Person: GÜL, AYŞE ZEHRA
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Publication Metadata only G6PD AND GAPDH AS POTENTIAL DIAGNOSTIC BIOMARKERS FOR IRON DEFICIENCY ANEMIA(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Gül, Ayşe Zehra; Köktaşoğlu, Fatmanur; Sarıkaya, Ufuk; Yıldız, Tuğçe; Dulun Ağaç, Halime; DEMİREL, METİN; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; KÖKTAŞOĞLU, FATMANUR; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DULUN AĞAÇ, HALİMEPublication Metadata only SERUM REFERENCE INTERVALS OF ZINC AND COPPER IN HEALTHY SUBJECTS OF TURKEY POPULATION(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Yıldız, Tuğçe; Sönmez, Rana; Gül, Ayşe Zehra; Sarıkaya, Ufuk; Köktaşoğlu, Fatmanur; DEMİREL, METİN; SELEK, ŞAHABETTİN; YILDIZ, TUĞÇE; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; KÖKTAŞOĞLU, FATMANURPublication Open Access Could the PON1 phenotype play a key role in insulin resistance?(2022-06-01T00:00:00Z) Sarikaya, Ufuk; Meydan, Sedat; Selek, Şahabettin; Sarikaya, Alime; Demirel, Metin; Gül, Ayşe Zehra; Yildiz, Tuğçe; SARIKAYA, UFUK; MEYDAN, SEDAT; SELEK, ŞAHABETTİN; DEMİREL, METİN; GÜL, AYŞE ZEHRA; YILDIZ, TUĞÇEAim/objectivesRecent studies have shown that Paraoxonase (PON1) enzyme plays a possible role in insulin synthesis by stimulating insulin release from β-cells of the pancreas as well as its anti-atherosclerotic property. In our study, we revealed the relationship between phenotypes of the PON1 enzyme and insulin resistance (IR) and impaired fasting glucose (IFG).Materials and methodsA cohort of 71 IR, 63 IFG, and 68 healthy individuals was examined in this study. The phenotypic distribution was demonstrated by studying PON1 enzyme’s Paraoxonase (POase) and Arylesterase (AREase) activity with automated measurement kits.ResultsBy measuring the ratio of POase activity to AREase activity, 3 different phenotypes (QQ (Risky or Bad Phenotype), QR (Notre Phenotype), and RR (Good Phenotype)) were discovered. The results showed that IR and IFG individuals had riskier phenotypes compared to the control group. In addition, individuals with bad phenotypes were found to be 1.85 and 2.16 times more likely to get IR and IFG, respectively. Both groups were found to be four times more likely to be affected by the bad phenotype (odds ratio: 3.69 and 4.47 respectively).ConclusionIn this present study, the relationship between PON1 enzyme phenotypes and IR was evaluated for the first time in this field. Decreased PON1 activity and poor phenotype may also increase the development of hyperglycemia or diabetes mellitus (DM) due to IR and IFG. It may also predispose to diseases such as atherosclerosis. Therefore, we think that further investigations to explain the possible mechanisms underlying the relationship between PON1 phenotypes, IR and IFG will be useful in the early diagnosis and prevention ofprediabetes.Publication Open Access Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease(2023-06-01) Demirel M.; Köktaşoğlu F.; Özkan E.; Dulun Ağaç H.; Gül A. Z.; Sharifov R.; Sarıkaya U.; Başaranoğlu M.; Selek Ş.; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; BAŞARANOĞLU, METİN; SELEK, ŞAHABETTİNObjectives: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of excessive fat in the liver, which can lead to fibrosis and has an increasing prevalence. NAFLD requires non-invasive diagnostic biomarkers. While typically observed in overweight individuals, it can also occur in non-obese/non-overweight individuals. Comparative studies on non-obese NAFLD patients are scarce. This study aimed to conduct a using liquid chromatography-high resolution mass spectrometry (LC-MS/MS)-based metabolic profiling of non-obese NAFLD patients and healthy controls. Materials and methods: The patient group consisted of 27 individuals with NAFLD, while the healthy control group included 39 individuals. Both groups were between 18 and 40 years old, had a BMI of less than 25 and had alcohol consumption less than 20 g/week for men and 10 g/week for women. Serum samples were collected and analyzed using LC-MS/MS. The data were analyzed using the TidyMass and MetaboAnalyst. Results: The LC-MS/MS analyses detected significant changes in D-amino acid metabolism, vitamin B6 metabolism, apoptosis, mTOR signaling pathway, lysine degradation, and phenylalanine metabolism pathways in non-obese NAFLD patients. Significant changes were also observed in the metabolites D-pantothenic acid, hypoxanthine, citric acid, citramalic acid, L-phenylalanine, glutamine, and histamine-trifluoromethyl-toluidide, β-hydroxymyristic acid, DL-Lactic acid, and 3-methyl-2-oxopentanoic. Overall, the study provides valuable insights into the metabolic changes associated with non-obese NAFLD patients and can contribute to the development of non-invasive diagnostic biomarkers for NAFLD.Publication Metadata only Investigation of serum enzyme activities and oxidative stress markers in preeclampsia: a multiparameter analysis(2022-06-01T00:00:00Z) Selek, Şahabettin; Gül, Ayşe Zehra; Atakul, Nil; Meydan, Sedat; Sarıkaya, Alime; Köktaşoğlu, Fatmanur; Atamer, Yıldız; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; MEYDAN, SEDAT; KÖKTAŞOĞLU, FATMANURPublication Metadata only Examining the oxidative status in peripheral bloods of schizophrenia patients and first degree relatives(2019-07-04T00:00:00Z) GÜL, AYŞE ZEHRA; GÜLER, ERAY METİN; GÜL, AYŞE ZEHRAPublication Metadata only The Importance of Postpartum Kleihauer-Betke Test in Low Risk Rh-Incompatible Pregnant Population(2021-04-01T00:00:00Z) Bilgili, Ümmühan Zeynep; Gül, Ayşe Zehra; Kütük, Mehmet Serdar; GÜL, AYŞE ZEHRA; KÜTÜK, MEHMET SERDARIntroduction: Prevalence of Rh disease is estimated to be 276 per 100,000 live births, which is significant considering its relationship with conditions like fetal anemia, hydrops fetalis, fetal death and recurrent fetal demises in future pregnancies. In order to prevent these, anti-D immunoglobulin should be given after inciting events, in a dose sufficient. In Turkey and some other countries, anti-D dose is given on -one shot fits for all- principle. Here, we challenge the conventional wisdom and evaluate the amount of fetomaternal hemorrhage (FMH) and adjusted the dose of anti-D accordingly. Method: In our study, Rh incompatible women who gave birth between October 2020 and March 2021 were included. FMH was determined by the Kleihauer-Betke test in the blood sample taken from the mothers after delivery. Blood smears were fixed with ethyl alcohol and incubated in citric acid buffer solution. In acid medium, HbF becomes resistant to elution, while other types are removed from erythrocytes. The smears are then taken under a microscope to examine the percentage of cells containing fetal hemoglobin. We used Oski-Naiman method to count fetal cells present, then estimated FMH using Mollison-s formula. Clinical data were available at hospital-s digital system. Results: Seventy patients got tested during study period. Twenty-five (39.6%) of cases had more than 4 mL of FMH. Among them, one (1.6%) case was found to have more than 30 mL of FMH, and was given an additional dose. This case had no obstetrical risk factor such as antepartum bleeding, preeclampsia, or manual removal of placenta. The rate of smoking was significantly higher in cases with more than 4 mL of FMH (p=0.001). There were no other variables differed significantly in women having more than 4 mL of FMH. Conclusion: FMH requiring more than 300 mcg of anti-D is significantly high in low-risk pregnant women in Turkey. Implementation of quantitative FMH testing with Kleihauer-Betke or flow cytometry test is necessary. Key words: Fetomaternal hemorrhage, Rh incompatibilityPublication Metadata only Copper (II) increases anti-proliferative activity of thymoquinone in colon cancer cells by increasing genotoxic, apoptotic and reactive oxygen species generating effects.(2019-10-15T00:00:00Z) Yenigün, Vildan Betül; Gül, Ayşe Zehra; YENİGÜN, VILDAN BETÜL; GÜL, AYŞE ZEHRAPublication Unknown METABOLIC PROFILING STUDY IN SERUM OF PATIENTS WITH POLYCYSTIC KIDNEY DISEASE AND CHRONIC KIDNEYDISEASE BASED ON 1 H NMR SPECTROSCOPY(2021-10-11T00:00:00Z) Köktaşoğlu, Fatmanur; Demirel, Metin; Gül, Ayşe Zehra; Elçioğlu, Ömer Celal; Aris, Özlem; Selek, Şahabettin; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; GÜL, AYŞE ZEHRA; ELÇİOĞLU, ÖMER CELAL; SELEK, ŞAHABETTİNPublication Unknown Examining the oxidative status in peripheral bloods of schizophrenia patients and first degree relatives(2019-07-01T00:00:00Z) Gul, AYŞE ZEHRA; Metin, G. Eray; GÜL, AYŞE ZEHRA