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ÖZGEN, İLKER TOLGA

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İLKER TOLGA
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Author: Ozgen, Ilker Tolga ×

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    SIRT1 gene variants are related to risk of childhood obesity
    (2015-04-01) Kilic, Ulkan; GOK, Ozlem; ELIBOL-CAN, BİRSEN; Ozgen, Ilker Tolga; Erenberk, UFUK; Uysal, Omer; DUNDAROZ, Mehmet Rusen; ELİBOL, BİRSEN; ÖZGEN, İLKER TOLGA; ERENBERK, UFUK; UYSAL, ÖMER
    Obesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p T. There was no significant difference for rs7069102 C > G gene polymorphism between groups.
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    PublicationOpen Access
    Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
    (2015-09-01) Kahraman, Feyza Ustabas; Vehapoglu, Aysel; Ozgen, Ilker Tolga; Terzioglu, Sule; Cesur, YAŞAR; Dundaroz, Rusen; VEHAPOĞLU TÜRKMEN, AYSEL; USTABAŞ KAHRAMAN, FEYZA; ÖZGEN, İLKER TOLGA; TERZİOĞLU, ŞULE; CESUR, YAŞAR; İŞCAN, AKIN
    Objective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
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    Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease.
    (2014-12-01T00:00:00Z) Torun, EMEL; Aydin, Sinem; Gokce, Selim; Ozgen, Ilker Tolga; Donmez, Tugrul; Cesur, Yasar; TORUN, EMEL; AYDIN, SİNEM; ÖZGEN, İLKER TOLGA; CESUR, YAŞAR
    Background/Aims: This study aimed to understand the role of non-alcoholic fatty liver disease (NAFLD) in increasing the risk of atherosclerosis in obese pediatric patients.
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    PublicationOpen Access
    Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease
    (2014-01-01) Torun, EMEL; Ozgen, Ilker Tolga; Gokce, Selim; Aydin, SİNEM; Cesur, YAŞAR; TORUN, EMEL; ÖZGEN, İLKER TOLGA; VEHAPOĞLU TÜRKMEN, AYSEL; AYDIN, SİNEM; CESUR, YAŞAR
    Objective: We aimed to determine the association of thyroid functions with the components of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) in pediatric obese patients. Methods: The study included 109 obese children (aged 9-15 years) and a control group of 44 healthy age and gender-matched children of normal weight. NAFLD was diagnosed by conventional ultrasound examination. We assessed the anthropometric data and serum biochemical parameters including lipid profile, alanine aminotransferase (ALT), fasting glucose and insulin levels and thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) levels. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as a measure of IR. Results: The mean age and gender distributions in the groups were similar (p=0.23). The mean body mass index (BMI) z-scores of obese children with grade 2-3 NAFLD were significantly higher than those of the obese children without hepatic steatosis (p<0.001). Mean ALT, triglyceride (TG) and LDL cholesterol increased and HDL-cholesterol significantly decreased as the hepatic steatosis increased (p<0.05). HOMA-IR levels in obese subjects with grade 2-3 NAFLD were significantly higher than those in both obese children without NAFLD and grade 1 NADFL (p=0.05 and 0.001, respectively). In the obese subjects, TSH levels were increased significantly as the degree of steatosis increased (p=0.04) but fT3 and fT4 levels were not different. In correlation analysis, TSH was significantly correlated with ALT, BMI SDS and the degree of steatosis. Conclusions: Obese children demonstrate an increase in TSH levels as the degree of steatosis increased.
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    An investigation of the foot ankle joint mobility, muscle strength, and foot structure in adolescent with type 1 diabetes
    (2018-01-01) Mutlu, Ebru Kaya; Unver, Banu; Taskiran, Hanifegul; Ozgen, Ilker Tolga; ÖZGEN, İLKER TOLGA
    Muscle strength and joint mobility were decreased with type 1 diabetes mellitus (T1DM). However, the literature is limited about foot muscle strength, joint mobility, and structure in adolescent aged 13-17 with T1DM. The purpose of this study was to compare foot structure, muscle strength, and joint mobility of adolescents aged between 13 and 17 with T1DM to those of healthy adolescents. Cross-sectional study design including adolescents with T1DM aged 13-17 years, and healthy adolescents was used in the study. The range of motion (ROM) was measured by using a digital goniometer, and muscle strength was evaluated by using handheld-dynamometry. Footprint was used for foot structure. Assessments were performed by using the digital images, and Clarke-s angle (CA), Staheli Arch index (SAI), and Chippaux-Smirak index (CSI) were calculated by using a scientific image-analysis program, ImageJ. Forty-one T1DM and 28 healthy adolescents were included with a mean age of 15.29 +/- 1.55 and 15.04 +/- 1.42, respectively. The T1DM group had significantly lower dorsiflexion, inversion and eversion ROM, and lower tibialis anterior and gastrocnemius muscle test (p 0.05). Adolescents with T1DM have lower ankle and foot joint mobility and muscle strength and altered foot structure compared to their healthy contemporaries. This indicates that early screening of muscle strength and foot structure are important to determine and avoid various risks such as foot deformities, gait deviations, and ulcer.
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    PublicationOpen Access
    Vitamin D Deficiency and Insufficiency in Obese Children and Adolescents and Its Relationship with Insulin Resistance
    (2013-01-01) Torun, EMEL; GONULLU, Erdem; Ozgen, Ilker Tolga; CINDEMIR, Ergul; OKTEM, Faruk; TORUN, EMEL; ÖZGEN, İLKER TOLGA
    Objectives. We aimed to determine the relationship between insulin resistance and serum 25-hydroxyvitamin D (25-OHD) levels in obese children and their nonobese peers. Materials and Methods. Included in the study group were 188 obese children (aged 9-15 years), and 68 age- and gender-matched healthy children of normal weight as control group. Anthropomorphic data were collected on patients and fasting serum glucose, insulin, serum lipids, alanine aminotransaminase (ALT) and 25-OHD were measured. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated in both groups. Results. The levels of 25-OHD in the obese group were significantly lower than those of the nonobese (P = 0.002). HOMA-IR, triglycerides, low-density lipoprotein, and ALT levels in the obese group were significantly higher than values of control group (P < 0.001 and P = 0.002, resp.). In the obese group, vitamin D deficiency, insufficiency, and sufficiency (25-OHD < 10 ng/dl, < 20, >10 ng/dl; > 20 ng/dl, resp.) were not correlated with HOMA-IR (r : -0.008, P = 0.935). HOMA-IR was negatively correlated with BMI, BMI SDS, and BMI%, and triglycerides, low-density lipoprotein, and ALT levels (P < 0.001). Conclusion. The insulin resistance of the obese subjects who were vitamin D deficient and insufficient did not statistically differ from those with vitamin D sufficiency. Low 25-hydroxyvitamin D levels were not related with higher insulin resistance in obese children and adolescents. In obese subjects, insulin resistance was affected more from BMI, BMI SDS, and BMI% than from 25-hydroxyvitamin D levels.
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    Trace Elements in Obese Turkish Children
    (2011-10-01T00:00:00Z) TASCILAR, Mehmet Emre; Ozgen, Ilker Tolga; ABACI, Ayhan; SERDAR, Muhittin; AYKUT, Osman; ÖZGEN, İLKER TOLGA
    The quality of the diet of obese children is poor. Eating habits may alter micronutrient status in obese patients. In this study, we determined the serum levels of selenium, zinc, vanadium, molybdenum, iron, copper, beryllium, boron, chromium, manganese, cobalt, silver, barium, aluminum, nickel, cadmium, mercury, and lead in obese Turkish children. Thirty-four obese and 33 healthy control subjects were enrolled in the study. Serum vanadium and cobalt levels of obese children were significantly lower than those of the control group (0.244 +/- 0.0179 vs. 0.261 +/- 0.012 mu g/l, p < 0.001, and 0.14 +/- 0.13 vs. 0.24 +/- 0.15 mu g/l, p = 0.011, respectively). There was no significant difference between groups regarding the other serum trace element levels. In conclusion, there may be alterations in the serum levels of trace elements in obese children and these alterations may have a role in the pathogenesis of obesity.
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    The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents
    (2013-05-01) Torun, EMEL; GENC, Habibe; GONULLU, Erdem; AKOVALI, Burak; Ozgen, Ilker Tolga; TORUN, EMEL; ÖZGEN, İLKER TOLGA
    Aim: To evaluate the clinical and biochemical findings of the children and adolescents with vitamin D deficiency and insufficiency in order to determine the clinical and biochemical presentation differences between age groups.
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    Oxidative stress in obese children and its relation with insulin resistance
    (2012-04-01) Ozgen, Ilker Tolga; TASCILAR, Mehmet Emre; Bilir, Pelin; BOYRAZ, Mehmet; GUNCIKAN, Mustafa Nuri; AKAY, Cemal; DUNDAROZ, Rusen; ÖZGEN, İLKER TOLGA
    Background: In obese populations, oxidative stress plays a major role in the pathogenesis of serious diseases such as diabetes, coronary heart disease, and atherosclerosis. In this study, we investigated the status of oxidative stress in obese children as to nitrite/nitrate and glutathione peroxidase levels, and their relation with insulin resistance (IR).
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    Pediatric reference intervals of free thyroxine and thyroid stimulating hormone in three different hospitals
    (2018-10-01) Aral, Hale; Ozer, Omer Faruk; Onur, Hatice; ÇİLİNGİRTÜRK, AHMET METE; Ozgen, Ilker Tolga; Ayyıldız, Mevlude; ÖZER, ÖMER FARUK; ÖZGEN, İLKER TOLGA
    Objective: Using data retrieved from three different hospitals, we established indirect reference intervals of free thyroxine (FT4) and thyroid stimulating hormone (TSH) for the Centaur XP or the Immulite 2000 instruments, in separate reference limits at each subset.