Person:
ÖZTURAN, ORHAN

Profile Picture
Google ScholarScopusORCIDPublons
Status
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
ORHAN
Last Name
ÖZTURAN
Name
Email Address
Birth Date

Filters

2012 - 201911
Reset filters

Settings

Author: Ozturan, ORHAN × Rights: info:eu-repo/semantics/openAccess ×

Search Results

Now showing 1 - 10 of 11
  • Thumbnail Image
    PublicationOpen Access
    Angiofibroma Localized in the Sphenoid Sinus
    (2017-01-01) Yenigun, ALPER; Aksoy, Fadlullah; Vural, Omer; Ozturan, ORHAN; YENİGÜN, ALPER; AKSOY, FADLULLAH; VURAL, ÖMER; ÖZTURAN, ORHAN
    Juvenile nasopharyngeal angio-broma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. (e gold standard treatment method is the surgical excision of the tumor. (is case report is a case of angio-broma, a 32-year-old asymptomatic male patient with no evidence of clinical signs and endoscopic examination, which is recognized as a localized vascular mass lesion in the right sphenoid sinus on the cranial MR imaging. We prepared this case report that may represent an angio-broma localized only within the sphenoid sinus which is very rare in the literature.
  • Thumbnail Image
    PublicationOpen Access
    Otoacoustic Emission Responses of the Cochlea to Acute and Total Ischemia
    (2013-12-01) Yildirim, YAVUZ SELİM; AKSOY, Fadlullah; Ozturan, ORHAN; VEYSELLER, Bayram; DEMIRHAN, Hasan; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    In the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3–8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling of the cochlear vasculature and surrounding structures is necessary in surgical interventions. Additionally, our results provide some idea of the normal tolerance range of the cochlea to ischemia, which could be useful for future studies
  • Thumbnail Image
    PublicationOpen Access
  • Thumbnail Image
    PublicationOpen Access
    Effect of Radiofrequency on DNA Damage and Oxidative Status in Patients with Turbinate Hypertrophy.
    (2019-11-01) Tugrul, S; Koçyiğit, A; Senturk, E; Doğan, Remzi; Eren, SB; Ozturan, ORHAN; Kesgin, S; ŞENTÜRK, EROL; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİM
    The radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.
  • Thumbnail Image
    PublicationOpen Access
    Olfactory Dysfunction and Olfactory Bulb Volume Reduction in Patients with Leprosy
    (2012-09-01) VEYSELLER, Bayram; AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; ACIKALIN, R. Murat; GURBUZ, Defne; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
    To ascertain the level and rate of olfactory dysfunction in patients with leprosy and to determine whether olfactory bulb volume is affected by the pathophysiology. Olfactory bulb (OB) volume, measured using magnetic resonance imaging (MRI), was compared in 15 patients with leprosy and 15 healthy controls. All of the participants were evaluated using a detailed history to identify the probable causes of the smell dysfunction. Those who had a disease other than leprosy that may have caused the smell dysfunction were excluded from the study. OB volumes were calculated by manually tracing the OB on coronal sections. Orthonasal olfaction testing was used to assess smell function. The orthonasal olfaction testing indicated that all patients with leprosy were anosmic or severely hyposmic. The smell function test indicated that the OB volume of the patient group was significantly lower than that of the control group. No within-group difference was detected between right and left OB volume in either group. The patients in the leprosy group were severely hyposmic or anosmic and their olfactory bulb volume was significantly lower than that of the control group. To our knowledge, this study is the first to show a reduction in olfactory bulb volume among leprosy patients.
  • Thumbnail Image
    PublicationOpen Access
    Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique
    (2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜL
    Objective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.
  • Thumbnail Image
    PublicationOpen Access
    An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
    (2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUK
    Objectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.
  • Thumbnail Image
    PublicationOpen Access
    Schwannoma Located in Nasopharyngeal Region.
    (2016-01-01) AKSOY, FEYZA MÜBERRA; SENTURK, EROL; Ozturan, ORHAN; YENIGUN, A; AKSOY, FADLULLAH; YENİGÜN, ALPER; ŞENTÜRK, EROL; ÖZTURAN, ORHAN
    Schwannoma is a tumor which has neuroectoderm origins, is hard, well-circumscribed, encapsulated, and slow growing benign cranial tumor, and may autonomously grow out of the nerve sheath of peripheral nerves. It is mostly seen in the head and neck region. In the paranasal sinus and nose areas, it is seen at a rate of 4%. The diagnosis is mostly made after histopathological examination. In this paper, a Schwannoma case observed in the nasopharyngeal region was presented in a 20-year-old female who had complaints of sleeping with open mouth, snoring, foreign body feeling in throat, and swallowing difficulties. The tumor was extracted via transoral approach. No recurrence was observed during follow-up over the next year. This case presentation is presented for the first time in the literature in English.
  • Thumbnail Image
    PublicationOpen Access
    Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis.
    (2016-01-01) VURAL, O; VEYSELLER, B; YENIGUN, A; Ozturan, ORHAN; YENİGÜN, ALPER; VURAL, ÖMER; ÖZTURAN, ORHAN
    The term necrotizing fasciitis was described initially by Wilson in the 1950s [1]. Necrotizing fasciitis is a rapid spreading disease of the soft tissue, which includes the superficial fascia and subcutaneous layer of tissue [2–4]. Necrotizing fasciitis is associated with some situations in which the immune system is compromised, including diabetes mellitus (DM), elderly, acute, or chronic renal disease, postpartum period, alcoholism, intravenous (IV) drug use, malnutrition, malignancy, peripheral vascular disease, and radiation exposure [5]. Necrotizing fasciitis diagnosis is based on certain clinical features that include fulminant progression, presence of greyblack necrotic area, and easy separation of the superficial layers of the underlying tissue [2, 6]. Necrotizing fasciitis can emerge from a local infection region after a minor trauma, which leads to the entrance of site of the infection. The exact etiology of one-third of the necrotizing fasciitis patients is not clear [2, 3, 6]. If necrotizing fasciitis is not diagnosed and treated early, it is potentially a fatal disease [4, 7, 8]. This situation is based on the absence of early clinical findings, rapid progression of the disease, and the delay of surgical intervention [9]. Therefore, experience in the diagnosis and treatment of necrotizing fasciitis is quite limited. Involvement of the head and neck region is quite rare for necrotizing fasciitis patients [2]. In this region there are two types of necrotizing fasciitis and they include cervical and craniofacial involvement [10]. Mortality rates of cervical necrotizing fasciitis range from 7% to 20% depending on the width of the cervical lesion [11]. This case report is presented because, unlike most of the others, this case of necrotizing fasciitis is nonodontogenic, sialoadenitis induced cervical necrotizing fasciitis.
  • Thumbnail Image
    PublicationOpen Access
    Letter to the editor on -The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats-
    (2017-09-01) Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN