Person:
ÖZGEN, İLKER TOLGA

Profile Picture
Status
Kurumdan Ayrılmıştır.
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
İLKER TOLGA
Last Name
ÖZGEN
Name
Email Address
Birth Date

Filters

2013 - 2019122020 - 202210
Reset filters

Settings

Rights: info:eu-repo/semantics/openAccess ×

Search Results

Now showing 1 - 10 of 22
  • Thumbnail Image
    PublicationOpen Access
    Pseudohypoparathyroidism Type Ia with Normocalcemia
    (2019-04-01T00:00:00Z) Kutlu, Esra; CESUR, Yaşar; ÖZGEN, İLKER TOLGA; Yesil, Gozde; KUTLU, ESRA; ÖZGEN, İLKER TOLGA; CESUR, YAŞAR; YEŞİL, GÖZDE
    Pseudohypoparathyroidism (PHP) is a heterogeneous group of disorder with parathormone target organ resistance, characterized by hypocalcemia, hyperphosphatemia and high blood parathormone (PTH). Typical phenotypic symptoms and additional hormonal resistance can be observed in type Ia, which is also known as Albright hereditary osteodystrophy. Our patient was an eight-year and nine-month old girl with typical Albright-s hereditary osteodystrophy phenotype including short stature, obesity, round face, low nasal bridge, shortened metacarpals, and mild mental retardation. In her biochemical examination, high PTH level and hypothyroidism is detected in spite of normal calcium and phosphor levels. As a result of clinic and laboratory tests, the findings were consistent with PHP type Ia with normocalcemia. In her guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 (GNAS 1) gene serial analysis, C-308T>C (p1103T) transformation was detected, which was previously reported in a PHP type Ia patient. In this report, we-ve aimed to emphasize the fact that calcium and phosphor level in the blood of the patient with PHP type Ia can be measured normal.
  • No Thumbnail Available
    PublicationMetadata only
    Çocuğumun Boyu Kısa mı kalacak?
    (2022-09-29) Özgen İ. T.; ÖZGEN, İLKER TOLGA
  • No Thumbnail Available
    PublicationMetadata only
    A case of diabetes and deafness with heteroplasmic mutations in the mitochondrial DNT1 gene
    (2022-09-12) Özgen İ. T.; Bahar S.; Uyanık B.; ÖZGEN, İLKER TOLGA; BAHAR, Semra; UYANIK, BÜLENT
  • Thumbnail Image
    PublicationOpen Access
    Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
    (2015-09-01) Kahraman, Feyza Ustabas; Vehapoglu, Aysel; Ozgen, Ilker Tolga; Terzioglu, Sule; Cesur, YAŞAR; Dundaroz, Rusen; VEHAPOĞLU TÜRKMEN, AYSEL; USTABAŞ KAHRAMAN, FEYZA; ÖZGEN, İLKER TOLGA; TERZİOĞLU, ŞULE; CESUR, YAŞAR; İŞCAN, AKIN
    Objective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
  • No Thumbnail Available
    PublicationMetadata only
    İrisinin Puberte Prekoks Patofizyolojisindeki Rolünün Dişi Sıçanlarda İncelenmesi
    (2020-10-30) Kutlu E.; Özgen İ. T.; Bulut H.; ÖZGEN, İLKER TOLGA
  • No Thumbnail Available
    PublicationMetadata only
    Growth curves for Turkish Girls with Turner Syndrome: Results of the Turkish Turner Syndrome Study Group.
    (2015-09-01T00:00:00Z) DARENDELILER, F; YEŞILKAYA, E; BEREKET, A; BAŞ, F; BUNDAK, R; SARı, E; Küçükemre, Aydın; DARCAN, Ş; DÜNDAR, B; BÜYÜKINAN, M; KARA, C; MAZıCıOĞLU, MM; ADAL, E; AKıNCı, A; ATABEK, ME; DEMIREL, F; ÇELIK, N; ÖZKAN, B; ÖZHAN, B; ORBAK, Z; ERSOY, B; DOĞAN, M; ATAŞ, A; TURAN, S; GÖKŞEN, D; TARıM, Ö; YÜKSEL, B; ERCAN, O; HATUN, Ş; ŞIMŞEK, E; ÖKTEN, A; ABACı, A; DÖNERAY, H; ÖZBEK, MELİKE; KESKIN, M; ÖNAL, H; AKYÜREK, N; BULAN, K; TEPE, D; EMEKSIZ, HC; DEMIR, K; KıZıLAY, D; TOPALOĞLU, AK; EREN, E; ÖZEN, S; DEMIRBILEK, H; ABALı, S; AKıN, L; EKLIOĞLU, BS; KABA, S; ANıK, A; BAŞ, S; UNUVAR, T; SAĞLAM, H; BOLU, S; Özgen, T; DOĞAN, D; ÇAKıR, ED; ŞEN, Y; ANDıRAN, N; ÇIZMECIOĞLU, F; EVLIYAOĞLU, O; KARAGÜZEL, G; PIRGON, Ö; ÇATLı, G; CAN, HD; GÜRBÜZ, F; BINAY, Ç; BAŞ, VN; SAĞLAM, C; GÜL, D; POLAT, AYTEN; ACıKEL, C; CINAZ, P; ÖZBEK, MELİKE; ÖZGEN, İLKER TOLGA; POLAT, AYTEN
  • No Thumbnail Available
    PublicationMetadata only
  • No Thumbnail Available
    PublicationMetadata only
    Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease.
    (2014-12-01T00:00:00Z) Torun, EMEL; Aydin, Sinem; Gokce, Selim; Ozgen, Ilker Tolga; Donmez, Tugrul; Cesur, Yasar; TORUN, EMEL; AYDIN, SİNEM; ÖZGEN, İLKER TOLGA; CESUR, YAŞAR
    Background/Aims: This study aimed to understand the role of non-alcoholic fatty liver disease (NAFLD) in increasing the risk of atherosclerosis in obese pediatric patients.
  • Thumbnail Image
    PublicationOpen Access
    Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease
    (2014-01-01) Torun, EMEL; Ozgen, Ilker Tolga; Gokce, Selim; Aydin, SİNEM; Cesur, YAŞAR; TORUN, EMEL; ÖZGEN, İLKER TOLGA; VEHAPOĞLU TÜRKMEN, AYSEL; AYDIN, SİNEM; CESUR, YAŞAR
    Objective: We aimed to determine the association of thyroid functions with the components of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) in pediatric obese patients. Methods: The study included 109 obese children (aged 9-15 years) and a control group of 44 healthy age and gender-matched children of normal weight. NAFLD was diagnosed by conventional ultrasound examination. We assessed the anthropometric data and serum biochemical parameters including lipid profile, alanine aminotransferase (ALT), fasting glucose and insulin levels and thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) levels. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as a measure of IR. Results: The mean age and gender distributions in the groups were similar (p=0.23). The mean body mass index (BMI) z-scores of obese children with grade 2-3 NAFLD were significantly higher than those of the obese children without hepatic steatosis (p<0.001). Mean ALT, triglyceride (TG) and LDL cholesterol increased and HDL-cholesterol significantly decreased as the hepatic steatosis increased (p<0.05). HOMA-IR levels in obese subjects with grade 2-3 NAFLD were significantly higher than those in both obese children without NAFLD and grade 1 NADFL (p=0.05 and 0.001, respectively). In the obese subjects, TSH levels were increased significantly as the degree of steatosis increased (p=0.04) but fT3 and fT4 levels were not different. In correlation analysis, TSH was significantly correlated with ALT, BMI SDS and the degree of steatosis. Conclusions: Obese children demonstrate an increase in TSH levels as the degree of steatosis increased.
  • No Thumbnail Available
    PublicationMetadata only
    A novel heterozygous STAT5B variant in a patient with resistant atopic dermatitis and short stature
    (2022-09-15) Bahar S.; Özgen İ. T.; Uyanık B.; BAHAR, Semra; ÖZGEN, İLKER TOLGA; UYANIK, BÜLENT
    Introduction: Growth hormone (GH) exerts its effect through insulin-like growth factor 1 (IGF-I), an intracellular signalling molecule whose production is stimulated by STAT-5b after bind ing to the growth hormone receptor. STAT-5b deficiency, is char acterized by short stature, immune dysregulation and chronic lung disease. And these occur as a result of disruption of the growth hormone axis. Our case is an example of STAT-5b gene mutation, which is a rare disease and it has been defined for the last 10 years. Case: A 12-year-old male patient was admitted to our outpa tient clinic with complaints of short stature and skin rash. He was born 900 gr by cesarean section at 26th gestational week and had a 3-month neonatal intensive care hospitalization history. He was hospitalized with severe acute bronchiolitis attack twice, 1 year and 2.5 years old. He was followed up with diagnosis of atopic derma titis and hyperimmunoglobulin E for the last 3 years. In the family history; his mother’s and father’s height were 150 cm and 175 cm respectively, there was no consanguinity between mother andfather, and he had 2 healthy siblings. Anthropometric measure ments; his height, weight and body mass index were 134 cm (SDS: -1.9), 25.7 kg (SDS: -2.54), and 14.2 kg/m2 (SDS: -2.15) respec tively. The mid parental height SDS of the patient was -1.17. In his physical examination; he had erythematous eczematous lesions around the eyes, cheeks and chin, and xerosis on the hands, promi nent forehead and saddle nose. His testicular volumes were 4/4 ml and pubic hair was tanner stage 1. Laboratory examinations revealed low IGF level (98.7 ng/ml SDS: -1.67) and IGF binding protein 3 (IGFBP3) level (3.75 ng/L SDS: -3.56). Bone age was 8 years-old. GH stimulation tests with L-dopa revealed low basal GH levels and reduced GH response (peak GH of 2.24 ng/ml). Prolactin level was found to be 12.3ug/l. Height velocity was 6 cm per year. A new heterozygous STAT5b mutation (C.1906+1G>A) was detected.