Person: ŞEKERCİ, ABDÜSSELAM
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Publication Metadata only Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women(2022-01-01T00:00:00Z) ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; Güler, Eray Metin; Gülen, Bedia; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFABackground: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.Publication Metadata only Diyabet ve Prediyabet Hastalarındaki Kognitif Bozulmanın Hipertrigliseridemi İle İlişkisi(2023-06-14) Şekerci A.; Sümbül Şekerci B.; ŞEKERCİ, ABDÜSSELAM; SÜMBÜL ŞEKERCİ, BETÜLPublication Metadata only COVID-19 and COMORBIDITIES(2020-08-01T00:00:00Z) Şekerci, Abdüsselam; ŞEKERCİ, ABDÜSSELAMA novel coronavirus was identified in Wuhan in December 2019 and it rapidly spread throughout China, followed by in other countries. The aim of this study is to investigate the effects of comorbidities on patients with COVID-19 and to give information about their management. The electronic databases PubMed and Google Scholar have been used to assess comorbidities and clinical characteristics of COVID-19. Severe disease predominantly occurs in adults with underlying medical comorbidities or advanced age. Comorbidities and other conditions that associated with morbidity and mortality include hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease, cancer (particularly metastatic disease, lung cancer, and hematologic malignancies) and chronic kidney disease. As the number of comorbidity increases, patients- clinic progresses more severely. A comprehensive assessment and good management of comorbidities can help patients with COVID-19 achieve a better outcome.Publication Metadata only Etanercept Kullanımı Sırasında Inh Profilaksisine Rağmen Gelişen Tüberküloz Peritonit(2022-01-04) Uslu Ersöz A. B.; Akkoyunlu Y.; Karakuş H. D.; Şekerci A.; Aslan T.; AKKOYUNLU, YASEMİN; KARAKUŞ, HATİCE DİLARA; ŞEKERCİ, ABDÜSSELAM; ASLAN, TURANPublication Open Access An evaluation of people's knowledge of adult vaccination information level and attitudes during the pandemic Era(2021-01-01T00:00:00Z) Kiskac, Nese; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; ZORLU, MEHMET; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; ZORLU, MEHMETOBJECTIVE: This research was carried out to evaluate people-s knowledge of adult vaccination and their attitude and to observe the effect of the pandemic era on this situation. METHODS: A total of 1,425 people (18-80 years old) were included in this study. The types of questions like the province where they live, age, gender, occupation, education status, and the presence of chronic diseases, as well as knowing which vaccines are used in adult vaccination, which of these vaccines they had in the last 10 years, which ones they plan to have this year, and whether COVID-19 pandemic changed their perspective on adult vaccinations or not were asked to people. RESULTS: In the last 10 years, while participants stated that they had the highest rate of tetanus vaccine with 29.8%, hepatitis B vaccine with 23.1%, influenza vaccine with 22.7%, human papillomavirus vaccine with 1.3%, and zoster vaccine with 0.3% were the lowest levels of vaccines. CONCLUSIONS: As a result, it seems that we are far from the goals set by the health authorities for adult vaccination. We observed that the COVID-19 pandemic raised awareness toward pneumococcus and influenza vaccines and interest toward adult vaccinations and at the same time changed the thoughts against adult vaccinations.Publication Open Access Markers predicting critical illness and mortality in COVID-19 patients: A multi-centre retrospective study(2021-01-01T00:00:00Z) Büyükaydın, Banu; Karaaslan, Tahsin; Karatoprak, Cumali; Karaaslan, Esra; Sasak Kuzgun, Gulsah; Gündüz, Mehmet; Şekerci, Abdusselam; Alişir Ecder, Sabahat; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; BÜYÜKAYDIN, BANUAim: In this study, we aimed to investigate early predictors of critical illness and mortality in patients with coronavirus disease 2019 (COVID-19) based onclinical, biochemical, radiological, and epidemiological findings.Materials and Methods: This multi-center, retrospective study was conducted in three centers and included a total of 206 confirmed COVID-19 cases usingreverse transcription-polymerase chain reaction (RT-PCR). Data of survivors and non-survivors were compared, and predictors of mortality were examined.Results: Among the patients, 103 (50%) were males with a mean age of 52.8±16.7 years; 88.3% of the patients were discharged in a healthy condition, while11.7% died. The mean age was significantly higher in non-survivors. Dyspnea occurred in 32.5% of patients, and a significant correlation was found betweendyspnea and mortality (p<0.001). Thoracic computed tomography (CT) findings were positive in 88.8% of patients. The most frequent imaging findings wereground-glass opacities in 86.4% and consolidation in 33% of patients. The mortality rate was significantly higher in patients with comorbidities (p<0.001).There was also a significant correlation between lymphocytopenia and mortality (p<0.001). A positive correlation was found between mortality risk andplatelet-to-lymphocyte, neutrophil-to-lymphocyte, and red cell distribution width indices. The mortality risk was significantly higher in patients with acutekidney injury (10.7%) (p<0.001).Discussion: These results suggest that advanced age, coexisting diabetes, hypertension, heart failure, chronic kidney disease, or acute kidney injury are associatedwith an increased mortality risk. The presence of dyspnoea or consolidation on thoracic CT can predict an increased mortality risk in COVID-19 patients.Publication Metadata only COVID-19 PANDEMİSİNDE PALYATİF BAKIM(Üniversite Yayınları, 2021-10-01) Akçakaya A.; Şekerci A.; AKÇAKAYA, ADEM; ŞEKERCİ, ABDÜSSELAMPublication Metadata only B12 Eksikliği; DNA Hasarı, Enflamasyon ve Oksidatif Stresi İndükler mi?(2022-05-29) Dumlu F. S.; Şekerci A.; Aktaş S.; Güler E. M.; ŞEKERCİ, ABDÜSSELAMPublication Metadata only Diyabet Hastalarında Gözardı Edilen Bir Komplikasyon: Kognitif Bozulma.(2022-12-23) Şekerci A.; Sümbül Şekerci B.; Selvitop R.; Yüksel Salduz Z. İ.; ŞEKERCİ, ABDÜSSELAM; SÜMBÜL ŞEKERCİ, BETÜL; YÜKSEL SALDUZ, ZEYNEB İREMPublication Metadata only Hazır Karışım İnsülinler(Nobel Yayınevi, 2021-09-01) Şekerci A.; ŞEKERCİ, ABDÜSSELAM