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ÇETİN, GÜVEN

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GÜVEN
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ÇETİN
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Now showing 1 - 10 of 57
  • PublicationOpen Access
    CD40 ligand and P-selectin in heterozygous Beta-thalassemia
    (2016-06-01) CIKRIKCIOGLU, Mehmet Ali; SOYTAS, Rabia Bag; KILIC, Elif; Toprak, Aybala Erek; Karatoprak, CUMALİ; Zorlu, MEHMET; Kiskac, MUHARREM; EMEGIL, Sebnem; Cetin, GÜVEN; Dogan, ELİF ECE; SEKIN, Yahya; HAMDARD, Jamshid; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; KISKAÇ, MUHARREM; ÇETİN, GÜVEN; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİ
    Objective: To investigate platelet functions and measure soluble CD40 ligand, soluble P-selectin, beta-thromboglobulin and platelet factor 4 levels in the blood of heterozygous beta thalassemia patients. Methods: The cross-sectional case-control study was conducted at Bezmialem Vakif University, Istanbul, Turkey, between September 2013 and April 2014, and comprised heterozygous beta thalassemia patients who were compared with 41 gender-, age- and body mass index-matched controls for platelet function markers. The two groups were also compared for co-morbidities, smoking, and regular medications. Results: Of the 78(78.78) subjects, 50(64%) were women and 28(36%) men with an overall mean age of 39.4±12.7 years (range: 18-79 years). The mean body mass index was 26.3±4.2. The heterozygous beta thalassemia group included 37(47%) subjects [24(65%) females; 13(35%) males] while the control group had 41(53%) [26(63%) females; 15(37%) males]. Soluble CD40 ligand and soluble P-selectin were lower in the heterozygous beta thalassemia group (p=0.009; p=0.010). Beta-thromboglobulin and platelet factor 4 levels were comparable between the groups (p=0.497; p=0.507.). Conclusions: Some platelet functions may be reduced in heterozygous beta thalassemia patients, which may be related to their lower incidence of cerebral and cardiac ischaemic events.
  • PublicationMetadata only
    Yeni Açılan Aferez Merkezinin Altı Aylık deneyimi
    (2013-09-05T00:00:00Z) Çetin, Güven; Yüksel Salduz, Zeyneb İrem; Özkan Tekin, Tuba; Yüce, Seda; Emeklioğlu, Sami; ÇETİN, GÜVEN; YÜKSEL SALDUZ, ZEYNEB İREM
  • PublicationOpen Access
    Association of calcium channel blocker use with lower hemoglobin levels in chronic kidney disease
    (2013-09-01) Karatoprak, CUMALİ; CIKRIKCIOGLU, M. A.; Cakirca, MUSTAFA; Kiskac, MUHARREM; Zorlu, MEHMET; Cetin, GÜVEN; YILDIZ, KEMALETTİN; ERKOC, R.; ALAY, M.; Erkal, S.; Erkal, S. N.; DOGAN, S.; Kazancioglu, RÜMEYZA; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇETİN, GÜVEN; YILDIZ, KEMALETTİN; KAZANCIOĞLU, RÜMEYZA
    Aim: To search whether calcium channel blockers (CCBs) are associated with lower hemoglobin levels in chronic kidney disease (CKD) patients who are not on renal replacement therapy (RRT), vitamin D and anti-anemic treatment. Patients and methods: CKD patients were classified into two groups. Patients on CCBs treatment (103 patients) and patients not using CCBs (104 patients) were compared cross-sectionally regarding clinical findings, complete blood count (CBC), biochemistry and regular medication use. Patients with polycystic kidney disease, comorbidities that could influence CBC other than iron deficiency of obscure origin, patients receiving RRT, erythropoietin (EPO), vitamin D, phosphate binders and drugs that could influence CBC were excluded. Under dependent variable of CCB use, all significantly different independent variables were subjected to multivariate binary logistic regression analysis (MBLRA). Results: Lower hemoglobin, lower bilirubinemia, higher serum EPO, higher systolic blood pressure were observed in CCB users. Two groups were similar concerning age, gender, BMI, CKD etiology, CKD stage, pretibial edema prevalence, cardiothoracic index, diastolic blood pressure, corrected reticulocyte count, BUN, creatinine, eGFR, proBNP, parathormone, alkaline phosphatase, phosphorous, corrected calcemia, sCRP, relative EPO deficiency and prevalence of relative EPO deficient patients. Groups were comparable regarding comorbidities, types and usage frequencies of all antihypertensive medications other than CCBs. Higher systolic blood pressure and lower hemoglobin were significantly associated with CCB use after MBLRA. Conclusions: Hemoglobin was significantly lower in CCB users compared to non-users, among CKD patients who did not receive RRT, EPO, phosphate binders, vitamin D, iron, vitamin B12 and folic acid.
