Person: KARATOPRAK, CUMALİ
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Publication Open Access Assessment of serum endocan levels in patients with beta-thalassemia minor(2022-02-01T00:00:00Z) Zorlu, Mehmet; Ozer, Ömer Faruk; Karatoprak, Cumali; Kıskaç, Muharrem; Çakırca, Mustafa; ZORLU, MEHMET; ÖZER, ÖMER FARUK; KARATOPRAK, CUMALİObjective: Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organs. Our aim was to investigate the relationship between the beta-thalassemia minor patients and the healthy control group in terms of serum endocan level. Methods: The study was performed in a total of 80 subjects. They were divided into two groups, the beta-thalassemia minor group (n=40) and the healthy control group (n=40). Serum endocan levels, age, sex, body mass index value, and tobacco use data of these groups were compared. Results: No statistically significant difference was detected between the two groups in terms of age, sex, and body mass index values (p>0.05). Endocan levels were measured to be 206.85±88.1 pg/mL in the beta-thalassemia minor group and 236.1±162.8 pg/mL in the control group with no significant difference between the groups in terms of serum endocan levels (p>0.05). Conclusions: In our study, there was no change in endocan level in beta-thalassemia minor. This might be because serum endocan levels are affected by multi-factorial reasons. Serum endocan levels may be altered secondarily to decreased beta-globin chain, increased sympathetic activity due to anemia, or platelet dysfunction induced by oxidative stress in beta-thalassemia minor. Further multicenter studies involving more patients are necessary to demonstrate this.Publication Metadata only Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women(2022-01-01T00:00:00Z) ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; Güler, Eray Metin; Gülen, Bedia; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFABackground: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.Publication Open Access Report of a Case of Signet Ring Carcinoma Presenting as Gastric Mucosal Thickening: A Diagnostic Dilemma(2021-01-01T00:00:00Z) Karatoprak, Cumali; Akçakaya, Adem; Şentürk, Hakan; Çoban, Ganime; Şahin, Nurhan; Türk, Hacı Mehmet; KARATOPRAK, CUMALİ; AKÇAKAYA, ADEM; ŞENTÜRK, HAKAN; ÇOBAN, GANİME; ŞAHİN, NURHAN; TÜRK, HACI MEHMETThe number of cancer cases has been increasing worldwide. Early diagnosis and tumor resection remain as the most effective treatments for gastric cancer. However, early diagnosis is not always possible as it is frequently not possible to make treatment decisions without pathologic diagnosis in patients with clinically suspected cancer. This causes delays in diagnosing cancer. We presented a 58 years old woman with gastric signet ring cell carcinoma that could not be diagnosed despite using four different methods of stomach biopsies. We aimed to emphasize that despite the use of advanced methods, if clinical cancer in non-diagnosed cases is suspected, we should be more aggressive for early diagnosis.Publication Open Access Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?(2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNObjective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.Publication Metadata only Böbrek Yetmezliğinde Alfa-1 Adrenerjik Reseptör Blokör Kullanımı: Bir Olgu Raporu(2021-06-17T00:00:00Z) Bekler, Tubanur; Bektay, Muhammed Yunus; İzzettin, Fikret Vehbi; BEKLER, TUBANUR; BEKTAY, MUHAMMED YUNUS; KARATOPRAK, CUMALİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Sağlık Olsun(2021-02-01T00:00:00Z) Karatoprak, Cumali; KARATOPRAK, CUMALİPublication Open Access An evaluation of the relationship between vitamin D level and CTRP-9, tumor necrosis factor-alpha, thiol-disulfide hemostasis in women(2021-01-01T00:00:00Z) KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; Guler, Eray Metin; TUNÇ, MUHAMMED; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; KISKAÇ, MUHARREM; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; ÇAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; ZORLU, MEHMETObjective: Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFα, and thiol-disulfide hemostasis. We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFα, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency. Methods: In our study, 78 female volunteers older than 18 years were included. Volunteers were divided into three groups according to the reference values of vitamin D levels. Biochemical parameters, CTRP-9, TNFα, and thiol/disulfide hemostasis tests taken from all volunteers were studied. Results: In this study, there was a significant difference in CTRP-9, TNFα, total thiol (TT), native thiol (NT), DIS (disulfide), TT/DIS, and NT/DIS levels in vitamin D groups (p<0.05). There was a significant negative correlation between vitamin D and TNFα and DIS, while a significant positive correlation was found with CTRP-9, TT, NT, TT/DIS, and NT/DIS (p<0.05). Conclusions: It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFα level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress. We considered that these changes may play mediator roles for many chronic diseases and metabolic disorders that are increasing in frequency due to vitamin D deficiency.Publication Metadata only Identification of potentially inappropriate medications in elderly according to the FORTA and EU (7)-PIM lists: an observational study(2022-11-25) Özmen Ö.; Bektay M. Y.; Karatoprak C.; İzzettin F. V.; ÖZMEN, ÖZGE; BEKTAY, MUHAMMED YUNUS; KARATOPRAK, CUMALİ; İZZETTİN, FIKRET VEHBIPublication Metadata only TIP DALLARINDAKİ GELİŞMELERİN TARİHİ(2021-12-01T00:00:00Z) Karatoprak, Cumali; KARATOPRAK, CUMALİPublication Metadata only Levodopa Kullanımına Bağlı Olası İlaç Kaynaklı Pansitopeni: Bir Olgu Raporu(2021-06-17T00:00:00Z) Özkanlı, Ömer Faruk; Bektay, Muhammed Yunus; İzzettin, Fikret Vehbi; BEKTAY, MUHAMMED YUNUS; KARATOPRAK, CUMALİ; İZZETTİN, FIKRET VEHBI