Person: ÖZCAN, PINAR
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Publication Metadata only Cardiometabolic profiles in women with adenomyosis(2022-07-01T00:00:00Z) ATEŞ, SEDA; Aydin, Serdar; ÖZCAN, PINAR; ATEŞ, SEDA; ÖZCAN, PINARThe aim of this study was to investigate the reproductive profiles, metabolic parameters and cardiometabolic risk assessed by surrogate indexes in women with adenomyosis. Ninety-six premenopausal women who were diagnosed with adenomyosis by transvaginal ultrasound and 97 age-body mass index (BMI) matched controls with normal ultrasound during routine examination were included. Women with adenomyosis were more likely to have higher gravidity and had more abortions than women without adenomyosis. Regarding the individual metabolic syndrome components, the adenomyosis group was more likely to have higher prevalence of hypertension, low HDL-C and central obesity. No significant difference was found between the groups in terms of visceral adiposity index, lipid accumulation product and fatty liver index. Only higher blood pressure (BP) remained statistically significant after adjustment for confounding factors in multivariate analysis. Women with adenomyosis had remarkably high risk of hypertension. It may be advisable to monitor their BP closely.Impact Statement What is already known on this subject? The only anthropometric characteristic assessed in women in relation to adenomyosis is body mass index (BMI). A case-control study showed that women who are obese are more likely to have adenomyosis. The gravidity, number of spontaneous abortions and previous uterine surgeries such as dilatation and curettage (D&C) and caesarean section were found significantly associated with adenomyosis. What do the results of this study add? A remarkable finding of our study was the increased incidence of higher systolic BP in women with adenomyosis. No difference was observed in adiposity indices between women with and without adenomyosis. Higher prevalence of central obesity and lower HDL-C levels were seen in women with adenomyosis. What are the implications of these findings for clinical practice and/or further research? The study identifies that adenomyosis is associated with an increased risk of hypertension, and women with adenomyosis may be monitored closely for blood pressure changes. Our report also provides novel information about the metabolic risk profiles associated with adenomyosis.Publication Open Access What Does the Data Show for Primary Ovarian Insufficiency?(2017-03-01T00:00:00Z) ÖZCAN, PINAR; Parasar, Parveen; Ficicioglu, Cem; ÖZCAN, PINARPrimary ovarian insufficiency (POI), a clinical syndrome, is defined by the exhaustion of the functional potential of ovaries prior to 40 years. The consequences of POI are potentially serious for long-term fertility, reproductive health, and general health because of early menopause. This article provides an updated review of different etiologic factors and pathogenic mechanisms that lie behind POI as well as current and novel strategies for the management of this challenging disease aimed at the primary prevention of the adverse effects of estrogen deficiency and infertility related to the early loss of ovarian function.Publication Metadata only Age-Related Distribution of Basal Anti-Mullerian Hormone Levels in a Population of Infertile Women(2016-05-01) AYDIN, SERDAR; ÖZCAN, PINAR; AYDIN, SERDARAim: We aimed to constitute age-specific reference serum values for anti-Mullerian Hormone (AMH) in women, and to analyze the distribution of basal serum AMH levels in Turkish women of reproductive age attending an infertility clinic to provide a framework for expected values according to age. Material and Method: Retrospective analysis of prospectively collected data on cycle day 2-3 serum AMH measurements of 409 women attending a single infertility unit in Turkey through a 12-month-period was performed. Results: Concentrations of serum AMH were shown to decrease with advancing age of the female partner. The mean age of the women was 34.04 +/- 5.39 years and the mean AMH level of the women was 1.77 +/- 1.82. The AMH levels were grouped according to age as follows: 20-24, 25-29, 30-34,35-39, and >40 years. The median AMH values were 2.16 ng/ml, 2.15 ng/ml, 1.71 ng/ml, 0.80 ng/ml, and 0.47 ng/ml, respectively according to the age groups. Discussion: The present data provide a framework for age-specific serum AMH levels in a Turkish population of infertile women.Publication Metadata only The cutoff values of serum AMH levels and starting recFSH doses for the individualization of IVF treatment strategies(2017-01-01T00:00:00Z) ÖZCAN, Pınar; Ficicioglu, Cem; ATEŞ, SEDA; GÜNER CAN, Meltem; Kaspar, Cigdem; Akcin, Oya; Yesiladali, Mert; ÖZCAN, PINAR; ATEŞ, SEDAObjective: The main purpose of our study is to categorize starting doses of recombinant follicle-stimulating hormone (recFSH) based on various cutoff values of anti-Mullerian hormone (AMH) and to determine the effectiveness of serum AMH levels in the prediction of poor ovarian response.Publication Metadata only Hysteroscopic findings in women with recurrent IVF failures and the effect of correction of hysteroscopic findings on subsequent pregnancy rates(2013-02-01T00:00:00Z) Cenksoy, PINAR; Ficicioglu, Cem; Yildirim, Gazi; Yesiladali, Mert; ÖZCAN, PINAROur aim is to evaluate the incidence of unrecognized uterine abnormalities in cases with recurrent IVF failure by screening office hysteroscopy (OH), and impacts of treatment of hysteroscopic findings on the success rate of IVF.Publication Metadata only Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas.(2016-03-01) Ates, SEDA; OZCAN, PINAR; Aydin, SERDAR; KARACA, N; ATEŞ, SEDA; ÖZCAN, PINAR; AYDIN, SERDARPublication Metadata only Emergency peripartum hysterectomy in a tertiary hospital in Ankara, Turkey: a 5-year review(2012-11-01T00:00:00Z) Tapisiz, Omer Lutfi; Altinbas, Sadiman Kiykac; Yirci, Bulent; Cenksoy, PINAR; Kaya, Aski Ellibes; Dede, Suat; Kandemir, Omer; ÖZCAN, PINARTo determine the incidence, indications and the risk factors of emergency peripartum hysterectomy (EPH).Publication Open Access Vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC): technique and mean 20 months outcomes(2020-12-01T00:00:00Z) ŞEVKET, OSMAN; TAKMAZ, TAHA; Sevket, A. C.; TOPRAK, ALİ; ÖZCAN, PINAR; ŞEVKET, OSMAN; TAKMAZ, TAHA; TOPRAK, ALİ; ÖZCAN, PINARThe main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse. We retrospectively reviewed the results of twenty-three women with stage III and IV prolapse treated with VALSAC between April 2017 and June 2019. With a mean follow-up of 20 months, apical pelvic organ prolapse was cured in 95.7 % of patients. There was no complication in terms of mesh exposure, persistent pain, hematoma, infection. The mean pre- and post-operative POP-Q scores were, for the Aa point, 1.61 +/- 1.82 cm and -1.96 +/- 0.87 cm (p < 0.01), for the C point, 2.87 +/- 1.6 cm and -5.26 +/- 1.86 cm (p < 0.01) for the Ap point, -1.43 +/- 0.89 cm and -2.09 +/- 0.59 cm (p < 0.01). VALSAC is a promising minimally invasive technique for pelvic floor reconstruction that appears to provide good outcomes. Content: The main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse.Publication Metadata only Perioperative low-dose ketamine improves postoperative analgesia following Cesarean delivery with general anesthesia(2016-03-01T00:00:00Z) Haliloglu, Murat; Ozdemir, Mehtap; Uzture, Neslihan; Cenksoy, PINAR; Bakan, Nurten; ÖZCAN, PINARObjective: In this study, the effect of perioperative uses of low dose ketamine on post-operative wound pain and analgesic consumption in patients undergoing elective Cesarean section was evaluated.Methods: In randomized, double blind clinical trial, 52 women with American Society of Anesthesiologists (ASA) class I-II identification undergoing elective Cesarean section in general anesthesia were enrolled. In the ketamine group (group K), a ketamine bolus of 0.5mg kg(-1) IV was administered at the time of induction of general anesthesia. After induction, a ketamine infusion of 0.25mg kg(-1) h(-1) was started and discontinued at the end of surgery. Patients allocated to the control group (group C) were given identical volumes of saline. The cumulative dose of morphine consumption after surgery was measured as the primary outcome of this study. Secondary outcomes were pain control assessed by numeric rating scale (NRS) and need for rescue analgesia and incidence of side effects.Results: The mean 24-h morphine consumption was lower in group K (p=0,001). At 15min postoperatively, NRS values were lower in group K than group C (p=0,001). There was no difference among groups regarding the need for supplemental analgesia (rescue diclofenac doses) (p>0.05).Conclusions: Perioperative uses of low dose ketamine decreased post-operative opioid requirements, which was observed long after the normal expected duration of ketamine.Publication Open Access The protective effect of platelet-rich plasma administrated on ovarian function in female rats with Cy-induced ovarian damage(2020-04-01T00:00:00Z) ÖZCAN, Pınar; TAKMAZ, TAHA; Tok, Olgu Enis; Islek, Sevde; Yigit, Esra Nur; Ficicioglu, Cem; ÖZCAN, PINAR; TAKMAZ, TAHAPurpose We evaluated the protective effect of PRP on ovarian function in female rats with cyclophosphamide (Cy)-induced ovarian damage. Methods Thirty-two adult female Sprague-Dawley rats were randomly divided into four groups. Group 1 (control-sodium chloride 0.9%; 1 mL/kg, single-dose ip injection), group 2 (Cy); 75 mg/kg, single-dose ip injection and sodium chloride 0.9% (1 mL/kg, single-dose ip injection), group 3 Cy plus PRP, Cy (75 mg/kg, single-dose and PRP (200 mu l, single-dose) ip injection), group 4 (PRP, 200 mu l, single-dose ip injection). Primordial, antral, and atretic follicle counts; serum anti-Mullerian hormone (AMH) levels; AMH-positive granulosa cells; and gene expression analysis of Ddx4 were assessed. Results Serum AMH levels were significantly lower in group 2 compared to groups 1, 3, and 4 (p < 0.01, p < 0.01, and p = 0.04, respectively). A significant difference was found in the primordial, primary, secondary, antral, and atretic follicle counts between all groups (p < 0.01). There was a statistically significant difference in AMH-positive staining primary, secondary, and antral follicles count between the groups (p < 0.01). There was a statistically significant difference in primary, secondary, and antral AMH positive staining follicle intensity score between the groups (p < 0.01). Ddx4 expression in group 4 was highest compared to other groups. Conclusion Our study may provide evidence that PRP could protect ovarian function against ovarian damage induced by Cy. It could lead to improved primordial, primary, secondary, and antral follicle numbers.