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KÖKTAŞOĞLU, FATMANUR

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FATMANUR
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KÖKTAŞOĞLU
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2020 - 202414
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Start date: 2020 × End date: 2024 ×

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Now showing 1 - 10 of 14
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    G6PD AND GAPDH AS POTENTIAL DIAGNOSTIC BIOMARKERS FOR IRON DEFICIENCY ANEMIA
    (2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Gül, Ayşe Zehra; Köktaşoğlu, Fatmanur; Sarıkaya, Ufuk; Yıldız, Tuğçe; Dulun Ağaç, Halime; DEMİREL, METİN; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; KÖKTAŞOĞLU, FATMANUR; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DULUN AĞAÇ, HALİME
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    SERUM REFERENCE INTERVALS OF ZINC AND COPPER IN HEALTHY SUBJECTS OF TURKEY POPULATION
    (2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Yıldız, Tuğçe; Sönmez, Rana; Gül, Ayşe Zehra; Sarıkaya, Ufuk; Köktaşoğlu, Fatmanur; DEMİREL, METİN; SELEK, ŞAHABETTİN; YILDIZ, TUĞÇE; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; KÖKTAŞOĞLU, FATMANUR
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    ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia
    (2021-12-01T00:00:00Z) Atakul, Nil; Atamer, Yildiz; SELEK, ŞAHABETTİN; Kilic, Berna; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR
    The aim of this study was to investigate known cardiovascular disease (CVD) risk biomarkers galectin-3 (Gal-3) and human stromelysin-2 (ST2) levels in preeclampsia (PE) and normotensive pregnancies. A case-control study was conducted in a teaching and research hospital. We performed data analysis involving 45 pregnant women with PE and gestational week (GW) matched 35 normotensive pregnant women. The Gal-3 and ST2 levels were determined by using ELISA kit. Gal-3 values did not differ statistically between PE and control groups (535.1 ng/mL vs. 615.2 ng/mL) (p> .05). ST2 value in the PE group was statistically significantly lower than the control group (33.3 pg/mL vs. PE, 54.5 pg/mL, p 34 GW patients (late-onset PE) had statistically significantly lower Gal-3 values than the <= 34 GW patients (early-onset PE) (507.1 ng/mL vs. 769.6 ng/mL, p < .05). Late-onset PE patients had significantly lower ST2 values than early-onset patients (26.4 pg/mL vs. 57.9 pg/mL, p < .05). We assume that low Gal-3 values in early-onset PE show a higher risk of cardiac fibrosis although both early and late-onset PE patients had an increased CVD risk later in life. We found the superiority of ST2 levels to Gal-3 levels in PE pregnancies for CVD risk assessment.Impact Statement What is already known about this subject? Preeclampsia (PE) in pregnancy is a known risk factor for future cardiovascular disease (CVD) and is also associated with increased mortality from ischaemic heart disease later in life. Studies that investigate patients with a higher risk for CVD in PE pregnancies are lacking. What do the results of this study add? We found different levels of two novel cardiac markers with PE and normotensive pregnancies, and also with early and late-onset PE pregnancies. What are the implications of these findings for clinical practice and/or further research? Different adaptive responses from patients during PE pregnancies via altered levels of cardiac markers could help clinicians to identify women with a higher risk of CVD.
