Person: AYDIN, SERDAR
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Publication Open Access Clinical predictors of successful vaginal myomectomy for prolapsed pedunculated uterine leiomyoma(2018-08-06) Aydın, SERDAR; Göksever, Çelik; MARASLI, MUSTAFA; BAKAR, RABİA ZEHRA; AYDIN, SERDAR; MARAŞLI, MUSTAFA; BAKAR, RABIA ZEHRAObjective: Uterine leiomyomas are the most common pelvic tumor in women. The calculated prevalence of prolapsed pedunculated leiomyoma was 2.5% in patients who underwent surgery. Although vaginal removal is safe and effective, hysterectomy demand is questionable. We aimed to analyze the association between patient characteristics, clinical features of prolapsed pedunculated submucosal leiomyoma, and the probability of successful vaginal myomectomy. Material and Methods: This study was conducted in 35 women who presented with prolapsed pedunculated uterine leiomyoma. Patients were grouped according to the treatment procedure, either vaginal myomectomy or hysterectomy. Results: Hysterectomy was performed in 14 patients and vaginal myomectomy was performed in 21 women. The mean ages and menopausal status were similar. Parity was higher in the hysterectomy group (p=0.02). The preoperative hematocrit value of patients undergoing vaginal myomectomy was significantly lower (p=0.04). There was no significant difference between the groups regarding the largest leiomyoma diameter. However, the median calculated leiomyoma volume was lower in the vaginal myomectomy group (p=0.04). None of the variables were independently associated with successful vaginal myomectomy on multivariable logistic regression analysis. Conclusion: The feasibility and choice of vaginal myomectomy is associated with low parity, absence of coexisting leiomyoma, high volume of leiomyoma estimated via ultrasound measurement, and severe anemia. (J Turk Ger Gynecol Assoc 2018; 19: 146-50) Keywords: Leiomyoma, prolapsed pedunculated submucosal leiomyoma, vaginal myomectomy, hysterectomyPublication Open Access Multifetal gestations with assisted reproductive technique before the single-embryo transfer legislation: obstetric, neonatal outcomes and congenital anomalies.(2016-01-01) Arıoğlu, Aydın; Aydın, SERDAR; SERDAROĞLU, H; AYDIN, SERDARObjective: To compare perinatal, neonatal outcome and congenital anomalies of multiple gestations conceived by means of assisted reproductive techniques with spontaneously conceived multiples before the limitation of number of embryo transfer. Methods: Cases consisted of assisted reproductive technique (ART) multifetal gestations and control group comprised of spontaneously conceived multifetal gestations delivered in the same time period. Outcomes were perinatal, neonatal outcome, long-term outcomes and congenital anomalies of multiple gestations. There were 270 multifetal pregnancies for analysis, of which 137 were achieved by ART and 133 were spontaneous in this prospective study. Results: Incidences of preeclampsia, gestational diabetes, deep vein thrombosis, thrombocytopenia, intrahepatic cholestasis and preterm premature rupture of membranes were similar in ART and spontaneous groups. There was no difference in fetal malformation rates between ART and control group, but higher rates of central nervous system malformation were observed (4 (1.5%) in control, 0 in ART group, p = 0.04) in spontaneous group. No difference was seen in the perinatal mortality. Conclusions: Neonatal and maternal outcomes are comparable between ART and spontaneous multifetal gestations. Congenital fetal malformation rates between ART and spontaneous multifetal pregnancies were similar except central nervous system malformation that was more likely in spontaneously conceived ones.Publication Open Access QT interval changes in term pregnant women living at moderately high altitude(2016-09-01) BATMAZ, G.; AKSOY, A.; Aydin, SERDAR; Dane, B.; AYDIN, SERDAR; KAHRAMAN AY, NURAYObjective: This study aimed to compare the QT interval changes in women with term pregnancy living at moderately high altitude (1890 m in Erzurum, Turkey) with those of women living at sea level (31 m in İstanbul, Turkey). Materials and Methods: One‑hundred ten women (n = 55, for each group) with full‑term and single child pregnancies. Two different locations in that state were selected: İstanbul, Turkey, which is at 31 m above sea level (Group 1) and Erzurum, Turkey, at 1890 m above sea level (Group 2). Physicians from the two locations participated in the study. We estimated QTc, QTc Max, QTc Min, QT, and QTcd intervals. Results: Moderately high altitude group had significantly longer QT parameters (QTc, QTc Max, QTc Min, QT, and QTcd intervals) compared with sea level group (P < 0.01, for all). Conclusions: According to our results, QT interval changes occur in term pregnant women living moderately high altitude. These changes may be associated with pregnancy‑related cardiovascular complications in moderately high altitude.Publication Open Access Development and Validation of Turkish Version of The Female Sexual Distress Scale-Revised.