Person: BALLI, UMUT
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Publication Metadata only Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial(2015-09-01T00:00:00Z) Dogan, Seyma Bozkurt; Dede, Figen Ongoz; Balli, UMUT; Atalay, Elif N.; Durmuslar, Mustafa C.; BALLI, UMUTAimThe aim of this study was to determine the clinical effect of concentrated growth factor (CGF) in combination with coronally advanced flap (CAF) compared to CAF alone for the treatment of multiple adjacent gingival recessions (GRs).Publication Metadata only The effect of initial periodontal treatment on plasma, gingival crevicular fluid and salivary levels of 8-hydroxy-deoxyguanosine in obesity(2016-02-01T00:00:00Z) Dede, Figen Ongoz; Dogan, Seyma Bozkurt; Balli, UMUT; Avci, Bahattin; Durmuslar, Mustafa Cenk; BALLI, UMUTObjective: Recent studies have shown adverse effects on the periodontium from the increased production of reactive oxygen species (ROS) in obesity. The purpose of this study was to investigate the effects of obesity on 8-hydroxy-deoxyguanosine (8-OHdG) levels in the bodily fluids of patients with and without periodontal disease and to evaluate changes after initial periodontal treatment.Publication Metadata only The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-alpha in the gingival crevicular fluid of obese patients following periodontal therapy(2016-12-01T00:00:00Z) Balli, UMUT; Dogan, Seyma Bozkurt; Dede, Figen Ongoz; Sertoglu, Erdim; Keles, Gonca Cayir; BALLI, UMUTThe aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-a. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-alpha (P < 0.008), which declined following treatment (P< 0.025), and lower omentin levels (P <0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome.Publication Metadata only Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus(2016-08-01T00:00:00Z) Dogan, Seyma Bozkurt; Balli, UMUT; Dede, Figen Ongoz; Sertoglu, Erdim; Tazegul, Kaan; BALLI, UMUTBackground: The objectives of the present study are to: 1) determine whether gingival crevicular fluid (GCF) chemerin is a novel predictive marker for patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (t2DM); 2) analyze the relationship between chemerin and interleukin (IL)-6 in periodontally healthy individuals and in patients with CP and with and without t2DM; and 3) evaluate the effect of non-surgical periodontal therapy on GCF chemerin levels.Publication Metadata only Impact of Three Different Education Methods on Oral Hygiene and Theoretical Knowledge of Schoolchildren(2018-01-01T00:00:00Z) Demiriz, Levent; Dede, Figen Ongoz; Balli, UMUT; BALLI, UMUTObjective: To evaluate the impact of three different education methods on the oral hygiene levels of school children using clinical and theoretical findings. Material and Methods: 144 children (72 males and 72 females), whose ages ranged between 8-13, were divided into 12 equal experimental groups according to their ages and gender. They were all considered to have poor hygiene. Only one out of the three different education methods (brochure, model or video) was applied to each group. The percentage change in PI, GI, BOP and theoretical test points from the baseline to the 6th months were evaluated. The data was statistically analysed by using Kolmogorov-Smirnov and One-way ANOVA tests. Results: Reduction in PI, GI and BOP scores was significantly greater (p0.05). There was no significant difference in test points in 8-10 and 11-13-year-old female groups (p>0.05), whereas a significant increase in test points was observed in the video and model applied groups compared to the brochure groups in 8-10 and 11-13-year-old male groups (p<0.05). Conclusion: It may be more helpful and effective for children to get the oral hygiene education using the visual methods, especially for those under the age of ten.Publication Metadata only Evaluation of the effects of platelet-rich fibrin on bone regeneration in diabetic rabbits(2016-02-01T00:00:00Z) Durmuslar, M. Cenk; Balli, UMUT; Dede, Figen Ongoz; Dogan, Seyma Bozkurt; Misir, A. Ferhat; BARIŞ, EMRE; Yilmaz, Zehra; ÇELİK, HAKAN HAMDİ; Vatansever, Alper; BALLI, UMUTObjectives: This study aimed to investigate the effect of platelet-rich fibrin on bone regeneration in critical size defects in the calvaria of diabetic rabbits.Publication Metadata only Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor-kappa B Ligand in Periodontitis(2015-12-01T00:00:00Z) Aydogdu, Ahmet; Balli, UMUT; Dede, Figen Ongoz; Turer, Cigdem Coskun; Guven, Berrak; BALLI, UMUT; AYDOĞDU, AHMETBackground: To investigate changes in the levels and relative ratios of sclerostin, osteoprotegerin (OPG), and receptor activator of nuclear factor-kappa B ligand (RANKL) in the gingival crevicular fluid (GCF) of patients with periodontitis after non-surgical periodontal treatment.Publication Metadata only Histological Evaluation of the Effect of Concentrated Growth Factor on Bone Healing(2016-09-01T00:00:00Z) Durmuslar, Mustafa Cenk; Balli, UMUT; Dede, Figen Ongoz; Misir, Ahmet Ferhat; BARIŞ, EMRE; KÜRKÇÜ, MEHMET; Kahraman, Sevil Altindag; BALLI, UMUTObjectives:The aim of this study was to evaluate the effects of concentrated growth factors (CGF) on the healing of peri-implant bone defects in an animal model.Study Design:Twenty 4-month-old New Zealand White rabbits, each with an average weight of 3.5kg, were used in this blinded, prospective, experimental study. Two implants were placed and 2 peri-impant defects were prepared in each rabbit tibia. Bone defects were created monocortically in the tibia of each rabbit using a trephine burr with a diameter of 8mm. The implants were installed in each hole. The rabbits were divided into 4 groups: in group E, the defect was left empty; in group CGF, the defects were filled only with CGF; in group AB, the defects were filled with autogenous bone; and in group AB+CGF, the defects were filled with autogenous bone and CGF. The animals were euthanized at week 8 postimplantation. All implants from the 20 animals were fixed in 10% formalin and evaluated histomorphometrically.Results:The mean defect area was highest in group E and lowest in group CGF+AB (P<0.05). The area of the defect differed significantly between groups AB and CGF+AB (P<0.05), but not between groups CGF and E. Implant-to-bone contact was lowest in group E. In the defect areas of groups CGF, AB and CGF+AB, a small amount of new bone formed around the implant.Conclusions:In this animal model of a peri-implant bone defect, restoration was achieved using a combination of autogenous bone and CGF. Further studies are needed to determine the behavior of CGF when used in the repair of bone defects in humans.Publication Metadata only Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus(2016-09-01T00:00:00Z) Dogan, Seyma Bozkurt; Dede, Figen Ongoz; Balli, UMUT; Sertoglu, Erdim; BALLI, UMUTThe aims of the present study were to determine the levels of vaspin and omentin-1 in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM), and to evaluate GCF vaspin and omentin-1 levels after non-surgical periodontal therapy. The study included 60 subjects: 15 systemically and periodontally healthy individuals, 15 periodontally healthy patients with T2DM, 15 systemically healthy patients with CP, and 15 patients with both CP and T2DM. GCF and clinical periodontal parameters were examined at the baseline and 6 weeks after periodontal therapy. Levels of vaspin, omentin-1 and tumor necrosis factor-alpha (TNF-alpha) were measured by ELISA, and their relative ratios were calculated. GCF vaspin and TNF-alpha levels were significantly higher in the CP groups than in the periodontally healthy groups (P < 0.008) and decreased after therapy in the former (P < 0.025). GCF omentin-1 levels were significantly lower in the CP groups than in the periodontally healthy groups (P < 0.008) and increased after therapy in the former (P < 0.05). Statistically significant positive correlations were found between the total amount of vaspin and TNF-alpha, glycated hemoglobin (HbA1c), clinical attachment level and gingival index, whereas the level of omentin-1 was negatively correlated with these parameters in all groups (P < 0.05). We found that non-surgical periodontal therapy influenced the GCF levels of both vaspin and omentin-1 in the CP groups. Our results suggest that the levels of vaspin and omentin-1 in GCF could have potential application as inflammatory markers of diabetes, periodontal disease and treatment outcome.