Person: ÇETİN, GÜVEN
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Publication A Rare Skin Lesion Seen in Acute Myeloid Leukemia: Skin Infiltration(2013-06-01T00:00:00Z) ÇETİN, GÜVEN; AR, Muhlis Cem; Borku, Betul; Cerit, Abdullah; Gozubenli, Kubra; ÇETİN, GÜVEN80% of leukemias in adults present as the acute myeloid leukemia (AML) form. Many different types of skin lesion can be seen in the course of leukemias. Most of them are benign lesions resulting from chemotherapeutic drug reactions, infectious complications due to immunosuppression, cytopenias or hemorrhagic diathesis. Leukemia cutis (LC) are rare lesions of the skin showing infiltration of malignant cells. The diagnosis of LC is often made with or after the diagnosis of systemic leukemia. In this study we discuss a patient who was admitted to the emergency department because of skin rashes and was diagnosed with AML. LC was detected in this patient after a follow-up biopsy of skin lesions.Publication Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin-s or Non-Hodgkin-s Lymphoma?(2015-09-01) ÇETIN, GÜVEN; ÖZKAN, T; AR, MC; EŞKAZAN, AE; AYER, M; CERIT, A; ÇIKRIKÇIOĞLU, MA; GÖZÜBENLI, K; Karatoprak, CUMALİ; UYSAL, BB; ERDEM, S; ERGÜL, N; TATAR, G; ÇERMIK, TF; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ERDEM, ŞÜKRANObjective: Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of lymphoma. We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in patients with Hodgkin's lymphoma (HL) and aggressive non-Hodgkin's lymphoma (aNHL). Materials and Methods: The medical files of a total of 297 patients diagnosed with HL or aNHL and followed at the hematology clinics of 3 major hospitals in Istanbul between 2008 and 2012 were screened retrospectively and 161 patients with classical HL and aNHL were included in the study. The patients were referred for PET/CT and BMB at the initial staging. BMB was performed as the reference standard for the evaluation of BMI. Results: There were 61 (38%) HL and 100 (62%) aNHL patients. Concordant results were revealed between PET/CT and BMB in 126 patients (78%) (52 HL, 74 aNHL), 20 with positive PET/CT and BMB results and 106 with negative PET/CT and BMB results. There were discordant results in 35 patients (9 HL, 26 aNHL), 16 of them with positive BMB and negative PET/CT results and 19 of them with negative BMB and positive PET/CT results. Conclusion: We observed that PET/CT is effective to detect BMI, despite it alone not being sufficient to evaluate BMI in HL and aNHL. Bone marrow trephine biopsy and PET/CT should be considered as mutually complementary methods for detection of BMI in patients with lymphoma. In suspected focal involvement, combining biopsy and PET/CT might improve staging results.Publication Association of calcium channel blocker use with lower hemoglobin levels in chronic kidney disease(2013-09-01) Karatoprak, CUMALİ; CIKRIKCIOGLU, M. A.; Cakirca, MUSTAFA; Kiskac, MUHARREM; Zorlu, MEHMET; Cetin, GÜVEN; YILDIZ, KEMALETTİN; ERKOC, R.; ALAY, M.; Erkal, S.; Erkal, S. N.; DOGAN, S.; Kazancioglu, RÜMEYZA; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇETİN, GÜVEN; YILDIZ, KEMALETTİN; KAZANCIOĞLU, RÜMEYZAAim: To search whether calcium channel blockers (CCBs) are associated with lower hemoglobin levels in chronic kidney disease (CKD) patients who are not on renal replacement therapy (RRT), vitamin D and anti-anemic treatment. Patients and methods: CKD patients were classified into two groups. Patients on CCBs treatment (103 patients) and patients not using CCBs (104 patients) were compared cross-sectionally regarding clinical findings, complete blood count (CBC), biochemistry and regular medication use. Patients with polycystic kidney disease, comorbidities that could influence CBC other than iron deficiency of obscure origin, patients receiving RRT, erythropoietin (EPO), vitamin D, phosphate binders and drugs that could influence CBC were excluded. Under dependent variable of CCB use, all significantly different independent variables were subjected to multivariate binary logistic regression analysis (MBLRA). Results: Lower hemoglobin, lower bilirubinemia, higher serum EPO, higher systolic blood pressure were observed in CCB users. Two groups were similar concerning age, gender, BMI, CKD etiology, CKD stage, pretibial edema prevalence, cardiothoracic index, diastolic blood pressure, corrected reticulocyte count, BUN, creatinine, eGFR, proBNP, parathormone, alkaline phosphatase, phosphorous, corrected calcemia, sCRP, relative EPO deficiency and prevalence of relative EPO deficient patients. Groups were comparable regarding comorbidities, types and usage frequencies of all antihypertensive medications other than CCBs. Higher systolic blood pressure and lower hemoglobin were significantly associated with CCB use after MBLRA. Conclusions: Hemoglobin was significantly lower in CCB users compared to non-users, among CKD patients who did not receive RRT, EPO, phosphate binders, vitamin D, iron, vitamin B12 and folic acid.Publication A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience(2019-01-01T00:00:00Z) Esen, Ramazan; Cekdemir, Demet; Guvenc, Serkan; Ozdemirkiran, Fusun; Eser, Ali; Topts, Tayfur; ÖZKOCAMAN, VİLDAN; ŞAHİN, HANDAN HAYDAROĞLU; ERMİŞ TURAK, Esra; Comert, Melda; Sadrilo, Sevil; Aslaner, Muzeyyen; Ulu, Bahar Uncu; KARAKUŞ, ABDULLAH; Bapur, Derya Selim; ALACACIOĞLU, İNCİ; Aydin, Demet; Tekinalp, Atakan; Namdaroglu, Sinem; Ceran, Funda; TARKUN, PINAR; Kiper, Demet; Cetiner, Mustafa; Yenerel, Mustafa; DEMİR, AHMET MUZAFFER; Yilmaz, Guven; TERZİ, HATİCE; Atilla, Erden; Malkan, Umit Yavuz; Acar, Kadir; Ozturk, Erman; TOMBAK, ANIL; Sunu, Cenk; SALİM, OZAN; Alayvaz, Nevin; Sayan, Ozkan; Ozan, Ulku; Ayer, Mesut; Gokgoz, Zafer; ANDIÇ, NESLİHAN; Kizilkilic, Ebru; Noyan, Figen; Ozen, Mehmet; Tanrikulu, Funda Pepedil; Alanoglu, Guchan; Ozkan, Hasan Atilla; Aslan, Vahap; ÇETİN, GÜVEN; Erikci, Alev Akyol; Deveci, Burak; Dursun, Fadime Ersoy; Dermenci, Hasan; Aytan, Pelin; Gunduz, Mehmet; Karakus, Volkan; Ozlu, Can; Demircioğlu, Sinan; Yanar, Olga Meltem Akay; ÖZATLI, DÜZGÜN; ÜNDAR, LEVENT; TİFTİK, EYÜP NACİ; Sucak, EAyhan Gulsan Turkoz; Haznedaroglu, Ibrahim; ÖZCAN, MUHİT; ŞENCAN, MEHMET; TOMBULOĞLU, MURAT; Ozet, Gulsum; Bilgir, Oktay; TURGUT, BURHAN; ÖZCAN, MEHMET ALİ; Payzin, Kadriye Bahriye; SÖNMEZ, MEHMET; Ayyildiz, EOrhan; Dal, Mehmet Sinan; Ertop, Sehmus; Turgut, Mehmet; Soysal, Teoman; KAYA, EMİN; ÜNAL, ALİ; PEHLİVAN, MUSTAFA; ATAGÜNDÜZ, IŞIK; Firatli, Tulin Tuglular; SAYDAM, GÜRAY; Kucukkaya, Reyhan Diz; ÇETİN, GÜVENObjective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP).Publication Optimisation of Centrifugal Speed for PRPBAG (R): A Novel Multiple Bag System for Preparing Platelet-Rich Plasma(2021-07-01T00:00:00Z) ÇETİN, GÜVEN; KYIO, NANG HSENG; Turgut, Seda; ÖZKAN TEKİN, Tuba; ÇETİN, GÜVEN; KYIO, NANG HSENGObjective: This study aimed to identify the optimal centrifugal speed for the preparation of platelet-rich plasma (PRP) with PRPBAG (R), a novel multi-bag system. Methods: The study included 120 (60 women and 60 men) clinically healthy volunteers aged 18-35 years. Participants were divided into three age-sex matched groups according to the centrifugation