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KÖKTAŞOĞLU, FATMANUR

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KÖKTAŞOĞLU
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End date: 2024 × Start date: 2020 × Type: Article ×

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Now showing 1 - 5 of 5
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    ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia
    (2021-12-01T00:00:00Z) Atakul, Nil; Atamer, Yildiz; SELEK, ŞAHABETTİN; Kilic, Berna; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR
    The aim of this study was to investigate known cardiovascular disease (CVD) risk biomarkers galectin-3 (Gal-3) and human stromelysin-2 (ST2) levels in preeclampsia (PE) and normotensive pregnancies. A case-control study was conducted in a teaching and research hospital. We performed data analysis involving 45 pregnant women with PE and gestational week (GW) matched 35 normotensive pregnant women. The Gal-3 and ST2 levels were determined by using ELISA kit. Gal-3 values did not differ statistically between PE and control groups (535.1 ng/mL vs. 615.2 ng/mL) (p> .05). ST2 value in the PE group was statistically significantly lower than the control group (33.3 pg/mL vs. PE, 54.5 pg/mL, p 34 GW patients (late-onset PE) had statistically significantly lower Gal-3 values than the <= 34 GW patients (early-onset PE) (507.1 ng/mL vs. 769.6 ng/mL, p < .05). Late-onset PE patients had significantly lower ST2 values than early-onset patients (26.4 pg/mL vs. 57.9 pg/mL, p < .05). We assume that low Gal-3 values in early-onset PE show a higher risk of cardiac fibrosis although both early and late-onset PE patients had an increased CVD risk later in life. We found the superiority of ST2 levels to Gal-3 levels in PE pregnancies for CVD risk assessment.Impact Statement What is already known about this subject? Preeclampsia (PE) in pregnancy is a known risk factor for future cardiovascular disease (CVD) and is also associated with increased mortality from ischaemic heart disease later in life. Studies that investigate patients with a higher risk for CVD in PE pregnancies are lacking. What do the results of this study add? We found different levels of two novel cardiac markers with PE and normotensive pregnancies, and also with early and late-onset PE pregnancies. What are the implications of these findings for clinical practice and/or further research? Different adaptive responses from patients during PE pregnancies via altered levels of cardiac markers could help clinicians to identify women with a higher risk of CVD.
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    Investigation of serum enzyme activities and oxidative stress markers in preeclampsia: a multiparameter analysis
    (2022-06-01T00:00:00Z) Selek, Şahabettin; Gül, Ayşe Zehra; Atakul, Nil; Meydan, Sedat; Sarıkaya, Alime; Köktaşoğlu, Fatmanur; Atamer, Yıldız; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; MEYDAN, SEDAT; KÖKTAŞOĞLU, FATMANUR
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    Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome
    (2022-01-01T00:00:00Z) ATAKUL, NİL; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; KILIÇ, BERNA ŞERMİN; GÜL, AYŞE ZEHRA; ATAMER, YILDIZ; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; GÜL, AYŞE ZEHRA
    Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology.
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    Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss
    (2020-07-01T00:00:00Z) Baki, Ahmet; ÖZER, Ömer Faruk; Yildiz, Muhammet; KÖKTAŞOĞLU, FATMANUR; ÖZER, ÖMER FARUK; KÖKTAŞOĞLU, FATMANUR
    Objective: This study aimed to investigate the serum melatonin levels of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study enrolled 22 patients with ISSNHL and 22 asymptomatic healthy volunteers. The subjects underwent pure tone audiometry and serum melatonin levels were measured. Results: The patient group was composed of 12 women (mean age, 46.41 +/- 7.8) and 10 men (mean age, 48 +/- 6.46), and the control group was composed of 12 women (mean age, 40.25 +/- 5.28) and 10 men (mean age, 38.4 +/- 27.08). The serum melatonin levels were significantly lower in the patient group than in the control group (p=0.001). A statistically significant strong negative correlation was found between serum melatonin level and severity of hearing loss (r=-0.644; p=0.001). Conclusion: Serum melatonin levels of patients with ISSNHL were lower than controls. A statistically significant strong negative correlation was found between serum melatonin level and the severity of hearing loss.
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    The Acorn Honey Used for a Published Study was Mistakenly Listed as Quercus pyrenaica and Should Be Corrected to Quercus species
    (2022-07-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; YENİGÜN, Vildan Betül; GÜLER, ERAY METİN; BULUT, Huri; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN