Person: BURSAL DURAMAZ, BURCU
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Publication Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)(2022-02-01T00:00:00Z) Yilmaz Ciftdogan, Dilek; Ekemen Keles, Yildiz; Karbuz, Adem; ÇETİN, BENHUR ŞİRVAN; Elmas Bozdemir, Sefika; KEPENEKLİ KADAYİFCİ, EDA; Metin Akcan, Ozge; Ozer, Arife; Erat, Tugba; Sutcu, Murat; Buyukcam, Ayse; BELET, NURŞEN; Erdeniz, Emine Hafize; Dalgic Karabulut, Nazan; Hancerli Torun, Selda; ÖNCEL, SELİM; ORBAK, Zerrin; TÜREL, Özden; GAYRETLİ AYDIN, ZEYNEP GÖKÇE; KILIÇ, ÖMER; Yahsi, Aysun; Kara Aksay, Ahu; Ergenc, Zeynep; Petmezci, Mey Talip; OFLAZ, MEHMET BURHAN; Sarikaya, Remzi; Otar Yener, Gulcin; Ozen, Seval; Gul, Doruk; ARSLAN, GAZİ; Kara, Soner Sertan; Demirkol, Demet; YAZICI ÖZKAYA, PINAR; YOZGAT, YILMAZ; Varan, Celal; Kara, Manolya; ARGA, GÜL; YAKUT, NURHAYAT; Kilic, Ahmet Osman; ÇAKICI, ÖZLEM; Kucuk, Mehmet; Kaba, Ozge; KARAOĞLU ASRAK, HATİCE; BURSAL DURAMAZ, BURCU; Dalkiran, Tahir; Berna Anil, Ayse; TURĞUT, MEHMET; KARAPINAR, BÜLENT; Somer, Ayper; ELMALI, FERHAN; DİNLEYİCİ, ENER ÇAĞRI; ÇİFTCİ, ERGİN; KARA, ATEŞ; TÜREL, ÖZDEN; YOZGAT, YILMAZ; BURSAL DURAMAZ, BURCUAim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients- medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.Publication Analysis of Meningitis Cases in Pediatric Intensive Care Unit: 8-Year Single Center Experience(2020-03-01T00:00:00Z) BURSAL DURAMAZ, BURCU; Kihtir, Hasan Serdar; Petmezci, Mey Talip; Yesilbas, Osman; Ankay, Nermin; Hatipoglu, Nevin; Sevketoglu, Esra; BURSAL DURAMAZ, BURCUObjective: The aim of the study was to evaluate clinical features, management of intensive care treatment, complications and mortality in children with meningitis treated in pediatric intensive care unit.Publication Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period(2019-03-01T00:00:00Z) Duramaz, Altug; BURSAL DURAMAZ, BURCU; Bilgili, Mustafa G.; BURSAL DURAMAZ, BURCUThere are only a few studies in the literature investigating the effects of gestational age on developmental dysplasia of the hip. The aim of this study was to investigate the effects of gestational age on hip ultrasound findings in the early neonatal period in preterm newborns born between 30th and 36th weeks of gestational age. Between January 2008 and December 2013, a total of 788 hips of 394 premature newborns with a gestational age of up to 36th weeks who underwent hip ultrasonography in the first week of their life were retrospectively examined. The distribution of roof angles and hip types in terms of sexes was compared between groups. Birth weight, birth height, a, and beta angles were analyzed in terms of the gestational age. The mean gestational age was 33.07 weeks (SD 2.09; between 30th and 36th). Six hundred and seven hips were classified as type I, 154 as type IIa, 21 as type IIc, and 6 as type III. In the 30th week, type IIc hips in females and type III hips in males were statistically significantly higher (P=0.001). In the 34th week, type IIc hips in males were statistically significantly higher than the females (P=0.013). In the 35th week, type IIa hips in females hips were statistically significantly higher than the males (P=0.008). Among all preterm infants, type IIc hips were more common in the 30th, 31st, 32nd, and 34th weeks, whereas type III hips were statistically significantly more common in the 30th week (P=0.0001). The 30th, 31st, 32nd, and 34th weeks of age are gestational ages that should be considered in terms of dysplastic and subluxed hips in premature newborns. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.Publication Multicenter prospective surveillance study of viral agents causing meningoencephalitis(2021-03-01T00:00:00Z) Torun, Selda Hancerli; Kaba, Ozge; YAKUT, NURHAYAT; KEPENEKLİ KADAYİFCİ, EDA; Kara, Manolya; Yanartas, Mehpare Sari; Somer, Ayper; BURSAL DURAMAZ, BURCU; TÜREL, Özden; Dalgic, Nazan; Alp, Emel Eksi; Sali, Enes; Cakir, Deniz; Onal, Pinar; ÇOKUĞRAŞ, Haluk Cezmi; Aygun, Fatma Deniz; Karbuz, Adem; Onel, Mustafa; Mese, Sevim; Agacfidan, Ali; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDENThe frequency of bacterial factors causing central nervous system infections has decreased as a result of the development of our national immunization program. In this study, it is aimed to obtain the data of our local surveillance by defining the viral etiology in cases diagnosed with meningoencephalitis for 1 year. Previously healhty 186 children, who applied with findings suggesting viral meningoencephalitis to 8 different tertiary health centers between August 2018 and August 2019, in Istanbul, were included. The cerebrospinal fluid (CSF) sample was evaluated by polymerase chain reaction. The M:F ratio was 1.24 in the patient group, whose age ranged from 1 to 216 months (mean 40.2 +/- 48.7). Viral factor was detected in 26.8%. Enterovirus was the most common agent (24%) and followed by Adenovirus (22%) and HHV type 6 (22%). In the rest of the samples revealed HHV type 7 (10%), EBV (6%), CMV (6%), HSV type 1 (6%), Parvovirus (4%) and VZV (2%). The most common symptoms were fever (79%) and convulsions (45.7%). Antibiotherapy and antiviral therapy was started 48.6% and 4% respectively. Mortality and sequela rate resulted 0.53% and 3.7%, respectively. This highlights the importance of monitoring trends in encephalitis in Turkey with aview to improving pathogen diagnosis for encephalitis and rapidly identifying novel emerging encephalitis-causing pathogens that demand public health action especially in national immunisation programme.Publication Subdural empyema, brain abscess, and superior sagittal sinus venous thrombosis secondary to Streptococcus anginosus(2021-01-01T00:00:00Z) YEŞİLBAŞ, Osman; YOZGAT, Can Yılmaz; Tahaoglu, Irmak; BURSAL DURAMAZ, BURCU; TÜREL, Özden; TEKİN, NUR; UZUNER, SELÇUK; Abdallah, Anas; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDEN; TEKİN, NUR; UZUNER, SELÇUKStreptococcus anginosus can be frequently isolated from brain abscesses, but is a rare cause of the liver, lung, and deep tissue abscesses. In this report, we present a patient with subdural empyema, brain abscess, and superior sagittal cerebral venous thrombosis as complications of rhinosinusitis whose purulent empyema sample yielded S. anginosus. A 13-year-old female patient was referred to our pediatric intensive care unit with altered mental status, aphasia, and behavioral change. On a brain computed tomography scan, subdural empyema extending from the left frontal sinus to the frontal interhemispheric area and left hemispheric dura was detected. Intravenous ceftriaxone, vancomycin, and metronidazole treatments were started. Subdural empyema was surgically drained. Postoperative brain magnetic resonance venography imaging showed superior sagittal sinus thrombosis. Cultures obtained from purulent empyema sample revealed S. anginosus. On the third day of hospitalization, a brain computed tomography scan showed brain edema, especially in the left hemisphere and significantly increased subdural empyema that had been previously drained. She was reoperated and decompressive craniectomy was performed. On the fifth day, partial epileptic seizures occurred. Brain magnetic resonance imaging showed a brain abscess on the interhemispheric area. The magnetic resonance imaging findings of abscess formation improved on 30th day and she was discharged on the 45th day after the completion of antibiotic therapy.Publication Is your diagnosis cat scratch disease, not lymphoma?(2021-05-01T00:00:00Z) TÜREL, Özden; Demir, Aysegul Dogan; ÇAKIR, FATMA BETÜL; BURSAL DURAMAZ, BURCU; Kaba, Ozge; TÜREL, ÖZDEN; ÇAKIR, FATMA BETÜL; BURSAL DURAMAZ, BURCUPublication kronik akciğer hastalığı olan çocuklarda streptococcus pneumonia taşıyıcılığı ve suşların penisilin direnci(2018-09-27T00:00:00Z) Çakır, Erkan; Yazan, Hakan; Semizoğlu, Bahriye; Bursal Duramaz, Burcu; Türel, Özden; ÇAKIR, ERKAN; YAZAN, HAKAN; SEMİZOĞLU, BAHRİYE; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDENPublication The role of psychiatric status on pediatric extremity fractures: a prospective analysis(2019-12-01T00:00:00Z) Duramaz, Altug; Yilmaz, Semra; Ziroglu, Nezih; BURSAL DURAMAZ, BURCU; Bayram, Berhan; Kara, Tayfun; BURSAL DURAMAZ, BURCUPurpose The aim of the study was to investigate the relationship between attention deficit and hyperactivity disorder (ADHD), anxiety, and depression with pediatric extremity fractures. Methods Between November 2014 and November 2016, consecutive 138 patients with pediatric extremity fractures were prospectively investigated in terms of the tendency to anxiety, depression, or ADHD in the study group. Consecutive 168 non-trauma patients who were admitted to general pediatrics outpatient clinic were included the control group. Patients were performed with Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale-Parents Form (T-DSM-IV S), The Screen for Child Anxiety-Related Emotional Disorders (SCARED), and The Children-s Depression Inventory (CDI). Results There were not any significant differences between study and control groups regarding the age, gender distribution, economical level, or previous psychiatric admission rates (p > 0.05). In the study group, the previous ADHD history and previous fracture history were significantly higher than the control group (p < 0.05). In the study group, the severity of depressive signs and anxiety were significantly higher than the control group (p = 0.000 and p = 0.019; respectively). Regarding the previous fracture history, conduct disorder and tendency to depression were significantly higher in the study group (p = 0.001 and p = 0.011; respectively). Conclusions The signs of ADHD, anxiety, and depression were determined to be higher in children with extremity fractures compared with the non-traumatic population. In patients with especially behavioral problems and depressive signs, directing to the child and adolescent psychiatrists will be protective to prevent re-fractures and high-energy traumas.Publication Williams Syndrome Presenting with Intractable Staphylococcus aureus Endocarditis(2020-02-14T04:00:00Z) Yozgat, Can Yilmaz; UZUNER, SELÇUK; Yesilbas, Osman; BURSAL DURAMAZ, BURCU; YOZGAT, Yılmaz; İŞCAN, AKIN; TÜREL, Özden; UZUNER, SELÇUK; YEŞİLBAŞ, OSMAN; BURSAL DURAMAZ, BURCU; YOZGAT, YILMAZ; İŞCAN, AKIN; TÜREL, ÖZDENPublication Active and Latent Tuberculosis in Children Treated with Anti-TNF-alpha: A Retrospective Multicenter Study(2022-02-01T00:00:00Z) Dalgic, Nazan; Sahin, Ayse; Torun, Selda Hancerli; Kaba, Ozge; Onal, Pinar; Yilmaz, Ayse Tekin; TÜREL, Özden; Yasar, Belma; Kara, Manolya; AYGÜN, FATMA DENİZ; Kilinc, Ayse; ÖNCEL, SELİM; BURSAL DURAMAZ, BURCU; Urganci, Nafiye; Somer, Ayper; ÇOKUĞRAŞ, HALUK CEZMİ; ARISOY, EMİN SAMİ; TÜREL, ÖZDEN; BURSAL DURAMAZ, BURCUObjective This study aimed to investigate the frequency of latent and active tuberculosis (TB) in pediatric patients receiving anti-tumor necrosis factor (TNF)-alpha therapy.