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KOÇHAN, KORAY

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KORAY

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KOÇHAN

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Now showing 1 - 10 of 21
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    Results of nucleos(t)ide analog treatment discontinuation in hepatitis b e-Antigen-negative chronic hepatitis b: Nucstop study
    (2024-01-01) Kiremitci S.; Kochan K.; SEVEN G.; Keskin E. B.; OKAY G.; AKKOYUNLU Y.; Koc M. M.; SÜMBÜL B.; ŞENTÜRK H.; KİREMİTÇİ, SERCAN; KOÇHAN, KORAY; SEVEN, GÜLSEREN; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKAN
    Background/Aims: This study aims to investigate the effects of nucleos(t)ide analogs (NAs) discontinuation in eligible patients in accordance with the Asian Pacific Association for the Study of the Liver hepatitis B guideline and the factors affecting clinical and virological relapses. Materials and Methods: In this prospectively designed study, hepatitis B e antigen (HBeAg)-negative chronic hepatitis B patients who were followed up between 2012 and 2019 were evaluated and 57 patients were included. All participants enrolled the study were HBeAgnegative status at NA initiation. Results: The median age of the patients was 49 (29-72) years and 24 (42%) were females. The median treatment duration was 96 (36-276) months and patients were followed for a median duration of 27 months. Sixteen patients had a previous history of NA switch, and thirteen of these patients had a history of lamivudine resistance. Thirty-eight of 57 patients (66%) developed an elevated hepatitis B virus deoxyribonucleic acid level of 2000 IU/mL at least once, defined as virological relapse and 23 (60%) of them, experienced clinical relapse. Thirty-one of 57 patients were re-Treated during the follow-up, and hepatitis B surface antigen (HBsAg) loss occurred among 4 (7%) patients. All patients who experienced HBsAg loss had a history of lamivudine resistance (P = .002). Conclusion: Despite receiving NAs suppression therapy for a long time, HBsAg loss occurs rarely. Although it was not life-Threatening, most patients experienced relapses and treatment should be restarted. In our study, whether it is a coincidence that all patients with HBsAg loss are patients in whom NAs are used sequentially due to lamivudine resistance is an issue that needs to be further investigated.
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    Pankreas kistlerinde tersiyer merkez deneyimimiz
    (2018-10-14T00:00:00Z) koray, koçhan; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; ünver, nurcan; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; KOÇHAN, KORAY; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
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    Pankreas Kistlerinde müsinöz/nonmüsinöz ayırımında string testin yararı ve aspirat CEA ölçümü ile karşılaştırılması
    (2017-12-06T00:00:00Z) koçhan, koray; BİBERCİ KESKİN, ELMAS; ünver, nurcan; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; KOÇHAN, KORAY; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
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    Early prediction of the severe course, survival, and ICU requirements in acute pancreatitis by artificial intelligence
    (2023-01-01) İnce A. T.; Silahtaroğlu G.; Seven G.; Koçhan K.; Yıldız K.; Şentürk H.; İNCE, ALİ TÜZÜN; SEVEN, GÜLSEREN; KOÇHAN, KORAY; ŞENTÜRK, HAKAN
    AbstractObjectiveTo evaluate the success of artificial intelligence for early prediction of severe course, survival, and intensive care unit(ICU) requirement in patients with acute pancreatitis(AP).MethodsRetrospectively, 1334 patients were included the study. Severity is determined according to the Revised Atlanta Classification(RAC). The success of machine learning(ML) method was evaluated by 13 simple demographic, clinical, etiologic, and laboratory features obtained on ER admission. Additionally, it was evaluated whether Balthazar-computerized tomography severity index(CTSI) at 48-h contributed to success. The dataset was split into two parts, 90% for ML(of which 70% for learning and 30% for testing) and 10% for validation and 5-fold stratified sampling has been utilized. Variable Importance was used in the selection of features during training phase of machine. The Gradient Boost Algorithm trained the machine by KNIME analytics platform. SMOTE has been applied to increase the minority classes for training. The combined effects of the measured features were examined by multivariate logistic regression analysis and reciever operating curve curves of the prediction and confidence of the target variables were obtained.ResultsAccuracy values for the early estimation of Atlanta severity score, ICU requirement, and survival were found as 88.20%, 98.25%, and 92.77% respectively. When Balthazar-CTSI score is used, results were found as 91.02%, 92.25%, and 98% respectively.ConclusionsThe ML method we used successfully predicted the severe course, ICU requirement and survival, with promising accuracy values of over 88%. If 48-h Balthazar-CTSI is included in the calculation, the severity score and survival rates increase even more.
