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KIRAN, TUĞÇE

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Kurumdan Ayrılmıştır
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TUĞÇE
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KIRAN
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Subject: ALCL ×

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    PublicationOpen Access
    The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases
    (2013-04-01T00:00:00Z) Kiran, Tuğçe; Demirkesen, Cuyan; Eker, Candan; Kumusoglu, Hakki; Tuzuner, Nukhet; KIRAN, TUĞÇE
    Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(−) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.