  • PublicationMetadata only
    A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience
    (2019-01-01T00:00:00Z) Esen, Ramazan; Cekdemir, Demet; Guvenc, Serkan; Ozdemirkiran, Fusun; Eser, Ali; Topts, Tayfur; ÖZKOCAMAN, VİLDAN; ŞAHİN, HANDAN HAYDAROĞLU; ERMİŞ TURAK, Esra; Comert, Melda; Sadrilo, Sevil; Aslaner, Muzeyyen; Ulu, Bahar Uncu; KARAKUŞ, ABDULLAH; Bapur, Derya Selim; ALACACIOĞLU, İNCİ; Aydin, Demet; Tekinalp, Atakan; Namdaroglu, Sinem; Ceran, Funda; TARKUN, PINAR; Kiper, Demet; Cetiner, Mustafa; Yenerel, Mustafa; DEMİR, AHMET MUZAFFER; Yilmaz, Guven; TERZİ, HATİCE; Atilla, Erden; Malkan, Umit Yavuz; Acar, Kadir; Ozturk, Erman; TOMBAK, ANIL; Sunu, Cenk; SALİM, OZAN; Alayvaz, Nevin; Sayan, Ozkan; Ozan, Ulku; Ayer, Mesut; Gokgoz, Zafer; ANDIÇ, NESLİHAN; Kizilkilic, Ebru; Noyan, Figen; Ozen, Mehmet; Tanrikulu, Funda Pepedil; Alanoglu, Guchan; Ozkan, Hasan Atilla; Aslan, Vahap; ÇETİN, GÜVEN; Erikci, Alev Akyol; Deveci, Burak; Dursun, Fadime Ersoy; Dermenci, Hasan; Aytan, Pelin; Gunduz, Mehmet; Karakus, Volkan; Ozlu, Can; Demircioğlu, Sinan; Yanar, Olga Meltem Akay; ÖZATLI, DÜZGÜN; ÜNDAR, LEVENT; TİFTİK, EYÜP NACİ; Sucak, EAyhan Gulsan Turkoz; Haznedaroglu, Ibrahim; ÖZCAN, MUHİT; ŞENCAN, MEHMET; TOMBULOĞLU, MURAT; Ozet, Gulsum; Bilgir, Oktay; TURGUT, BURHAN; ÖZCAN, MEHMET ALİ; Payzin, Kadriye Bahriye; SÖNMEZ, MEHMET; Ayyildiz, EOrhan; Dal, Mehmet Sinan; Ertop, Sehmus; Turgut, Mehmet; Soysal, Teoman; KAYA, EMİN; ÜNAL, ALİ; PEHLİVAN, MUSTAFA; ATAGÜNDÜZ, IŞIK; Firatli, Tulin Tuglular; SAYDAM, GÜRAY; Kucukkaya, Reyhan Diz; ÇETİN, GÜVEN
    Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP).
  • PublicationMetadata only
    A Rare Skin Lesion Seen in Acute Myeloid Leukemia: Skin Infiltration
    (2013-06-01T00:00:00Z) ÇETİN, GÜVEN; AR, Muhlis Cem; Borku, Betul; Cerit, Abdullah; Gozubenli, Kubra; ÇETİN, GÜVEN
    80% of leukemias in adults present as the acute myeloid leukemia (AML) form. Many different types of skin lesion can be seen in the course of leukemias. Most of them are benign lesions resulting from chemotherapeutic drug reactions, infectious complications due to immunosuppression, cytopenias or hemorrhagic diathesis. Leukemia cutis (LC) are rare lesions of the skin showing infiltration of malignant cells. The diagnosis of LC is often made with or after the diagnosis of systemic leukemia. In this study we discuss a patient who was admitted to the emergency department because of skin rashes and was diagnosed with AML. LC was detected in this patient after a follow-up biopsy of skin lesions.
  • PublicationOpen Access
    An Iron Deficiency Anemia Case That Came with Raw Rice Consumption
    (2015-02-01) ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMET; ALAY, MURAT; ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMET
    Pica is the chronic consumption of edible or nonedible materials that is thought to be caused by mental problems, pregnancy, or anemia. We wanted to report this case, which we have not seen in the literature before, of a pica patient who consumed raw rice due to iron deficiency anemia. A 26-year-old female patient was brought to the internal medicine polyclinic by her mother with complaints of consuming a bowl of raw rice (200 gr) every evening. The patient was treated with parenteral ferik hydroxide + sucrose complex (2700 mg) for 5 days. After 15 days, when she came to control her will to eat raw rice had been lost completely. As a result, the attention of doctors and family members for pica due to treatable causes, such as anemia, will prevent many probable complications.
  • PublicationMetadata only
    Bezmialem Vakıf Üniversitesi Tıp Fakültesi Hastanesi Transfüzyon Merkezinde 2012-2013 yılları arasında bağışçı kanlarındaki kan grupları dağılımı
    (2013-11-27T00:00:00Z) Yüksel Salduz, Zeyneb İrem; Çetin, Güven; Özkan Tekin, Tuba; Yasin, Ayşe İrem; Yüce, Seda; Çınar, Ahmet; ÇETİN, GÜVEN; YASİN, AYŞE İREM
  • PublicationMetadata only
    Tekrarlayan piyüri ile gelen ve ailevi akdeniz ateşi tanısı konulan olgu sunumu
    (2014-10-19) KARATOPRAK, CUMALİ; ERKOÇ, REHA; ÇIKRIKÇIOĞLU, MEHMET ALİ; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; ÇETİN, GÜVEN; KAZANCIOĞLU, RUMEYZA; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; ÇETİN, GÜVEN
  • PublicationMetadata only
    Preparation and characterization of amine functional nano-hydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications
    (2017-05-01T00:00:00Z) Atak, Besir Hakan; Buyuk, Berna; Huysal, Merve; Isik, Sevim; Senel, Mehmet; Metzger, Wolfgang; ÇETİN, GÜVEN; ÇETİN, GÜVEN
    In this study, three different types of scaffolds including a uniquely modified composite scaffold - namely chitosan (CTS), nano-hydroxyapatite/chitosan composite (CTS + nHAP), and amine group (NH2) modified nano-hydroxyapatite/chitosan composite (CTS + nHAP-NH2) scaffolds- were synthesized for bone tissue engineering (BTE) purposes. As results of the study, it was found that all scaffold types were biodegradable with CTS and CTS + nHAP scaffolds losing up to 15% of their initial weight, while the CTS + nHAP-NH2 scaffold showing 10% of weight loss after six weeks of lysozyme treatment. In addition, all three types of scaffolds were shown to be biocompatible, and amongst them CTS + nHAP-NH2 scaffolds supported the most cell proliferation in WST-1 assay and expressed the least and acceptable level of cytotoxicity in lactate dehydrogenase (LDH) test for human bone mesenchymal stem cells (hBM-MSCs). Finally, during osteoinductivity assessment, CTS + nHAP-NH2 nearly tripled initial alkaline phosphatase (ALP) activity when whereas both CTS and CTS + nHAP scaffolds only doubled. These results indicate that all synthesized scaffold types under investigation have certain potential to be used in bone tissue engineering approaches with CTS + nHAP-NH2 scaffold being the most promising and applicable one. In the future, we plan to intensify our studies on osteogenic differentiation on our scaffolds on a detailed molecular level and to include in vivo studies for pre-clinical purposes. (C) 2017 Elsevier Ltd. All rights reserved.
  • PublicationMetadata only
    DEMOGRAPHIC EVALUATION OF ATTEMPTED SUICIDE BY DRUG OVERDOSE IN ISTANBUL
    (2015-01-01) Karatoprak, CUMALİ; KARABULUT, Laika; KAYA, Bilgivar; ALTINDAL, Mahmut; UGURLUKISI, Bilal; KILICASLAN, Mehmet Hanifi; ABANONU, Gul Babacan; Cetin, GÜVEN; CIKRIKCIOGLU, Mehmet Ali; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN
    Introduction: In recent years in our country, as well as all over the world, the frequency of attempted suicide by drug overdose is very noticeable. In our study, we aimed to identify general characteristics of patients with drug-attempted suicide, their drug preferences, and the ways in which they obtained the drugs. We conducted an observational study of patients who came to the emergency department with an indication of drug use for attempted suicide during the one-year.