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KINA, ÜMİT YAŞAR

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ÜMİT YAŞAR
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KINA
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    Genetic disruption of nucleoside transporter 4 reveals its critical roles in malaria parasite sporozoite functions.
    (2022-08-24T00:00:00Z) Deveci, GÖZDE; Kamil, Mohd; Kina, Umit; Temel, Binnur Aydogan; Aly, Ahmed S I; DEVECİ, GÖZDE; KAMIL, MOHD; KINA, ÜMİT YAŞAR; TEMEL, BİNNUR
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    Assessing the influence of cycloastragenol on telomere/telomerase system of Arabidopsis thaliana
    (2021-03-01T00:00:00Z) Ceylan, Merve; KINA, ÜMİT YAŞAR; Cakir, Ozgur; Kara, Neslihan Turgut; KINA, ÜMİT YAŞAR
    Cycloastragenol (CAG) is a triterpenoid saponin compound that is synthesized by Astragalus species. CAG has many bioactivity, including telomerase activation, telomere elongation, anti-inflammatory, and anti-oxidative properties. While CAG activates human telomerase, no study has been conducted to investigate its effect on the plant telomere/telomerase system. In this study, in order to test whether CAG has an impact on plants, 1 mu M and 10 mu M CAG were tested on all in vitro grown plant and callus tissues of a model plant Arabidopsis thaliana. Results revealed that CAG caused an increase in the transcript levels of TER1, CTC1, TRB1, POT1a, TAC1, BT2 which act as positive regulators on the telomere/telomerase system together with the TERT gene encoding the catalytic subunit of telomerase especially calli tissues in A.thaliana. While CAG administration resulted in increase in height, and no remarkable effect on callus growth index was observed. Furthermore, no significant change in cell proliferation was observed in plant root cells due to the CAG treatment. The gene expression results suggest that CAG induced transcription of positive regulators of telomere/telomerase system and it might have a role in plants as well as in humans.
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    Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite
    (2022-12-01T00:00:00Z) KAMIL, MOHD; KINA, ÜMİT YAŞAR; DEVECİ, GÖZDE; Akyuz, Sevim N.; Yilmaz, Ilknur; ALY, Ahmed Sayed Ibrahım; KAMIL, MOHD; KINA, ÜMİT YAŞAR; DEVECİ, GÖZDE; ALY, AHMED SAYED IBRAHıM
    © 2022Positively-charged polyamines are essential molecules for the replication of eukaryotic cells and are particularly important for the rapid proliferation of parasitic protozoa and cancer cells. Unlike in Trypanosoma brucei, the inhibition of the synthesis of intermediate polyamine Putrescine caused only partial defect in malaria parasite blood-stage growth. In contrast, reducing the intracellular concentrations of Spermidine and Spermine by polyamine analogs caused significant defects in blood-stage growth in Plasmodium yoelii and P. falciparum. However, little is known about the synthesizing enzyme of Spermidine and Spermine in the malaria parasite. Herein, malaria parasite conserved Spermidine Synthase (SpdS) gene was targeted for deletion/complementation analyses by knockout/knock-in constructs in P. yoelii. SpdS was found to be essential for blood-stage growth. Live fluorescence imaging in blood-stages and sporozoites confirmed a specific mitochondrial localization, which is not known for any polyamine-synthesizing enzyme so far. This study identifies SpdS as an excellent drug targeting candidate against the malaria parasite, which is localized to the parasite mitochondrion.