Person: GÜL, AYŞE ZEHRA
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Publication Metadata only G6PD AND GAPDH AS POTENTIAL DIAGNOSTIC BIOMARKERS FOR IRON DEFICIENCY ANEMIA(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Gül, Ayşe Zehra; Köktaşoğlu, Fatmanur; Sarıkaya, Ufuk; Yıldız, Tuğçe; Dulun Ağaç, Halime; DEMİREL, METİN; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; KÖKTAŞOĞLU, FATMANUR; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DULUN AĞAÇ, HALİMEPublication Metadata only SERUM REFERENCE INTERVALS OF ZINC AND COPPER IN HEALTHY SUBJECTS OF TURKEY POPULATION(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Yıldız, Tuğçe; Sönmez, Rana; Gül, Ayşe Zehra; Sarıkaya, Ufuk; Köktaşoğlu, Fatmanur; DEMİREL, METİN; SELEK, ŞAHABETTİN; YILDIZ, TUĞÇE; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; KÖKTAŞOĞLU, FATMANURPublication Open Access Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease(2023-06-01) Demirel M.; Köktaşoğlu F.; Özkan E.; Dulun Ağaç H.; Gül A. Z.; Sharifov R.; Sarıkaya U.; Başaranoğlu M.; Selek Ş.; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; BAŞARANOĞLU, METİN; SELEK, ŞAHABETTİNObjectives: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of excessive fat in the liver, which can lead to fibrosis and has an increasing prevalence. NAFLD requires non-invasive diagnostic biomarkers. While typically observed in overweight individuals, it can also occur in non-obese/non-overweight individuals. Comparative studies on non-obese NAFLD patients are scarce. This study aimed to conduct a using liquid chromatography-high resolution mass spectrometry (LC-MS/MS)-based metabolic profiling of non-obese NAFLD patients and healthy controls. Materials and methods: The patient group consisted of 27 individuals with NAFLD, while the healthy control group included 39 individuals. Both groups were between 18 and 40 years old, had a BMI of less than 25 and had alcohol consumption less than 20 g/week for men and 10 g/week for women. Serum samples were collected and analyzed using LC-MS/MS. The data were analyzed using the TidyMass and MetaboAnalyst. Results: The LC-MS/MS analyses detected significant changes in D-amino acid metabolism, vitamin B6 metabolism, apoptosis, mTOR signaling pathway, lysine degradation, and phenylalanine metabolism pathways in non-obese NAFLD patients. Significant changes were also observed in the metabolites D-pantothenic acid, hypoxanthine, citric acid, citramalic acid, L-phenylalanine, glutamine, and histamine-trifluoromethyl-toluidide, β-hydroxymyristic acid, DL-Lactic acid, and 3-methyl-2-oxopentanoic. Overall, the study provides valuable insights into the metabolic changes associated with non-obese NAFLD patients and can contribute to the development of non-invasive diagnostic biomarkers for NAFLD.Publication Metadata only Investigation of serum enzyme activities and oxidative stress markers in preeclampsia: a multiparameter analysis(2022-06-01T00:00:00Z) Selek, Şahabettin; Gül, Ayşe Zehra; Atakul, Nil; Meydan, Sedat; Sarıkaya, Alime; Köktaşoğlu, Fatmanur; Atamer, Yıldız; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; MEYDAN, SEDAT; KÖKTAŞOĞLU, FATMANURPublication Metadata only METABOLIC PROFILING STUDY IN SERUM OF PATIENTS WITH POLYCYSTIC KIDNEY DISEASE AND CHRONIC KIDNEYDISEASE BASED ON 1 H NMR SPECTROSCOPY(2021-10-11T00:00:00Z) Köktaşoğlu, Fatmanur; Demirel, Metin; Gül, Ayşe Zehra; Elçioğlu, Ömer Celal; Aris, Özlem; Selek, Şahabettin; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; GÜL, AYŞE ZEHRA; ELÇİOĞLU, ÖMER CELAL; SELEK, ŞAHABETTİNPublication Metadata only Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome(2022-01-01T00:00:00Z) ATAKUL, NİL; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; KILIÇ, BERNA ŞERMİN; GÜL, AYŞE ZEHRA; ATAMER, YILDIZ; SELEK, ŞAHABETTİN; KÖKTAŞOĞLU, FATMANUR; GÜL, AYŞE ZEHRAIntroduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology.Publication Metadata only SERUM METABOLOME ANALYSIS OF IRON DEFICIENCY ANEMIA PATIENTS USING NUCLEAR MAGNETIC RESONANCE(QUANTITATIVE APPROACH)(2021-10-21T00:00:00Z) GÜL, AYŞE ZEHRA; SELEK, ŞAHABETTİN; GÖREN, AHMET CEYHAN; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; SARIKAYA, UFUK; GÜL, AYŞE ZEHRA; SELEK, ŞAHABETTİN; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; SARIKAYA, UFUK