(2016-03-01) Aydın, SERDAR; ONARAN, ÖI; TOPALAN, K; AYDıN, ÇA; Dansuk, RAMAZAN; AYDIN, SERDAR; AYDIN, CEMALETTİN; DANSUK, RAMAZANIntroduction: The sexually related personal distress becomes an obligation for the diagnosis of female sexual dysfunction (FSD). The Female Sexual Distress Scale-Revised (FSDS-R) was developed, extensively validated, and is among the most widely used tools to measure distress associated with impaired sexual function. Aim: This study aims to develop a Turkish version of the FSDS-R, to evaluate its psychometric reliability and validity, and to estimate the optimal cutoff score that corresponds best to the clinical diagnosis of sexual dysfunction. Methods: Ninety-five participants were diagnosed with female sexual interest and arousal disorder (FSIAD), 25 participants were diagnosed with another FSD, and 128 participants were healthy. Alpha coefficients (α) were used as an indicator of internal consistency. Test-retest reliability over a 2-week period was estimated using intraclass correlation coefficients (ICCs). Correlation analysis conducted between the FSDS-R total score, the Female Sexual Function Index subscale, and total score was examined for convergent validity. Discriminant validity was assessed by comparing mean scores of the FSD and control groups in a between-groups analysis of variance. Receiver operating characteristic analysis was performed to determine optimal cutoff values of the Turkish version of Female Sexual Distress Scale-Revised (Tr-FSDS-R). Main outcomes measures: Sexuality-related distress measured by the Turkish version of the FSDS-R. Results: Internal consistencies of the FSDS-R across the two assessments point for the three groups of women ranged from α = 0.87 to α = 0.99. ICCs ranged from 0.92 to 0.94 for baseline and day 15 for FSIAD, other FSD, and no FSD groups. One-factor unidimensional model explained 85.7% of the total variance of the Tr-FSDS-R items. The optimal cutoff score was found to be >11.5 to provide optimal sensitivity (97.9%) and specificity (83.2%). Significant differences in the FSDS-R scores were found between healthy women, women with hypoactive sexual desire disorder, and women with other types of FSD. Conclusion: The Turkish version of FSDS-R is a valid, reliable tool with well discriminative and psychometric validity for use in the Turkish female population and can be used as a screening questionnaire for females with sexual interest/arousal disorder. The score of ≥11.5 was proposed as a cutoff to detect the presence of sexually related personal distress in Turkish women with FSD.Publication Open Access Female sexual distress in infertile Turkish women İnfertil türk kadınlarda cinsel sıkıntı(2015-12-01) AYDIN, SERDAR; KURT, Nihan; MANDEL, Selen; KAPLAN, Mustafa Arda; KARACA, Nilay; Dansuk, RAMAZAN; AYDIN, SERDAR; DANSUK, RAMAZANObjective: To evaluate the effect of infertility on sexual distress in women attending the infertility clinic. Materials and Methods: In a cross-sectional study we evaluated sexual distress among 88 women who attended the infertility clinic in our institute between January and June 2015. All women who were experiencing primary or secondary infertility during the study sampling were included in the sudy. Sexual distress was measured using the Female sexual distress scale-revised (FSDS-R), a cross-validated patient-reported outcomes measure. Correlations of FSDS-R with patient characteristics and laboratory measurements were calculated using Spearman’s rank correlation tests. Results: With the exceptions of the age of couples and serum anti-mullerian hormone (AMH) levels, no predictor of high sexual distress was found in the univariate analysis when comparing groups with regard to the FSDS-R cut-off score. The mean age of the sexually distressed women (33.6±5.8 years vs. 29.3±5.1 years) and their partners (35.4±4.8 years vs. 31.6±4.2 years) was significantly higher than those of the non distressed women, according to a FSDS-R score over 11 (p<0.05). The serum level of AMH was significantly lower in infertile women with high total sexual distress scores (1.4 vs. 7.6 ng/ mL (p<0.001)). Conclusion: In infertile women, age of woman, age of partner, and serum AMH levels are related with the hope of women to have a child despite an association with sexual distress. Serum AMH, which is perceived as necessary for fertility, had a significant inverse correlation with levels of sexual stress.Publication Open Access Effect of Obesity on Fertility(2015-12-01T00:00:00Z) KARACA, NİLAY; BATMAZ, GONCA; AYDIN, SERDAR; AYDIN, SERDARPrior studies have shown that obesity causes many gynecologic and obstetric disorders, including anovulation, irregular periods, subfertility, abortion, and adverse pregnancy outcomes. Obesityrelated infertility or reduced fertility problems were influenced by any step from follicular recruitment to implantation. Adverse effects in reproductive health were not subjected out of entire obese women. Physical activity and nutrition were shown to be the probable determining factors. Assisted reproductive techniques provide obese women with an opportunity to investigate the relationship with pregestational status and reproductive outcomes as well. Although there is a lack of epidemiological data, an association between obesity and abortion is already known in obese women who had spontaneous pregnancy. This study aimed to investigate the effects of obesity among various stages of the reproductive process in recent studies, to summarize multidisciplinary strategies, and to facilitate reproductive outcomes in obese women.