speeds as follows: 1600 rpm (n=40), 1800 rpm (n=40) or 2000 rpm (n=40). Whole blood (150 mL) was drawn from the volunteers, and centrifugation was performed for 10 minutes. After the first spin, the erythrocytes precipitated in the first bag, and the supernatant plasma was transferred into the second bag. Plasma centrifugation was performed at 3500 rpm for 15 minutes. The high-quality PRP product precipitated in the second bag. The supernatant plateletpoor plasma was transferred to the third bag and destroyed. Blood cell count of whole blood and PRP product was measured. Results: The mean white blood cell level of PRP in the 1800 rpm group was higher than the other groups (p=0.027). The mean platelet levels were 1005.22 +/- 105.96, 1743.7 +/- 145.2 and 1743.7 +/- 145.2 103/uL in the 1600, 1800 and 2000 rpm groups, respectively, after centrifugation (p<0.001). Accordingly, the platelet yield (fold increase) was significantly greater in the 1800 rpm group than in the other groups (p<0.001). Conclusion: This study showed that 1800 rpm for 10 minutes is the optimum first centrifugation speed for preparing PRP with PRPBAG (R), as it provides an approximately eightfold increase in platelet concentration in PRPBAG (R)Publication Evaluation of clinical and laboratory findings with JAK2 V617F mutation as an independent variable in essential thrombocytosis.(2014-10-01) Cetin, GÜVEN; OZKAN, T; TURGUT, SEDA; Ali, Cikrikcioglu; CEM, AR M; AYER, M; UNLU, A; KARATOPRAK, CUMALİ; SEKIN, Y; ÇETİN, GÜVEN; TURGUT, SEDA; ÇELİK, ŞENGÜL; KARATOPRAK, CUMALİPublication An Iron Deficiency Anemia Case That Came with Raw Rice Consumption(2015-02-01) ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMET; ALAY, MURAT; ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMETPica is the chronic consumption of edible or nonedible materials that is thought to be caused by mental problems, pregnancy, or anemia. We wanted to report this case, which we have not seen in the literature before, of a pica patient who consumed raw rice due to iron deficiency anemia. A 26-year-old female patient was brought to the internal medicine polyclinic by her mother with complaints of consuming a bowl of raw rice (200 gr) every evening. The patient was treated with parenteral ferik hydroxide + sucrose complex (2700 mg) for 5 days. After 15 days, when she came to control her will to eat raw rice had been lost completely. As a result, the attention of doctors and family members for pica due to treatable causes, such as anemia, will prevent many probable complications.Publication Bezmialem Vakıf Üniversitesi Tıp Fakültesi Hastanesi Transfüzyon Merkezinde 2012-2013 yılları arasında bağışçı kanlarındaki kan grupları dağılımı(2013-11-27T00:00:00Z) Yüksel Salduz, Zeyneb İrem; Çetin, Güven; Özkan Tekin, Tuba; Yasin, Ayşe İrem; Yüce, Seda; Çınar, Ahmet; ÇETİN, GÜVEN; YASİN, AYŞE İREMPublication Real Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T Cell Lymphomas: A Multicenter Study of Turkish Hematology Research and Education Group (Threg).(2022-06-09T00:00:00Z) Kayıkçı, Ömür; Mehtap, Özgür; Sarı, İsmail; Demirkan, Fatih; Beyan, Cengiz; Çetin, GÜVEN; Vural, Filiz; Yılmaz, Mehmet; Öztürk, Erman; Akpınar, Seval; Eser, Bülent; Gündüz, Mehmet; Büyükaşık, Yahya; Payzın, Bahriye; Yıldırım, Rahşan; Doğu, Mehmet Hilmi; Özkan, Atilla; Kelkitli, Engin; Tekgündüz, Emre; ÇETİN, GÜVENPublication ABO and Rh Blood Group Distribution in Istanbul Province(2015-01-01T00:00:00Z) SALDUZ, ZEYNEB IREM YUKSEL; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLAN; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLAN