Person: DÜNDAR, TOLGA TURAN
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Publication VENTRİKÜLO-PERİTONEAL ŞANTIN GEÇ KOMPLİKASYONU: DÖRT OLGUDA PERİTONEAL KATETERİN ANAL PROLAPSUSU(2011-04-26) SEYİTHANOĞLU, MEHMET HAKAN; GUNDAG, MELİHA; DOGAN, KAZIM; KİTİŞ, SERKAN; öztürk, şeref; DÜNDAR, TOLGA TURAN; Çevik, Serdar; SEYİTHANOĞLU, MEHMET HAKAN; GUNDAG, MELİHA; KİTİŞ, SERKAN; DÜNDAR, TOLGA TURANPublication Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.(2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHABackground: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposurePublication The Role of Staged Cryosurgery and Three-Dimensional Computed Tomography Integrated Navigation System in the Surgical Management of Severe Involvement of Craniofacial Polyostotic Fibrous Dysplasia(2020-01-01T00:00:00Z) Dündar, Tolga Turan; YILDIZ, KEMALETTİN; DÜNDAR, TOLGA TURAN; MEHDIZADE, TURAN; GÜNEREN, ETHEMFibrous dysplasia (FD) is a developmental bone disorder caused by the hamartamatous proliferation of bone-forming cells. A 29-year-old male patient with diagnosis of FD was admitted to our clinic with the symptoms of severe craniomaxillofacial involvement of FD beginning from last year. Neurological examination revealed diplopia, horizontal nystagmus, conductive hearing loss, and partial vision loss. In his medical history, it was reported that he had undergone intramedullary nailing operation in his left femur due to a pathological fracture approximately 8 years ago in the orthopedics clinic of our institution. The patient underwent 3 consecutive surgeries by our plastic and neurosurgical team. The patient was followed-up in the neuro-intensive care unit between the surgical sessions and 1 week after the last operation. Afterwards, he was transferred to the neurosurgical department. No postoperative complication was detected. The preoperative signs were recovered. During his 6th month follow-up control-visit, all his preoperative symptoms were improved. In addition, the patient was satisfied with his postoperative cosmetic improvement. In conclusion, virtual surgical planning and intraoperative surgical navigation systems can make the challenging cases possible to operate with increasingPublication Anevrizmatik subaraknoid kanama sonrası prognostik faktör olarak platelet volüm indeksinin değerlendirilmesi(2019-09-01) Dündar, Tolga Turan; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; YURTSEVER, İSMAİLPublication The Effectiveness of Hyperbaric Oxygen Therapy in an Established Intracerebral Tumor Model(2015-07-01) DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; KORPINAR, ŞEFİKA; ATAR, RAZİYE; EVRAN, ŞEVKET; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKANObjective: Gliomas are the most common brain tumor in adults. Tumor-related endothelial cells are of neoplastic nature and have malignant properties such as proliferation and invasion. Therefore, antiangiogenic approaches have several advantages compared with conventional chemotherapeutic approaches. The target of antiangiogenic treatment is to ensure a decrease in systemic side effects because there are endothelial cells and other supportive cells belonging to the vessel walls. The purpose of this study was to increase the oxygenation of the environment with hyperbaric oxygen therapy (HBOT) and to prevent the angiogenic effect of hypoxia- related factors. We also tried to prevent angiogenesis by using sorafenib (SOR), which is a chemotherapeutic agent that blocks the receptors of these factors. Also, this study compared the effect of these both and to put into for their effect. In this regard, parameters such as the tumor size, vascularization rate, midkine (MK), apoptosis- and angiogenesis-related transcription tumor necrosis factor (TNF) alfa, and IL6 were compared in the relevant groups. Methods: For this purpose, a convenient trial model was formed and the following 4 groups were determined: The study population was divided into four main groups: G1-control group, G2-group given HBOT, G3-group given SOR, G4-group given HBOT and SOR. Ten rats were included in each group. After 2 weeks, the rats were sacrificed. After being sacrificed based on the date and surgery determined, the tumor volume and vascularization ratio were checked with light microscope. Serum samples are evaluated by using ELISA for TNF-alpha, Interleukin-6 (IL- 6) and midkine (MK) levels. Results: The underlying mechanism of HBOT by evaluating MK levels was shown for the first time in this study. We have found that HBOT potentializes the sorafenib efficacy. HBOT increased MK levels and HBOT decreased anti-apoptotic TNF-α and IL-6 levels. MK levels show inverse correlation with TNF-α levels and IL-6 levels. TNF-α and IL-6 levels are directly proportional. Conclusion: There is a need for further studies to evaluate the correct time of application of HBOT.Publication Talamusun Fonksiyonel Nöroanatomisi (Functional Neuroanatomy of the Thalamus)(2019-01-22T00:00:00Z) DÜNDAR, TOLGA TURAN; DÜNDAR, TOLGA TURANPublication Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP inResidue Evaluation of Treated Intracranial Aneurysms(2017-11-10T00:00:00Z) DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; Toprak, Huseyin; Kitiş, Serkan; Ozek, Erdinc; UYSAL, ÖMER; ALKAN, ALPAY; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; UYSAL, ÖMER; ALKAN, ALPAYPublication Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.(2021-01-01T00:00:00Z) Aslan, T; Guler, E M; Dundar, T; Cakir, A; Gulgec, A S; Huseyinbas, O; Celikten, M; Coban, G; Hakyemez, I N; Kocyigit, ABDÜRRAHİM; Durdu, B; DÜNDAR, TOLGA TURAN; KOÇYİĞİT, ABDÜRRAHİMObjective: Colistin is a potent antibiotic which is mainly preferred in the treatment of multidrug-resistant (MDR) gram-negative bacilli. However, due to the increased risk of acute kidney injury following its use, the clinical application is limited. This nephrotoxicity is known to be induced by oxidative stress and related inflammation. In this study on rats, potent antioxidants Dexpanthenol (DEX) and Ascorbic acid (Vit C) have been administered in combination with Colistin to find out whether they would weaken Colistin's nephrotoxic effects. Materials and methods: Inflammation biomarkers were studied with enzyme-linked immunosorbent assay (ELISA) kits, and oxidative stress biomarkers were studied with different photometric methods in blood and tissue samples taken after treatment with DEX and Vit C in rats with colistin nephrotoxicity. In addition, inflammation and necrosis in the kidney tissues were examined pathologically. Results: It has been observed in the serum and tissue samples that DEX and Vit C decrease oxidative stress and inflammation biomarkers, therefore acting as nephroprotective agents. Conclusions: These compounds have been found to ameliorate the nephrotoxic effects of Colistin, which were demonstrated in the rats treated with Colistin, as well as the combinations.Publication Fonksiyonun Cerrahi Anatomisi(2018-11-01) GÖKOĞLU, ABDULKERİM; DÜNDAR, TOLGA TURAN; DÜNDAR, TOLGA TURANPublication NÖROFİBROMATOZİS TİP-1’Lİ BİR HASTADA EKZOFİTİK DEV HÜCRELİ GLİOBLASTOMA: OLGU SUNUMU(2017-04-02) GUNDAG, MELİHA; KİTİŞ, SERKAN; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN; GUNDAG, MELİHA; KİTİŞ, SERKAN; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN