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YURDAKUL, OZAN VOLKAN

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OZAN VOLKAN
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YURDAKUL
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    Beyond expectations: disease duration and psychological burden in psoriatic arthritis.
    (2023-07-07) Kılıç G.; Kılıç E.; Tekeoğlu İ.; Sargın B.; Cengiz G.; Balta N. C.; Alkan H.; Kasman S. A.; Şahin N.; Orhan K.; Gezer İ. A.; Keskin D.; Mülkoğlu C.; Reşorlu H.; Ataman Ş.; Bal A.; Duruöz M. T.; Küçükakkaş O.; Şen N.; Toprak M.; Yurdakul O. V.; Melikoğlu M. A.; Ayhan F. F.; Baykul M.; Bodur H.; Çalış M.; Çapkın E.; Devrimsel G.; Hizmetli S.; Kamanlı A.; Keskin Y.; Ecesoy H.; Kutluk Ö.; Şendur Ö. F.; Tolu S.; Tuncer T.; Nas K.; YURDAKUL, OZAN VOLKAN; KÜÇÜKAKKAŞ, OKAN; KESKİN, YAŞAR
    This study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classifcation criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (<5 years), middle stage (≥5,<10 years), and late stage (≥10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR=1.52), PsAQoL (OR=1.13), HAQ (OR=1.99), FiRST score (OR=1.14), unemployment/retired (OR=1.48) and PASI head score (OR=1.41) were factors that infuenced the risk of depression, whereas the current or past enthesitis (OR=1.45), PsAQoL (OR=1.19), and FiRST score (OR=1.26) were factors that infuenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.
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    Evaluation of the physical and emotional effects of the COVID-19 pandemic on patients with fibromyalgia and chronic low back pain: A multicenter cross-sectional controlled study
    (2022-09-01) Bagcier, Fatih; Kibar, Sibel; Evcik, Deniz; Ketenci, Ayşegül; Sindel, Dilşad; Tur, Birkan Sonel; Ünlü, Zeliha; Tıkız, Canan; Keskin, Dilek; Alp, Alev; Ay, Saime; Yanık, Burcu; Geler Külcü, Duygu; Karakaş, Merve; Ural Nazlıkul, Fatma Gülçin; Kurt Oktay, Kübra Neslihan; Kasapoğlu Aksoy, Meliha; Fındıkoğlu, Gülin; Eser, Filiz; Atıcı, Arzu; Yurdakul, Ozan Volkan; Aybala Koçak, Fatmanur; Kurt, Emine Eda; Özkan, Yasemin; Koldaş Doğan, Şebnem; Erdem Sultanoğlu, Tuba; Ordahan, Banu; Karaca Umay, Ebru; Demirhan, Esma; Çağlar Yağcı, Hanife; Balbaloğlu, Özlem; Tezel, Nihal; Satış, Serap; Atar, Sevgi; Akaltun, Mazlum Serdar; YURDAKUL, OZAN VOLKAN
    Objectives: This study aimed to investigate the physical and emotional effects of the coronavirus disease 2019 pandemic in patients with fibromyalgia syndrome (FMS) and chronic low back pain (CLBP) patients. Patients and methods: The cross-sectional controlled study was performed with 1,360 participants (332 males, 1,028 females; mean age: 42.3±12.5 years; range, 18 to 65 years) between September 2020 and February 2021. The participants were evaluated in three groups: the FMS group (n=465), the CLBP group (n=455), and the healthy control group (n=440). Physical activity, pain levels, and general health status before and during the pandemic were evaluated in all participants. Stress levels were analyzed with the perceived stress scale (PSS) in all groups, and disease activity was analyzed with the fibromyalgia impact questionnaire (FIQ) in patients with FMS. Results: Patients with FMS had worsened general health status and pain levels during the pandemic compared to the other groups (p< 0.01). The FMS group showed significantly higher PSS scores than those in other groups (p< 01). There was a weak-positive correlation between FIQ and PSS parameters in patients with FMS (p< 0.05, r=0.385). Conclusion: The general health status, pain, and stress levels of the patients with FMS and CLBP tended to worsen during the pandemic. This high-stress level appeared to affect disease activity in patients with FMS.
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    Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis.
    (2022-12-01) Küçükakkaş O.; Aydin T.; Yurdakul O. V.; YURDAKUL, OZAN VOLKAN
    Femoral cartilage thickness may be an important objective parameter in detecting the progression of knee osteoarthritis(KOA). In this study, we aimed to examine the possible effects of intra-articular Hyaluronic Acid(HA) and platelet-rich plasma(PRP) injections on femoral cartilage thickness and to investigate their possible superiority over each other in KOA. A total of 40 KOA patients were included in the study and randomized to the HA and PRP groups. Pain complaints, stiffness, and functional status were evaluated with the Visual Analog Scale(VAS) and Western Ontario and Mc Master Universities Osteoarthritis(WOMAC) indices. Ultrasonography was used for measuring the femoral cartilage thickness. At the 6th month measurements, significant improvements were observed in VAS-rest, VAS-movement, and WOMAC scores in both HA and PRP groups compared to the measurements performed before the treatment. No significant difference was observed between the effects of the two treatment methods. There were significant changes in the medial, lateral and mean cartilage thicknesses on the symptomatic knee side in the HA group. The most important finding of this prospective randomized study, in which we compared the effects of PRP and HA injections on KOA, was the increase in knee femoral cartilage thickness in the HA injection group. This effect started in the 1st month and continued until the 6th month. No similar effect was detected with PRP injection. In addition to this basic result, both treatment approaches had significant positive effects on pain, stiffness, and function and no superiority was observed over each other.