Person: KÖKTAŞOĞLU, FATMANUR
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Publication METABOLIC EFFECTS OF ORAL TITANIUM DIOXIDE IN JUVENILE RATS: INSIGHTS FROM NMR-BASED METABOLOMICS ANALYSIS(2024-02-29) KÖKTAŞOĞLU F.; DEMİREL M.; GÜLTEKİN F.; GÜLER E. M.; BEKİROĞLU S.; SELEK Ş.; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication New zinc assay for automated clinical chemistry analyzers(2019-06-01T00:00:00Z) Koktasoglu, F.; Caglar, H. G.; Sarikaya, A.; Demirel, M.; Gul, A. Z.; Selek, S.; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİNPublication ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia(2021-12-01T00:00:00Z) Atakul, Nil; Atamer, Yildiz; SELEK, ŞAHABETTİN; Kilic, Berna; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANURThe aim of this study was to investigate known cardiovascular disease (CVD) risk biomarkers galectin-3 (Gal-3) and human stromelysin-2 (ST2) levels in preeclampsia (PE) and normotensive pregnancies. A case-control study was conducted in a teaching and research hospital. We performed data analysis involving 45 pregnant women with PE and gestational week (GW) matched 35 normotensive pregnant women. The Gal-3 and ST2 levels were determined by using ELISA kit. Gal-3 values did not differ statistically between PE and control groups (535.1 ng/mL vs. 615.2 ng/mL) (p> .05). ST2 value in the PE group was statistically significantly lower than the control group (33.3 pg/mL vs. PE, 54.5 pg/mL, p 34 GW patients (late-onset PE) had statistically significantly lower Gal-3 values than the <= 34 GW patients (early-onset PE) (507.1 ng/mL vs. 769.6 ng/mL, p < .05). Late-onset PE patients had significantly lower ST2 values than early-onset patients (26.4 pg/mL vs. 57.9 pg/mL, p < .05). We assume that low Gal-3 values in early-onset PE show a higher risk of cardiac fibrosis although both early and late-onset PE patients had an increased CVD risk later in life. We found the superiority of ST2 levels to Gal-3 levels in PE pregnancies for CVD risk assessment.Impact Statement What is already known about this subject? Preeclampsia (PE) in pregnancy is a known risk factor for future cardiovascular disease (CVD) and is also associated with increased mortality from ischaemic heart disease later in life. Studies that investigate patients with a higher risk for CVD in PE pregnancies are lacking. What do the results of this study add? We found different levels of two novel cardiac markers with PE and normotensive pregnancies, and also with early and late-onset PE pregnancies. What are the implications of these findings for clinical practice and/or further research? Different adaptive responses from patients during PE pregnancies via altered levels of cardiac markers could help clinicians to identify women with a higher risk of CVD.Publication G6PD AND GAPDH AS POTENTIAL DIAGNOSTIC BIOMARKERS FOR IRON DEFICIENCY ANEMIA(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Gül, Ayşe Zehra; Köktaşoğlu, Fatmanur; Sarıkaya, Ufuk; Yıldız, Tuğçe; Dulun Ağaç, Halime; DEMİREL, METİN; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; KÖKTAŞOĞLU, FATMANUR; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DULUN AĞAÇ, HALİMEPublication SERUM REFERENCE INTERVALS OF ZINC AND COPPER IN HEALTHY SUBJECTS OF TURKEY POPULATION(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Yıldız, Tuğçe; Sönmez, Rana; Gül, Ayşe Zehra; Sarıkaya, Ufuk; Köktaşoğlu, Fatmanur; DEMİREL, METİN; SELEK, ŞAHABETTİN; YILDIZ, TUĞÇE; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; KÖKTAŞOĞLU, FATMANURPublication Oxidative Stress, Serum Mineral and Trace Element Levels in Patients with Multiple Sclerosis with or without Restless Legs Syndrome(2024-01-01) Akçin Ş.; Gürsoy A. E.; SELEK Ş.; ÇİMEN Y. A.; KÖKTAŞOĞLU F.; MERAL İ.; ÜSTÜNOVA S.; GÜRSOY, AZIZE ESRA; SELEK, ŞAHABETTİN; ÇİMEN, YASİN ALİ; KÖKTAŞOĞLU, FATMANUR; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞMultiple sclerosis (MS) is a central nervous system disease characterized by inflammation, axonal demyelination and multifocal plaques. Sleep problems due to restless legs syndrome (RLS) are frequently encountered in MS patients. Changes in oxidative stress level and liver enzyme activity and deterioration of trace element homeostasis are observed in MS and RLS patients. This study was conducted to determine serum oxidative stress parameters and trace element levels in MS patients with and without RLS. Thirty healthy individuals (control), 30 MS patients without RLS (MS group) and 30 MS patients with RLS (MS+RLS group) were included in the study. Serum oxidative stress parameters (total antioxidant and oxidant capacities, myeloperoxidase and catalase activities), some liver enzymes (malate dehydrogenase and isocitrate dehydrogenase) activities, blood trace element (copper, zinc and iron) and mineral (calcium, chlorine, magnesium, sodium, potassium) levels were measured. There was no statistically significant difference between the groups in terms of oxidative stress parameters and liver enzymes. Serum chlorine, potassium and sodium levels were higher in the MS+RLS group compared to the controls (p<0.001, p<0.01, p<0.001, respectively), and the zinc level was lower than the control group (p<0.05). Sodium and chlorine levels were higher in the MS+RLS group than in the MS group (p<0.01, p<0.05, respectively). Based on these results, varying trace element levels may have value for early prediction of RLS in MS. In studies with larger sample sizes, changing element and liver enzyme activities in the context of oxidative stress may provide clearer information about the diagnosis of RLS.Publication TAM-OTOMATİK İZOSİTRAT DEHİDROGENAZ ENZİM AKTİVİTESİ ÖLÇÜM KİTİNİN GELİŞTİRİLMESİ(2021-05-03T00:00:00Z) Köktaşoğlu, Fatmanur; Çağlar, Hifa Gülru; KÖKTAŞOĞLU, FATMANURPublication Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells(2019-09-01) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; GÜLER, Eray Metin; BULUT, HURİ; KÖKTAŞOĞLU, FATMANUR; Goeren, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHANMany studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.Publication The Acorn Honey Used for a Published Study was Mistakenly Listed as Quercus pyrenaica and Should Be Corrected to Quercus species(2022-07-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; YENİGÜN, Vildan Betül; GÜLER, ERAY METİN; BULUT, Huri; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHANPublication New copper assay for automated clinical chemistry analyzers(2019-06-01T00:00:00Z) Koktasoglu, F.; Sarikaya, A.; Demirel, M.; Gul, A. Z.; Selek, S.; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİN