Person: BULUT, HURI
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Publication Metadata only Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells(2018-05-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KARATAŞ, Ersin; CAGLAR, Hifa; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BULUT, HURIPublication Metadata only Beyin Metastazlı Hastalarda Gamma Knife Radyocerrahisinin ve Tüm Beyin Işınlamasının İmmün Sistem İlişkili Proteinler Üzerine Etkilerinin İncelenmesi(2018-04-20) Koçyiğit, Abdurrahim; GÜLER, ERAY METİN; Akdur, Kerime; Şakarcan, Ayten; ÖZEK, ERDİNÇ; BULUT, HURİ; MAYADAĞLI, ALPASLAN; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BULUT, HURI; MAYADAĞLI, ALPASLAN; SEYİTHANOĞLU, MEHMET HAKANPublication Metadata only A new approach to recurrent pregnancy losses: anti-cardiolipin-specific peptide screening with phage display technique(2017-09-01) Yuksel, B.; Şahin, Deniz; BULUT, HURİ; Kocyigit, ABDÜRRAHİM; BULUT, HURI; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only IŞKIN KÖKÜ EKSTRESİNİN MALİGN MELANOM HÜCRELERİ ÜZERİNE ANTİ-KANSER ETKSİNİN ARAŞTIRILMASI(2018-10-31) KİRMİT, ADNAN; KOÇYİĞİT, ABDÜRRAHİM; TAKIM, KASIM; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; GÜLER, ERAY METİN; BALKAN, EZGİ; KOÇYİĞİT, ABDÜRRAHİM; BULUT, HURI; GÜLER, ERAY METİN; BALKAN, EZGİPublication Metadata only NAD DEPENDENT FORMATE DEHYDROGENASE PRODUCTIONAND ENHANCEMENT OF ACTIVITY VIA PROTEIN ENGINEERING(2018-10-30T00:00:00Z) BULUT, HURİ; Yüksel, Büşra; Isupov, Michail; EREN, MERYEM; yelmazer, Berin; BİNAY, BARIŞ; Littlechild, Jennifer; KOÇYİĞİT, ABDÜRRAHİM; BULUT, HURI; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only The Effects of Thymoquinone via High Mobility Group Box-1Protein on Apoptosis and Oxidative Stress in ExperimentalSpinal Cord Injury(2017-09-01T00:00:00Z) ÇALIŞ, FATİH; AKKAYA, ENES; EVRAN, ŞEVKET; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; GÜREL GÜREVİN, EBRU; ÇEVİK, SERDAR; HANIMOĞLU, HAKAN; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; KAYNAR, MEHMET YAŞAR; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; BULUT, HURI; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells(2019-09-01) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; GÜLER, Eray Metin; BULUT, HURİ; KÖKTAŞOĞLU, FATMANUR; Goeren, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHANMany studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.Publication Metadata only Role of Urotensin-2 in 5-Fluorouracil-Related Arterial Vasoconstriction in Cancer Patients(2018-01-01) Seker, MESUT; ISEN, Hayati C.; Cevirme, NİDAL; Aydin, Sinem; Bilici, Ahmet; COBAN, EZGİ; Bulut, HURİ; YASIN, Ayse I.; Demir, TARIK; Aliyev, ALTAY; Kocyigit, ABDÜRRAHİM; Turk, Haci M.; ŞEKER, MESUT; ÇEVİRME, NİDAL; BULUT, HURI; ÇOBAN, EZGİ; DEMİR, TARıK; ALİYEV, ALTAY; KOÇYİĞİT, ABDÜRRAHİM; TÜRK, HACI MEHMETBackground: The aim of this study was to identify the possible relationship of 5-fluorouracil (5-FU)-related arterial vasoconstriction with urotensin-2 (UT-2), which has a high potential as an endogenic vasoconstrictor. Methods: We assigned the patients to 1 of 3 groups. Patients in group 1 received a bolus of 5-FU, those in group 2 a continuous infusion (CI) of 5-FU, and those in group 3 no 5-FU, which was also a control group. Pre- and post-treatment UT-2 levels and brachial arterial diameters were measured and recorded in all patients. Results: 132 patients were included in the study. Pre-and post-treatment brachial artery diameters were similar in all groups: in group 1 (3.28 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.740), in group 2 (3.57 +/- 0.47 vs. 3.46 +/- 0.45 mm, p = 0.441) and in the control group (3.51 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.818). Pre-and post-treatment UT-2 levels were significantly different in each group: in group 1 (39.5 +/- 30.9 vs. 56.7 +/- 27.1 ng/ml, p = 0.0001), in group 2 (37.7 +/- 33.7 vs. 62.5 +/- 37.7 ng/ml, p = 0.0001) and in the control group (52.9 +/- 40.2 vs. 60.8 +/- 40.7 ng/ml, p = 0.006). Conclusion: Our findings suggest that UT-2 has a high potential as a vasoconstrictor agent in our bodies and its level increases through a bolus or CI 5-FU. Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis. (c) 2018 S. Karger GmbH, FreiburgPublication Metadata only The Acorn Honey Used for a Published Study was Mistakenly Listed as Quercus pyrenaica and Should Be Corrected to Quercus species(2022-07-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; YENİGÜN, Vildan Betül; GÜLER, ERAY METİN; BULUT, Huri; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN