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KÖKTAŞOĞLU, FATMANUR

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FATMANUR
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KÖKTAŞOĞLU
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2023 - 20243
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    PublicationOpen Access
    Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease
    (2023-06-01) Demirel M.; Köktaşoğlu F.; Özkan E.; Dulun Ağaç H.; Gül A. Z.; Sharifov R.; Sarıkaya U.; Başaranoğlu M.; Selek Ş.; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; BAŞARANOĞLU, METİN; SELEK, ŞAHABETTİN
    Objectives: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of excessive fat in the liver, which can lead to fibrosis and has an increasing prevalence. NAFLD requires non-invasive diagnostic biomarkers. While typically observed in overweight individuals, it can also occur in non-obese/non-overweight individuals. Comparative studies on non-obese NAFLD patients are scarce. This study aimed to conduct a using liquid chromatography-high resolution mass spectrometry (LC-MS/MS)-based metabolic profiling of non-obese NAFLD patients and healthy controls. Materials and methods: The patient group consisted of 27 individuals with NAFLD, while the healthy control group included 39 individuals. Both groups were between 18 and 40 years old, had a BMI of less than 25 and had alcohol consumption less than 20 g/week for men and 10 g/week for women. Serum samples were collected and analyzed using LC-MS/MS. The data were analyzed using the TidyMass and MetaboAnalyst. Results: The LC-MS/MS analyses detected significant changes in D-amino acid metabolism, vitamin B6 metabolism, apoptosis, mTOR signaling pathway, lysine degradation, and phenylalanine metabolism pathways in non-obese NAFLD patients. Significant changes were also observed in the metabolites D-pantothenic acid, hypoxanthine, citric acid, citramalic acid, L-phenylalanine, glutamine, and histamine-trifluoromethyl-toluidide, β-hydroxymyristic acid, DL-Lactic acid, and 3-methyl-2-oxopentanoic. Overall, the study provides valuable insights into the metabolic changes associated with non-obese NAFLD patients and can contribute to the development of non-invasive diagnostic biomarkers for NAFLD.
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    Hedera helix (Wall Ivy) leaf ethanol extract shows cytotoxic and apoptotic effects in glioblastoma cells by generating reactive oxygen species
    (2023-12-01) Yenigün V. B.; Koçyiğit A.; Kanımdan E.; Durmuş E.; Köktaşoğlu F.; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; KANIMDAN, EBRU; BALKAN, EZGİ; KÖKTAŞOĞLU, FATMANUR
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    Oxidative Stress, Serum Mineral and Trace Element Levels in Patients with Multiple Sclerosis with or without Restless Legs Syndrome
    (2024-01-01) Akçin Ş.; Gürsoy A. E.; SELEK Ş.; ÇİMEN Y. A.; KÖKTAŞOĞLU F.; MERAL İ.; ÜSTÜNOVA S.; GÜRSOY, AZIZE ESRA; SELEK, ŞAHABETTİN; ÇİMEN, YASİN ALİ; KÖKTAŞOĞLU, FATMANUR; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ
    Multiple sclerosis (MS) is a central nervous system disease characterized by inflammation, axonal demyelination and multifocal plaques. Sleep problems due to restless legs syndrome (RLS) are frequently encountered in MS patients. Changes in oxidative stress level and liver enzyme activity and deterioration of trace element homeostasis are observed in MS and RLS patients. This study was conducted to determine serum oxidative stress parameters and trace element levels in MS patients with and without RLS. Thirty healthy individuals (control), 30 MS patients without RLS (MS group) and 30 MS patients with RLS (MS+RLS group) were included in the study. Serum oxidative stress parameters (total antioxidant and oxidant capacities, myeloperoxidase and catalase activities), some liver enzymes (malate dehydrogenase and isocitrate dehydrogenase) activities, blood trace element (copper, zinc and iron) and mineral (calcium, chlorine, magnesium, sodium, potassium) levels were measured. There was no statistically significant difference between the groups in terms of oxidative stress parameters and liver enzymes. Serum chlorine, potassium and sodium levels were higher in the MS+RLS group compared to the controls (p<0.001, p<0.01, p<0.001, respectively), and the zinc level was lower than the control group (p<0.05). Sodium and chlorine levels were higher in the MS+RLS group than in the MS group (p<0.01, p<0.05, respectively). Based on these results, varying trace element levels may have value for early prediction of RLS in MS. In studies with larger sample sizes, changing element and liver enzyme activities in the context of oxidative stress may provide clearer information about the diagnosis of RLS.