Person: YENİGÜN, VILDAN BETÜL
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VILDAN BETÜL
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YENİGÜN
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Publication Unknown Attachment of oxadiazole ring to tetrazole containing proteasome inhibitor increases celldeath in ER+ breast cancer cells(2024-03-12) YENİGÜN V. B.; Özkan H.; KANIMDAN E.; ÖZKAN H.; KOÇYİĞİT A.; YENİGÜN, VILDAN BETÜL; KANIMDAN, EBRU; KOÇYİĞİT, ABDÜRRAHİMPublication Unknown Evaluating Cytotoxic Effects and Cytotoxicity Origins of Bulk-Fill Materials by LC-MS/MS.-(2022-09-17T00:00:00Z) Kazak, Mağrur; Dönmez, Nazmiye; Bahadori, Fatemeh; Yenigün, Vildan Betül; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Unknown Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.(2021-08-19T00:00:00Z) Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betül; Demiray, Mutlu; Eroğlu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Unknown Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Unknown Investigating the Cytotoxicity of Dual-Cure Bulk-Fill Resin Materials on L929 Cells(2022-08-01T00:00:00Z) Köymen, Safiye Selin; Dönmez, Nazmiye; Yenigün, Vildan Betül; Bahadori, Fatemeh; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access (CCUG)<sub>n</sub> RNA toxicity in a <i>Drosophila</i> model of myotonic dystrophy type 2 (DM2) activates apoptosis.(2017-08-01T00:00:00Z) Yenigun, VİLDAN BETÜL; SIRITO, M; AMCHESLAVKY, A; CZERNUSZEWICZ, T; COLONQUES-BELLMUNT, J; GARCÍA-ALCOVER, I; WOJCIECHOWSKA, M; BOLDUC, C; CHEN, Z; López, Castel; KRAHE, R; BERGMANN, A; YENİGÜN, VILDAN BETÜLPublication Metadata only Comparison of Chondrocytes Produced from Adipose Tissue-Derived Stem Cells and Cartilage Tissue(2013-05-01) Yenigun, Vildan Betul; MERIC, Aysenur; Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Spontaneous cartilage regeneration is poor after a cartilage defect occurs by trauma, surgical, and other reasons. Importance of producing chondrocytes from stem cells and using tissues to repair a defect is getting popular. The aim of this study was to compare the effects of injectable cartilage produced by chondrocytes differentiated from adipose tissue-derived mesenchymal stem cells and chondrocyte cells isolated directly from cartilage tissue.Publication Metadata only Copper (II) increases anti-proliferative activity of thymoquinone in colon cancer cells by increasing genotoxic, apoptotic and reactive oxygen species generating effects.(2019-10-15T00:00:00Z) Yenigün, Vildan Betül; Gül, Ayşe Zehra; YENİGÜN, VILDAN BETÜL; GÜL, AYŞE ZEHRAPublication Metadata only Design of Curcumin Loaded Levan-PLGA Nanoparticles for Active Targeted Cancer Therapy(2018-04-27) Eskandar, Zahra; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Eroglu, Mehmet S; BAHADORİ, FATEMEH; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; BAHADORİ, FATEMEH