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ŞEKERCİ, ABDÜSSELAM

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ABDÜSSELAM
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ŞEKERCİ
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    Association between the peripheral blood parameters and Alzheimer’s disease in patients with type-2 diabetes mellitus: a case–control study
    (2022-10-01T00:00:00Z) Sümbül Şekerci, Betül; Şekerci, Abdüsselam; Gelişin, Özlem; SÜMBÜL ŞEKERCİ, BETÜL; ŞEKERCİ, ABDÜSSELAM
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    Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women
    (2022-01-01T00:00:00Z) ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; Güler, Eray Metin; Gülen, Bedia; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA
    Background: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.
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    Clinicopathological features of gastroenteropancreatic neuroendocrine neoplasms: a retrospective single-center experience
    (2021-03-01T00:00:00Z) ŞEKERCİ, ABDÜSSELAM; TÜRK, HACI MEHMET; DEMİR, Tarık; ŞEKER, Mesut; AKÇAKAYA, Adem; ARICI, Dilek Sema; ŞEKERCİ, ABDÜSSELAM; TÜRK, HACI MEHMET; DEMİR, TARıK; ŞEKER, MESUT; AKÇAKAYA, ADEM; ARICI, DILEK SEMA
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    PublicationOpen Access
    Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?
    (2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN
    Objective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.
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    COVID-19 and COMORBIDITIES
    (2020-08-01T00:00:00Z) Şekerci, Abdüsselam; ŞEKERCİ, ABDÜSSELAM
    A novel coronavirus was identified in Wuhan in December 2019 and it rapidly spread throughout China, followed by in other countries. The aim of this study is to investigate the effects of comorbidities on patients with COVID-19 and to give information about their management. The electronic databases PubMed and Google Scholar have been used to assess comorbidities and clinical characteristics of COVID-19. Severe disease predominantly occurs in adults with underlying medical comorbidities or advanced age. Comorbidities and other conditions that associated with morbidity and mortality include hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease, cancer (particularly metastatic disease, lung cancer, and hematologic malignancies) and chronic kidney disease. As the number of comorbidity increases, patients- clinic progresses more severely. A comprehensive assessment and good management of comorbidities can help patients with COVID-19 achieve a better outcome.
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    Clinicopathological Features of Gastroenteropancreatic Neuroendocrine Neoplasms.
    (2020-08-01T00:00:00Z) Sekerci, A; Turk, HM; Demir, T; Seker, M; Akcakaya, Adem; Arici, DS; ŞEKERCİ, ABDÜSSELAM; TÜRK, HACI MEHMET; AKÇAKAYA, ADEM
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    PublicationOpen Access
    An evaluation of the relationship between vitamin D level and CTRP-9, tumor necrosis factor-alpha, thiol-disulfide hemostasis in women
    (2021-01-01T00:00:00Z) KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; Guler, Eray Metin; TUNÇ, MUHAMMED; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; ÇAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; ZORLU, MEHMET
    Objective: Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFα, and thiol-disulfide hemostasis. We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFα, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency. Methods: In our study, 78 female volunteers older than 18 years were included. Volunteers were divided into three groups according to the reference values of vitamin D levels. Biochemical parameters, CTRP-9, TNFα, and thiol/disulfide hemostasis tests taken from all volunteers were studied. Results: In this study, there was a significant difference in CTRP-9, TNFα, total thiol (TT), native thiol (NT), DIS (disulfide), TT/DIS, and NT/DIS levels in vitamin D groups (p<0.05). There was a significant negative correlation between vitamin D and TNFα and DIS, while a significant positive correlation was found with CTRP-9, TT, NT, TT/DIS, and NT/DIS (p<0.05). Conclusions: It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFα level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress. We considered that these changes may play mediator roles for many chronic diseases and metabolic disorders that are increasing in frequency due to vitamin D deficiency.
