Person: GÜL, AYŞE ZEHRA
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Publication G6PD AND GAPDH AS POTENTIAL DIAGNOSTIC BIOMARKERS FOR IRON DEFICIENCY ANEMIA(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Gül, Ayşe Zehra; Köktaşoğlu, Fatmanur; Sarıkaya, Ufuk; Yıldız, Tuğçe; Dulun Ağaç, Halime; DEMİREL, METİN; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; KÖKTAŞOĞLU, FATMANUR; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DULUN AĞAÇ, HALİMEPublication SERUM REFERENCE INTERVALS OF ZINC AND COPPER IN HEALTHY SUBJECTS OF TURKEY POPULATION(2021-10-21T00:00:00Z) Demirel, Metin; Selek, Şahabettin; Yıldız, Tuğçe; Sönmez, Rana; Gül, Ayşe Zehra; Sarıkaya, Ufuk; Köktaşoğlu, Fatmanur; DEMİREL, METİN; SELEK, ŞAHABETTİN; YILDIZ, TUĞÇE; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; KÖKTAŞOĞLU, FATMANURPublication Could the PON1 phenotype play a key role in insulin resistance?(2022-06-01T00:00:00Z) Sarikaya, Ufuk; Meydan, Sedat; Selek, Şahabettin; Sarikaya, Alime; Demirel, Metin; Gül, Ayşe Zehra; Yildiz, Tuğçe; SARIKAYA, UFUK; MEYDAN, SEDAT; SELEK, ŞAHABETTİN; DEMİREL, METİN; GÜL, AYŞE ZEHRA; YILDIZ, TUĞÇEAim/objectivesRecent studies have shown that Paraoxonase (PON1) enzyme plays a possible role in insulin synthesis by stimulating insulin release from β-cells of the pancreas as well as its anti-atherosclerotic property. In our study, we revealed the relationship between phenotypes of the PON1 enzyme and insulin resistance (IR) and impaired fasting glucose (IFG).Materials and methodsA cohort of 71 IR, 63 IFG, and 68 healthy individuals was examined in this study. The phenotypic distribution was demonstrated by studying PON1 enzyme’s Paraoxonase (POase) and Arylesterase (AREase) activity with automated measurement kits.ResultsBy measuring the ratio of POase activity to AREase activity, 3 different phenotypes (QQ (Risky or Bad Phenotype), QR (Notre Phenotype), and RR (Good Phenotype)) were discovered. The results showed that IR and IFG individuals had riskier phenotypes compared to the control group. In addition, individuals with bad phenotypes were found to be 1.85 and 2.16 times more likely to get IR and IFG, respectively. Both groups were found to be four times more likely to be affected by the bad phenotype (odds ratio: 3.69 and 4.47 respectively).ConclusionIn this present study, the relationship between PON1 enzyme phenotypes and IR was evaluated for the first time in this field. Decreased PON1 activity and poor phenotype may also increase the development of hyperglycemia or diabetes mellitus (DM) due to IR and IFG. It may also predispose to diseases such as atherosclerosis. Therefore, we think that further investigations to explain the possible mechanisms underlying the relationship between PON1 phenotypes, IR and IFG will be useful in the early diagnosis and prevention ofprediabetes.Publication Fumaraz enziminin Shewanella putrefaciens bakterisinden üretimi ve biyokimyasal tanı kitlerinde kullanılması(2021-10-31T00:00:00Z) Toruntay, Ceyhun; Korkmaz, Nur Damla; Selek, Şahabettin; Gül, Ayşe Zehra; Demirel, Metin; Sarıkaya, Ufuk; Akbaş, Fahri; TORUNTAY, CEYHUN; KORKMAZ, NUR DAMLA; SELEK, ŞAHABETTİN; GÜL, AYŞE ZEHRA; DEMİREL, METİN; AKBAŞ, FAHRİPublication Maternal Serum Levels of Zinc, Copper, and Thiols in Preeclampsia Patients: a Case-Control Study.(2021-03-11T00:00:00Z) Gul, Ayse Zehra; Atakul, Nil; Selek, ŞAHBETTİN; Sarıkaya, Ufuk; Yıldız, Tugce; Demirel, Metin; GÜL, AYŞE ZEHRA; SELEK, ŞAHABETTİN; SARIKAYA, UFUK; YILDIZ, TUĞÇE; DEMİREL, METİNPublication Examining the oxidative status in peripheral bloods of schizophrenia patients and first degree relatives(2019-07-11T00:00:00Z) GÜL, AYŞE ZEHRA; GÜLER, ERAY METİN; GÜL, AYŞE ZEHRA; GÜLER, ERAY METİNPublication KRONİK ENFLAMASYON Moleküler Patofizyoloji, Beslenme ve Terapötik Girişimler(2019-01-01T00:00:00Z) GÜL, AYŞE ZEHRA; KOÇYİĞİT, ABDÜRRAHİM; GÜL, AYŞE ZEHRA; KOÇYİĞİT, ABDÜRRAHİMPublication Oxidative stress and schizophrenia: A comparative cross-sectional study of multiple oxidative markers in patients and their first-degree relatives.(2021-08-09T00:00:00Z) Guler, Eray Metin; Kurtulmus, Ayse; Gul, AYŞE ZEHRA; Kirpinar, Ismet; GÜL, AYŞE ZEHRA; KOÇYİĞİT, ABDÜRRAHİMPublication TEMEL MİTOKONDRİYAL TIP(2021-01-01T00:00:00Z) GÜL, AYŞE ZEHRA; KOÇYİĞİT, ABDÜRRAHİM; GÜL, AYŞE ZEHRA; KOÇYİĞİT, ABDÜRRAHİMPublication Examining the oxidative status in peripheral bloods of schizophrenia patients and first degree relatives(2019-07-04T00:00:00Z) GÜL, AYŞE ZEHRA; GÜLER, ERAY METİN; GÜL, AYŞE ZEHRA