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    Ampulla Vateri Tümörlerinde Endoskopik Rezeksiyon: Tek Merkezden 62 Hastanın Uzun Dönem Sonuçları
    (2022-11-22) Koçhan K.; Biberci Keskin E.; Şentürk H.; KOÇHAN, KORAY; BİBERCİ KESKİN, ELMAS; ŞENTÜRK, HAKAN
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    Serum Histon H3.3 ve H4’xxün Kronik Hepatit B ile ilişkisi
    (2018-11-25T00:00:00Z) koçhan, koray; İNCE, ALİ TÜZÜN; BİBERCİ KESKİN, ELMAS; gültepe, bilge; KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜN; BİBERCİ KESKİN, ELMAS; KOÇHAN, KORAY; KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKAN
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    The relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B
    (2020-09-01T00:00:00Z) Sümbül, Bilge; Şentürk, Hakan; Köker, İbrahim Hakkı; Koçhan, Koray; İnce, Ali Tüzün; Biberci Keskin, Elmas; İNCE, ALİ TÜZÜN; BİBERCİ KESKİN, ELMAS; SÜMBÜL, BİLGE; KOÇHAN, KORAY; KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKAN
    Objective: To determine the role of serum histone H3.3 and H4 in patients with chronic hepatitis B to explore any relationship between the two.Methods: The prospective controlled clinical pilot study was conducted in the Gastroenterology Clinic of Bezmialem Vakif University, Istanbul, Turkey, from January to October 2017, and comprised biopsy-proven patients with chronic hepatitis B and healthy controls. Demographics, hepatitis B virus deoxyribonucleic acid quantity, hepatitis B e-antigen, aspartate aminotransferase, alanine transaminase, international normalized ratio, total/direct bilirubin, albumin and thrombocyte counts as well as histological activity index and fibrosis scores were noted. Data was analysed using SPSS 22.Results: Of the 140 subjects, 70(50%) each were cases and controls. The overall mean age of the sample was 43.38±15.07 years (range: 18-70 years). There was positive correlation of histone H3.3 with hepatitis B virus deoxyribonucleic acid, aspartate aminotransferase, alanine transaminase and international normalized ratio levels. Histone H4 levels only correlated with hepatitis B virus deoxyribonucleic acid and international normalized ratio. Hepatitis B e-antigen positivity was present in 14(20%) of the cases.Conclusion: Histone H3.3 levels appeared to be associated with pathophysiological changes in chronic hepatitis B patients, suggesting that future treatments should target H3.3.Keywords: Histone H3.3, Histone H4, Extracellular histone, Chronic Hepatitis B, HBV.(JPMA 70: 1596; 2020)DOI:https://doi.org/10.5455/JPMA.19365
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    UTILIZATION OF ENDOSCOPIC ULTRASONOGRAPHY IN GASTROINTESTINAL STROMAL TUMORS: RETROSPECTIVE ANALYSIS OF A LARGE CASE SERIES
    (2019-06-01T00:00:00Z) KOÇHAN, KORAY; AKPINAR, ATİLLA; Keskin, Elmas; KÖKER, İBRAHİM HAKKI; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; KOÇHAN, KORAY; AKPINAR, ATİLLA; BİBERCİ KESKİN, ELMAS; KÖKER, İBRAHİM HAKKI; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
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    Relationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activity
    (2013-09-01T00:00:00Z) Yesil, Atakan; GÖNEN, Can; Senates, Ebubekir; Paker, Nurcan; Gokden, Yasemin; Kochan, KORAY; Erdem, Emrullah Duzgun; Gunduz, Feyza; KOÇHAN, KORAY
    Background and Aim Neutrophil gelatinase associated lipocalin (NGAL) is a recently identified molecule, which is bacteriostatic, has tissue destructive effects and is proinflammatory with chemoattractant molecule binding properties. Our aim was to investigate the relationship between serum NGAL levels and the type and level of disease activity of IBD.
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    Sa1359 – Cholecystitis in Pancreatic Carcinoma: A Poorly Recognized Condition with High Rate of Sepsis Related Mortality Cholecystitis in Pancreatic Carcinoma: A Poorly Recognized Condition with High Rate of Sepsis Related Mortality.
    (2019-05-28T00:00:00Z) Koçhan, Koray; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; İNCE, ALİ TÜZÜN; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; KOÇHAN, KORAY; BİBERCİ KESKİN, ELMAS; İNCE, ALİ TÜZÜN; BAŞARANOĞLU, METİN