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ÖZTURAN, ORHAN

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ORHAN
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ÖZTURAN
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    PublicationOpen Access
    Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.
    (2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHAN
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    PublicationOpen Access
    Angiofibroma Localized in the Sphenoid Sinus
    (2017-01-01) Yenigun, ALPER; Aksoy, Fadlullah; Vural, Omer; Ozturan, ORHAN; YENİGÜN, ALPER; AKSOY, FADLULLAH; VURAL, ÖMER; ÖZTURAN, ORHAN
    Juvenile nasopharyngeal angio-broma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. (e gold standard treatment method is the surgical excision of the tumor. (is case report is a case of angio-broma, a 32-year-old asymptomatic male patient with no evidence of clinical signs and endoscopic examination, which is recognized as a localized vascular mass lesion in the right sphenoid sinus on the cranial MR imaging. We prepared this case report that may represent an angio-broma localized only within the sphenoid sinus which is very rare in the literature.
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    PublicationOpen Access
    Connecticut (CCCRC) Olfactory Test: Normative Values in 426 Healthy Volunteers
    (2014-01-01) VEYSELLER, Bayram; OZUCER, Berke; KARAALTIN, Aysegul Batioglu; YILDIRIM, Yalcin; DEGIRMENCI, NAZAN; AKSOY, Fadlullah; ÖZTURAN, ORHAN; DEĞİRMENCİ, NAZAN; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    Application of Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test to healthy Turkish volunteers, obtain normative data set and analyse the role of age, sex and smoking on olfactory scores. The present study was conducted at Bezmialem Vakif University, Department of Otorhinolaryngology. Total of 426 healthy volunteers were subjected to CCCRC olfactory test which consists of n-butanol smell threshold test and smell identification test. Olfactory function score was assessed (0: worst score; 7: best score) and mean scores were calculated. Mean age was (36.7 ± 11.1; range, 17–68). 46.2 % of the subjects were male and 53.8 % were female; 37.1 % were smokers and 62.9 % were nonsmokers. Mean n-butanol threshold score was 6.36 out of 7, mean identification score was 6.34 and mean total score was 6.35. According to CCCRC score: there were no anosmic individuals, 0.5 % were severely hyposmic, 2.6 % were moderately hyposmic,15.3 % were mildly hyposmic and 81.6 % were normosmic. CCCRC olfactory test is cost-effective, simple and practical. It can be easily applied in clinical settings. The CCCRC olfactory test is appropriate for assessment of olfactory function: Turkish population is familiar in terms of the odors used in CCCRC test. The power of this study is that it provides a normative data set against which many factors can be compared.
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    PublicationOpen Access
    Association of accessory sphenoid septa with variations in neighbouring structures
    (2017-01-01) AKSOY, FEYZA MÜBERRA; ÖZTURAN, ORHAN; GOKTAS, S.S.; YENİGÜN, ALPER; YENİGÜN, ALPER; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
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    PublicationOpen Access
    The Need for Completion Thyroidectomy in Cases of Differentiated Thyroid Cancer
    (2017-02-01) VEYSELLER, BAYRAM; ÖZTURAN, ORHAN; YENİGÜN, ALPER; MERİÇ HAFIZ, AYŞENUR; AKSOY, MEHMET FADLULLAH; YENİGÜN, ALPER; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    There are no definitive criteria for the presence of malignancy in the opposite lobe in cases of unilateral lobectomy due to a thyroid mass in which the malignancy was diagnosed histologically. Study design is retrospective, cross sectional study. The present study included patients who underwent a lobectomy in our clinic between 2001 and 2016 with an initial diagnosis of atypia with undetermined significance or suspected malignancy according to fine-needle aspiration biopsy and adult patients who received a thyroidectomy based on thyroid cancer detected in pathological examinations. Tumor histopathological diagnosis, tumor size, and capsular, vascular, or lymphatic invasion were assessed in patients who received thyroid lobectomy. The presence of a multifocal tumor (52.3%) significantly increased the risk of malignancy in the opposite lobe over the risk association with a unifocal tumor (8.9%; p < 0001). In patients with a tumor diameter greater than 4 cm (83.3%), the risk of malignancy in the opposite lobe was higher than that in patients with a tumor diameter less than 4 cm (22.3%; p < 0.001). Significant differences were not observed between groups with and without vascular or capsular invasion of the opposite lobe (p = 0.913 and p = 0.840, respectively). We determined risk factors for the presence of multifocal disease in unilateral lobectomy materials; an aggressive tumor subtype and a size larger than 4 cm are the most important factors that increase the risk of malignancy in the opposite lobe. Level of evidence Level 4-Case-control studies.
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    PublicationOpen Access
    Otoacoustic Emission Responses of the Cochlea to Acute and Total Ischemia
    (2013-12-01) Yildirim, YAVUZ SELİM; AKSOY, Fadlullah; Ozturan, ORHAN; VEYSELLER, Bayram; DEMIRHAN, Hasan; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    In the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3–8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling of the cochlear vasculature and surrounding structures is necessary in surgical interventions. Additionally, our results provide some idea of the normal tolerance range of the cochlea to ischemia, which could be useful for future studies
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    PublicationOpen Access
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    PublicationOpen Access
    Letter to the Editor regarding article by Hussein et al. doi:10.1007/s00405-014-3309-7
    (2015-10-01) Eren, SABRİ BAKİ; TUGRUL, Selahattin; OZUCER, Berke; Meric, Aysenur; Ozturan, ORHAN; EREN, SABRİ BAKİ; MERİÇ HAFIZ, AYŞENUR; ÖZTURAN, ORHAN
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    PublicationOpen Access
    The benefit of replacing the excess costal cartilage in rhinoplasty
    (2022-03-01T00:00:00Z) ÖZTURAN, ORHAN; YENİGÜN, ALPER; YURTSEVER, İSMAİL; ÖZDEM, ABDULLAH; YILDIZ, KEMALETTİN; ÖZTURAN, ORHAN; YENİGÜN, ALPER; YURTSEVER, İSMAİL; ÖZDEM, ABDULLAH; YILDIZ, KEMALETTİN
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    PublicationOpen Access
    Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity.
    (2020-03-17T00:00:00Z) Elbay, A; Yenigun, A; Ozturan, O; Bayraktar, H; Ozer, Ömer Faruk; Dogan, R; YENİGÜN, ALPER; ELBAY, AHMET; ÖZDEM, ABDULLAH; ÖZER, ÖMER FARUK; DOĞAN, REMZI; ÖZTURAN, ORHAN
    Objective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants (P ¼ .001, P ¼ .038). In blood osmolarity measurements, there was no statistical difference between the groups (P ¼ .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants (P ¼ .001, P ¼ .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants (P ¼ .001, P ¼ .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.