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KIRAN, TUĞÇE

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TUĞÇE
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    PublicationOpen Access
    A Six Sigma Trial For Reduction of Error Rates in Pathology Laboratory
    (2016-09-01) TURNA, Seval; Tosuner, ZEYNEP; Gucin, ZÜHAL; Kiran, TUĞÇE; Buyukpinarbasili, NUR; TASKIRAN, Olcay; Arici, DİLEK SEMA; TOSUNER, ZEYNEP; GÜCİN, ZÜHAL; KIRAN, TUĞÇE; BÜYÜKPINARBAŞILI, NUR; TURNA, SEVAL; ARICI, DILEK SEMA
    Objective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.
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    PublicationOpen Access
    Intravascular/Intralymphatic Histiocytosis: A Report of 3 Cases
    (2015-10-01T00:00:00Z) Demirkesen, Cuyan; Kiran, Tuğçe; Leblebici, Cem; Yucelten, Deniz; Aksu, Ayse Esra Koku; Mat, Cem; KIRAN, TUĞÇE
    Intravascular/intralymphatic histiocytosis (IV/ILH) is a rare, reactive cutaneous condition, with uncertain pathogenesis. It may be associated with various inflammatory and neoplastic diseases. Although the clinical presentation is various, the biopsies reveal dilated vessels, mostly lymphatics, containing aggregates of histiocytes within their lumina. We described 3 cases of IV/ILH with different clinical presentations. In the first case, the patient presented with lymphedema in the genital region without any underlying disease. However, the second and third cases had reticular erythematous skin lesions. The second case had common variable immunodeficiency disease, rheumatoid arthritis, inflammatory bowel disease, and a history of a lymphoproliferative lesion. The third case had metal prostheses at both his right and left knees. In all these 3 cases, histopathologic and immunohistochemical findings were similar to each other and to those cases reported in the literature. In addition, the third case was admixed with reactive angioendotheliomatosis. In the second case, the endothelium of the ectatic vessels expressed CD31 and CD34, but not D2-40/podoplanin, pointing out that these vessels were blood vessels rather than lymphatics, differing from the other 2 cases. In conclusion, we believe, the most convincing statement about IV/ILH is that it is not a distinct clinicopathologic entity, but a histopathologic feature found as a part of a constellation of inflammatory changes or many other conditions.
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    PublicationOpen Access
    The diagnostic ability of core needle biopsy in nodular thyroid disease.
    (2017-03-01) Aysan, E; KIRAN, TUĞÇE; IDIZ, UO; AKBULUT, H; GULER, B; KUNDUZ, ENVER; ARICI, S; KADAKAL, G; Ozgor, M; Coci, K; AYŞAN, MUSTAFA ERHAN; KIRAN, TUĞÇE; GÜLER, BERIL; KUNDUZ, ENVER
    INTRODUCTION Non-diagnostic results of fine needle aspiration biopsy (FNAB) remain an important limitation of this technqiue. The aim of our study was to evaluate the results of core needle biopsy (CNB) of thyroid nodules and its effectiveness in non-diagnostic FNAB cases. METHODS CNBs were performed in 1,000 patients (154 male, 846 female; mean age: 50.2 years, range: 18–86 years) with a spring loaded 20G needle. Of these, 143 had initially had FNABs that were insufficient for evaluation. The CNB reports were reviewed. Patients with suspicious or malignant CNB results underwent total thyroidectomy. RESULTS When considering all 1,000 CNBs, the non-diagnostic rate was 1.5% (15/1,000). However, when the first 100 cases were eliminated as a learning curve, this reduced to 0.9% (8/900). Of the 143 cases with initial FNABs that were non-diagnostic, 0.7% (1/143) were also non-diagnostic on CNB. Twelve patients underwent surgery because of malignant CNB reports and all of these cases were confirmed as malignant by the postoperative pathology specimen results (100% accuracy). There were no major complications although three self-limiting minor complications were observed. CONCLUSIONS CNB is a safe and accurate method. It is more diagnostic than FNAB for nodular thyroid disease.
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    PublicationOpen Access
    Multifocal, Non-Human Papillomavirus Inflammatory Papillary Hyperplasia: A Rare Case Report
    (2022-01-01T00:00:00Z) DOĞANAY, ÖZGE; AKTAŞ, TAHA; DOLANMAZ, DOĞAN; KIRAN, Tuğçe; DOĞANAY, ÖZGE; AKTAŞ, TAHA; DOLANMAZ, DOĞAN; KIRAN, TUĞÇE
    Oral papillary lesions include a variety of reactive, developmental, and neoplastic conditions. Inflammatory papillary lesions almost involve the hard palate and are usually associated with the use of ill-fitting dentures and poor oral hygiene. Contrarily, perioral involvement of papillomatosis can also be found in neoplastic or syndromic conditions. This case report aimed to present a 44-yearold male patient with rarely encountered multifocal non-human papillomavirus (HPV) inflammatory papillary hyperplasia and evaluate the differential diagnosis that represents similar clinical and histopathological conditions. Multifocal papillary lesions on the lips, tongue, alveolar crest, and oral mucosa were surgically removed via scalpel and laser application. The histopathologic examination confirmed the diagnosis of non-HPV inflammatory papillary hyperplasia. Complete recovery was achieved and the patient was rehabilitated with a new removable prosthesis. Surgical removal of the papillary lesions seems to be a reliable treatment option. In addition to HPV-induced lesions and poor oral hygiene, other etiologic factors should be eliminated with clinicopathologic consultation and genetic investigations.
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    PublicationOpen Access
    A Rare and Unexpected Reason for Unilateral Epistaxis: Nasal Septal Schwannoma
    (2020-10-01T00:00:00Z) YENİGÜN, Alper; KULAKSIZ, YASİN; KIRAN, Tuğçe; ŞENTÜRK, Erol; Aksoy, Fadlullah; ÖZTURAN, ORHAN; YENİGÜN, ALPER; KULAKSIZ, YASİN; KIRAN, TUĞÇE; ŞENTÜRK, EROL; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    Nasal septal schwannoma is a rare tumor. It causes complaints such as nasal congestion, nosebleeds, and headaches. There are many diseases such as nasal polyps, antrochoanal polyp, chronic rhinosinusitis, concha bullosa, inverted papilloma, and retention cyst with schwannoma diagnosis. The diagnosis is made histopathologically, and the treatment is surgery. In this case report, we presented a male patient with septal schwannoma who had nasal obstruction for a year and reviewed the last 20 years of literature on nasal schwannoma.
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    PublicationOpen Access
    The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases
    (2013-04-01T00:00:00Z) Kiran, Tuğçe; Demirkesen, Cuyan; Eker, Candan; Kumusoglu, Hakki; Tuzuner, Nukhet; KIRAN, TUĞÇE
    Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(−) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.