs was determined. Results: At least one potential drug-drug interaction was detected in 39.2% of the 1000 prescriptions by one of the software programs. According to the rates of total drug-drug interactions gathered from various software programs, these programs gave the following results: medscape.com 33.3%, drugs.com 31.3%, and micromedexsolutions.com 21.2%. Conclusion: After comparing different software programs, the potential drug-drug interactions found by the programs proved to be different. Therefore, we recommend that pharmacists confirm with a different program before making a decision when they detect clinically significant potential drug-drug interactions.Publication Open Access Time to change to improve health: clinical pharmacy and pharmaceutical care education in Turkey(2020-05-01T00:00:00Z) Bektay, Muhammed Yunus; Sancar, Mesut; Al-Ezzı, Saad Ahmed Ali; BEKTAY, MUHAMMED YUNUS; AL-EZZI, SAAD AHMED ALİ; İZZETTİN, FIKRET VEHBIThe practice of clinical pharmacy had a positive impact on the profession by giving pharmacists more job opportunities. Moreover, the pharmacy began to gain the status it deserved, which was lost many years ago. In this paper, we aimed to give a brief explanation of the clinical pharmacy philosophy and definition of pharmaceutical care. What are the general and specific roles of clinical pharmacists in the modern world healthcare system? Also, how to implement clinical pharmacy in education to obtain competent pharmacists. We shared our observation and experience, specifically on the progress of implementation of clinical pharmacy education in Turkey. The stepwise method has been successfully followed in the implementation of clinical pharmacy education in Turkey. In the undergraduate program, the first step taken was the addition of clinical courses, such as the role of clinical pharmacy, patient education, etc. and practical hospital rounds (internal medicine, pediatrics, and surgery). The post-graduate program, such as master (MSc) and doctoral (Ph.D.) degrees, also offered to prepare clinically oriented pharmacy academicians. The continuous education programs were structured to implement clinical pharmacy idea for the pharmacists in practice. In conclusion, the stepwise approach significantly smoothed the transition from the product-oriented to the patient-oriented pharmacy education. Moreover, the adoption of the skills education system to educate pharmacists needs to review the policy regularly and gradually change it accordingly.Publication Metadata only Identification and evaluation of drug-related problems in the cardiology ward: an interventional study(2022-11-25) Sosyal D.; Bektay M. Y.; Açıkgöz N.; İzzettin F. V.; SOSYAL, DAMLA; BEKTAY, MUHAMMED YUNUS; AÇIKGÖZ, NUSRET; İZZETTİN, FIKRET VEHBIPublication Open Access Evaluation of satisfaction and internet self-efficacy of inquirers using an internet-based drug information centre(2019-02-01T00:00:00Z) Izzettin, FİKRET VEHBİ; YILMAZ, ZAHİT; OKUYAN, BETÜL; SANCAR, MESUT; İZZETTİN, FIKRET VEHBIObjectives: This study aimed to evaluate the satisfaction level of inquirers of an internet-based drug information centre along with the internet usage abilities and habits of individuals who had previously utilised services from an internet-based drug information centre in Turkey. Methods: The first 100 individuals who received medication consultancy from the webpage entitled “www.ilacpedia.com” and consented to participate in the study were included in this study. This website is an internet-based drug information centre. Participants' data were collected using a participant data form and the Internet Self-efficacy Scale. Results: The mean age of participants was 37.92 ± 12.32 years (71 female). It was found that 89% of the individuals who received pharmaceutical consultation from the internet-based drug information service believed that the information that they received was enough to solve their problem. The internet self-efficacy scale scores indicated the highest score on the decomposition subscale (20.94 ± 6.18) and the lowest on the communication subscale (9.77 ± 3.57). Conclusions: The present study revealed that the internet-based drug information service provided by clinical pharmacists contributed positively to users' satisfaction, thus indicating the importance of the involvement of clinical pharmacists in this process.Publication Metadata only Investigation of drug-related problems in hospitalized patients with respiratory diseases: a randomized controlled trial(2022-11-25) Bektay M. Y.; Sancar M.; Okyaltırık F.; Durdu B.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; OKYALTIRIK, FATMANUR; DURDU, BÜLENT; İZZETTİN, FIKRET VEHBIPublication Metadata only Determination of CYP2C19 Polymorphism, Side Effects, and Medication Adherence in Patients Who have Utilized Selective Serotonin Reuptake Inhibitors(2016-06-01T00:00:00Z) Deniz, Semanur; SANCAR, MESUT; OKUYAN, BETÜL; ATA, PINAR; Ozakpinar, Ozlem Bingol; TALAS, Anil; GUNES, Tufan; CALISKAN, Mecit; Izzettin, Fikret Vehbi; İZZETTİN, FIKRET VEHBIObjective: The aim of this study is to determine relationship of cytochrome P-450 2C19 (CYP2C19) enzymes polymorphism, side effects, and medication adherence in patients who have been diagnosed with major depression and have utilized selective serotonin reuptake inhibitors.Publication Metadata only Assessment of the Attitude of Community Pharmacists and Pharmacy Technicians towards Diarrhea: A Simulated Patient Study in Turkey(2015-08-01T00:00:00Z) SANCAR, MESUT; Tezcan, Elif; OKUYAN, BETÜL; Izzettin, Fikret Vehbi; İZZETTİN, FIKRET VEHBIPurpose: To evaluate community pharmacists- and pharmacy technicians- counselling practices regarding diarrhea in Istanbul-Turkey using a simulated patient study.Publication Metadata only Therapeutic Drug Monitoring in Pediatric Patients Treated with Anti-Tuberculosis Medications by High Performance Liquid Chromatography(2022-01-01) OKUYAN B.; TOK F.; KARAKUŞ S.; Dalgiç N.; ÇAKIR E.; Midyat L.; Koçyiğit-Kaymakçioğlu B.; Berk U. E.; İZZETTİN F. V.; Rollas S.; et al.; ÇAKIR, ERKAN; İZZETTİN, FIKRET VEHBI© 2022 Marmara University Press.The aim of this study is to perform therapeutic drug monitoring for isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA) in pediatric tuberculosis patients. The study was carried out in 3 different training-research hospitals in Istanbul, Türkiye between 2011 and 2012. The pediatric patients (aged ≤14 years) who initiated the standard primary anti-tuberculosis therapy were included in this study. The serum samples were collected 3 hours after the first medication doses were given on the 5th day of treatment. Chromatographic experiments were performed on an Agilent 1100 High-Performance Liquid Chromatography (HPLC) system, and the separation was carried out on a Nova-Pak C18 (3.9x150 mm, 5 μm, Merck) analytical column. In this HPLC method, the gradient elusion delivered 3% to 40% (v/v) acetonitrile in phosphate buffer was used, and diode array detector. Twenty-three children (60.9% male) patients were included with a mean age of 111.70 ± 59.94 months. Plasma levels were measured sub-therapeutically for INH in 14, RIF in 10, and PZA in 5 patients, according to the normal range of adult patients. Maximum plasma concentrations after three hours were found between 0.53-14.02 mg/L for INH, 11.17-60.39 mg/L for PZA, 2.15-16.75 mg/L for RIF. In conclusion, this method has been successfully applied to simultaneously determine RIF, INH, and PZA plasma levels in pediatric tuberculosis patients. RIF and INH plasma levels were found to be lower in pediatric patients with tuberculosis compared to target range of adult patients.Publication Metadata only Identification of potentially inappropriate medications in elderly according to the FORTA and EU (7)-PIM lists: an observational study(2022-11-25) Özmen Ö.; Bektay M. Y.; Karatoprak C.; İzzettin F. V.; ÖZMEN, ÖZGE; BEKTAY, MUHAMMED YUNUS; KARATOPRAK, CUMALİ; İZZETTİN, FIKRET VEHBI