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    PublicationOpen Access
    An evaluation of people's knowledge of adult vaccination information level and attitudes during the pandemic Era
    (2021-01-01T00:00:00Z) Kiskac, Nese; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; ZORLU, MEHMET; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; ZORLU, MEHMET
    OBJECTIVE: This research was carried out to evaluate people-s knowledge of adult vaccination and their attitude and to observe the effect of the pandemic era on this situation. METHODS: A total of 1,425 people (18-80 years old) were included in this study. The types of questions like the province where they live, age, gender, occupation, education status, and the presence of chronic diseases, as well as knowing which vaccines are used in adult vaccination, which of these vaccines they had in the last 10 years, which ones they plan to have this year, and whether COVID-19 pandemic changed their perspective on adult vaccinations or not were asked to people. RESULTS: In the last 10 years, while participants stated that they had the highest rate of tetanus vaccine with 29.8%, hepatitis B vaccine with 23.1%, influenza vaccine with 22.7%, human papillomavirus vaccine with 1.3%, and zoster vaccine with 0.3% were the lowest levels of vaccines. CONCLUSIONS: As a result, it seems that we are far from the goals set by the health authorities for adult vaccination. We observed that the COVID-19 pandemic raised awareness toward pneumococcus and influenza vaccines and interest toward adult vaccinations and at the same time changed the thoughts against adult vaccinations.
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    PublicationOpen Access
    Markers predicting critical illness and mortality in COVID-19 patients: A multi-centre retrospective study
    (2021-01-01T00:00:00Z) Büyükaydın, Banu; Karaaslan, Tahsin; Karatoprak, Cumali; Karaaslan, Esra; Sasak Kuzgun, Gulsah; Gündüz, Mehmet; Şekerci, Abdusselam; Alişir Ecder, Sabahat; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; BÜYÜKAYDIN, BANU
    Aim: In this study, we aimed to investigate early predictors of critical illness and mortality in patients with coronavirus disease 2019 (COVID-19) based onclinical, biochemical, radiological, and epidemiological findings.Materials and Methods: This multi-center, retrospective study was conducted in three centers and included a total of 206 confirmed COVID-19 cases usingreverse transcription-polymerase chain reaction (RT-PCR). Data of survivors and non-survivors were compared, and predictors of mortality were examined.Results: Among the patients, 103 (50%) were males with a mean age of 52.8±16.7 years; 88.3% of the patients were discharged in a healthy condition, while11.7% died. The mean age was significantly higher in non-survivors. Dyspnea occurred in 32.5% of patients, and a significant correlation was found betweendyspnea and mortality (p<0.001). Thoracic computed tomography (CT) findings were positive in 88.8% of patients. The most frequent imaging findings wereground-glass opacities in 86.4% and consolidation in 33% of patients. The mortality rate was significantly higher in patients with comorbidities (p<0.001).There was also a significant correlation between lymphocytopenia and mortality (p<0.001). A positive correlation was found between mortality risk andplatelet-to-lymphocyte, neutrophil-to-lymphocyte, and red cell distribution width indices. The mortality risk was significantly higher in patients with acutekidney injury (10.7%) (p<0.001).Discussion: These results suggest that advanced age, coexisting diabetes, hypertension, heart failure, chronic kidney disease, or acute kidney injury are associatedwith an increased mortality risk. The presence of dyspnoea or consolidation on thoracic CT can predict an increased mortality risk in COVID-19 patients.
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    Is there a link between neutrophil-lymphocyte ratio and patient compliance with gluten free diet in celiac disease?
    (2016-01-01T00:00:00Z) Uslu, Ali Ugur; Korkmaz, Serdal; Yonem, Ozlem; Aydin, Bahattin; Uncu, Tunahan; Sekerci, ABDÜSSELAM; Topal, Firdevs; ŞENCAN, MEHMET; ŞEKERCİ, ABDÜSSELAM
    © Gülhane Tip Fakültesi 2016.The aim of the present study is to determine the association of neutrophillymphocyte ratio (NLR) as an objective marker for detecting compliance to diet in celiac disease (CD). Thirty-seven patients with CD and 37 healthy volunteers were enrolled to the study. At the end of the first year, the patients were divided into 2 groups considering their compliance with diet. Seven patients, who are not compliant to gluten free diet (GFD), formed the first group (group 1). Thirty patients, who are compliant to GFD, formed the second group (group 2), and 37 healthy volunteers served as the control group (group 3). NLR was significantly higher in the patient group than the controls (p 0.05). At the end of the first year, there were significant differences between group 1 and group 2 (p = 0.007) and between group 1 and group 3 in terms of NLR (p = 0.005). Receiver-operating characteristic curve analysis suggested the optimum NLR cutoff value for patients with GFD incompatible as 2.51, with a sensitivity and specificity of 85 % and 94 %, respectively (area under curve: 0.819, 95 % confidence interval = 0.589-1.000, p = 0.009). NLR may be a promising marker in predicting the patient compliance in patients with CD.