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    PublicationOpen Access
    Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease
    (2023-06-01) Demirel M.; Köktaşoğlu F.; Özkan E.; Dulun Ağaç H.; Gül A. Z.; Sharifov R.; Sarıkaya U.; Başaranoğlu M.; Selek Ş.; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; BAŞARANOĞLU, METİN; SELEK, ŞAHABETTİN
    Objectives: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of excessive fat in the liver, which can lead to fibrosis and has an increasing prevalence. NAFLD requires non-invasive diagnostic biomarkers. While typically observed in overweight individuals, it can also occur in non-obese/non-overweight individuals. Comparative studies on non-obese NAFLD patients are scarce. This study aimed to conduct a using liquid chromatography-high resolution mass spectrometry (LC-MS/MS)-based metabolic profiling of non-obese NAFLD patients and healthy controls. Materials and methods: The patient group consisted of 27 individuals with NAFLD, while the healthy control group included 39 individuals. Both groups were between 18 and 40 years old, had a BMI of less than 25 and had alcohol consumption less than 20 g/week for men and 10 g/week for women. Serum samples were collected and analyzed using LC-MS/MS. The data were analyzed using the TidyMass and MetaboAnalyst. Results: The LC-MS/MS analyses detected significant changes in D-amino acid metabolism, vitamin B6 metabolism, apoptosis, mTOR signaling pathway, lysine degradation, and phenylalanine metabolism pathways in non-obese NAFLD patients. Significant changes were also observed in the metabolites D-pantothenic acid, hypoxanthine, citric acid, citramalic acid, L-phenylalanine, glutamine, and histamine-trifluoromethyl-toluidide, β-hydroxymyristic acid, DL-Lactic acid, and 3-methyl-2-oxopentanoic. Overall, the study provides valuable insights into the metabolic changes associated with non-obese NAFLD patients and can contribute to the development of non-invasive diagnostic biomarkers for NAFLD.
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    TAM-OTOMATİK İZOSİTRAT DEHİDROGENAZ ENZİM AKTİVİTESİ ÖLÇÜM KİTİNİN GELİŞTİRİLMESİ
    (2021-05-03T00:00:00Z) Köktaşoğlu, Fatmanur; Çağlar, Hifa Gülru; KÖKTAŞOĞLU, FATMANUR
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    Investigation of serum enzyme activities and oxidative stress markers in preeclampsia: a multiparameter analysis
    (2022-06-01T00:00:00Z) Selek, Şahabettin; Gül, Ayşe Zehra; Atakul, Nil; Meydan, Sedat; Sarıkaya, Alime; Köktaşoğlu, Fatmanur; Atamer, Yıldız; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; MEYDAN, SEDAT; KÖKTAŞOĞLU, FATMANUR
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    METABOLIC PROFILING STUDY IN SERUM OF PATIENTS WITH POLYCYSTIC KIDNEY DISEASE AND CHRONIC KIDNEYDISEASE BASED ON 1 H NMR SPECTROSCOPY
    (2021-10-11T00:00:00Z) Köktaşoğlu, Fatmanur; Demirel, Metin; Gül, Ayşe Zehra; Elçioğlu, Ömer Celal; Aris, Özlem; Selek, Şahabettin; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; GÜL, AYŞE ZEHRA; ELÇİOĞLU, ÖMER CELAL; SELEK, ŞAHABETTİN
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    Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome
    (2022-01-01T00:00:00Z) ATAKUL, NİL; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; KILIÇ, BERNA ŞERMİN; GÜL, AYŞE ZEHRA; ATAMER, YILDIZ; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; GÜL, AYŞE ZEHRA
    Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology.
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    PublicationOpen Access
    Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss
    (2020-07-01T00:00:00Z) Baki, Ahmet; ÖZER, Ömer Faruk; Yildiz, Muhammet; KÖKTAŞOĞLU, FATMANUR; ÖZER, ÖMER FARUK; KÖKTAŞOĞLU, FATMANUR
    Objective: This study aimed to investigate the serum melatonin levels of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study enrolled 22 patients with ISSNHL and 22 asymptomatic healthy volunteers. The subjects underwent pure tone audiometry and serum melatonin levels were measured. Results: The patient group was composed of 12 women (mean age, 46.41 +/- 7.8) and 10 men (mean age, 48 +/- 6.46), and the control group was composed of 12 women (mean age, 40.25 +/- 5.28) and 10 men (mean age, 38.4 +/- 27.08). The serum melatonin levels were significantly lower in the patient group than in the control group (p=0.001). A statistically significant strong negative correlation was found between serum melatonin level and severity of hearing loss (r=-0.644; p=0.001). Conclusion: Serum melatonin levels of patients with ISSNHL were lower than controls. A statistically significant strong negative correlation was found between serum melatonin level and the severity of hearing loss.
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    The Acorn Honey Used for a Published Study was Mistakenly Listed as Quercus pyrenaica and Should Be Corrected to Quercus species
    (2022-07-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; YENİGÜN, Vildan Betül; GÜLER, ERAY METİN; BULUT, Huri; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN