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Now showing 1 - 4 of 4
  • Publication
    Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
    (2020-03-01T00:00:00Z) Eser, Emel; Engin, Burhan; Yuksel, PELİN; Kocazeybek, Bekir Sami; Kutlubay, Zekayi; Serdaroglu, Server; Askin, Ozge; YÜKSEL MAYDA, PELİN
    Background Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.
  • Publication
    History of Epidemics and COVID-19
    (2020-12-01T00:00:00Z) YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    In archaeological excavations, it has been reported that formations resembling bacterial fossils are found among the rock layers and they belong to millions of years ago. There are those who have created the flora and preserved us by creating our flora, and those that have brought us to the end, as well as those that help us to form the microorganisms that we share with the same planet, whose existence dates back to ancient times. Although our immune system and medical facilities are trump cards against microorganisms living in the world for much longer than human beings, these are not always enough to protect us, and microorganisms are causing outbreaks that will make history. In this review, we aimed to examine the epidemic diseases experienced by human beings from past to present and their effects.
  • Publication
    The role of typical and atypical pathogens in acute exacerbations of chronic obstructive pulmonary disease
    (2020-10-01T00:00:00Z) Yildiz, Sevilay; GÖNÜLLÜ, Nevriye; Yildiz, Birsen Pinar; Hattatoglu, Didem Gorgun; Kuskucu, Mert; MİDİLLİ, Kenan; AYGÜN, Gökhan; YÜKSEL MAYDA, PELİN; Musellim, Benan; YÜKSEL MAYDA, PELİN
    Objectives The exact role of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in the development of chronic obstructive pulmonary disease exacerbations remains to be elucidated. This study was conducted to identify nonspecific and atypical pathogens associated with acute exacerbations of COPD.
  • Publication
    SARS CoV-2 Pathogenesis and Immune Response
    (2020-12-01T00:00:00Z) Dinç, Harika Öykü; Yüksel Mayda, Pelin; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    The agent responsible for the epidemic that first appeared in Wuhan, China, in December 2019 was detected to be the new coronavirus (2019-nCoV). Later, the virus that caused respiratory tract infection was discovered to be a member of the beta-coronavirus family, it was named as severe acute respiratory syndrome-CoV2 (SARS-CoV 2), and the disease it caused was called CoV infection disease-19 (COVID-19). The epidemic started in China, spread rapidly first to East Asian countries, then Europe and America, affected the whole world, and was declared a pandemic by the World Health Organization. This review presents an overview of SARS-CoV2 and aims to examine its intracellular pathogenesis and host immune responses.