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ARALAŞMAK, AYŞE

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2013 - 20143
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Author: AKKOYUNLU, MUHAMMED EMİN × Author: Aralasmak, AYŞE × Type: Article ×

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Now showing 1 - 3 of 3
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    PublicationOpen Access
    The Effect of Obesity on Brain Diffusion Alteration in Patients with Obstructive Sleep Apnea
    (2014-01-01) KILICARSLAN, Rukiye; Alkan, ALPAY; Sharifov, RASUL; Akkoyunlu, MUHAMMED EMİN; Aralasmak, AYŞE; KOCER, Abdulkadir; KART, Levent; ALKAN, ALPAY; SHARIFOV, RASUL; AKKOYUNLU, MUHAMMED EMİN; ARALAŞMAK, AYŞE
    Purpose: We investigated diffusion alterations in specific regions of the brain in morbid obese, obese, and nonobese OSA patients and searched whether there is a correlation between BMI and ADC values. Materials and methods: DWIs of 65 patients with OSA were evaluated. The patients were classified according to BMI as morbid obese (n = 16), obese (n = 27), and nonobese (control, n = 22) groups. ADC measurements were performed from 24 different regions of the brain in each patient. The relationship of BMI with ADC values was searched. Results: The ADC values in hypothalamus, insular cortex, parietal cortex, caudate nucleus, frontal white matter, and posterior limb of internal capsule were all increased in obese patients (n = 43) compared to control group. The ADC values of midbrain, hypothalamus, orbitofrontal cortex, and parietal cortex were significantly increased in morbid obese compared to obese patients. In obese patients, the degree of BMI was positively correlated with ADC values of orbitofrontal cortex, parietal cortex, and hypothalamus. Conclusion: We observed increasing brain vasogenic edema with increasing BMI, suggesting that the main reason of brain diffusion alteration in patients with OSA could be obesity related.
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    PublicationOpen Access
    Brain Diffusion Changes in Obstructive Sleep Apnoea Syndrome
    (2013-01-01) Akkoyunlu, MUHAMMED EMİN; Kart, Levent; KILICARSLAN, Rukiye; Bayram, MEHMET; Aralasmak, AYŞE; Sharifov, RASUL; Alkan, ALPAY; AKKOYUNLU, MUHAMMED EMİN; BAYRAM, MEHMET; ARALAŞMAK, AYŞE; SHARIFOV, RASUL; ALKAN, ALPAY
    Background: Obstructive sleep apnoea syndrome (OSAS) is a disorder characterized by repeated apnoeic episodes during sleep. Neurocognitive changes secondary to OSAS are likely to occur due to hypoxia in certain brain locations. Advances in magnetic resonance imaging technology, such as diffusion-weighted imaging (DWI), enable non-invasive and accurate identification of OSAS-induced changes. Objective: We aimed to use DWI to investigate changes in the brain secondary to hypoxia in OSAS. Methods: Eighty-eight patients underwent polysomnography and were classified as non-OSAS, mild-moderate OSAS and severe OSAS sufferers. DWI was used to evaluate 14 areas of the brain, and apparent diffusion coefficients (ADCs) were calculated. We investigated whether there were differences in the ADC values in specific areas of the brain between the non-OSAS and OSAS patients. Results: We measured the ADC values of the 68 newly diagnosed OSAS patients (21 mild, 15 moderate and 32 severe) and of 20 healthy controls. There were significant increases in the ADC values in the hippocampus, amygdala and putamen in OSAS patients. Compared to thenon-OSAS subjects, the ADC values of the putamen in severe OSAS patients, those of the hippocampus in moderate or severe OSAS patients and those of the amygdala in moderate OSAS patients were significantly increased. A negative correlation between the lowest oxygen saturation during sleep and the ADC values of the hippocampus and amygdala was found. Conclusions: Increased ADC levels in the hippocampus, amygdala and putamen in OSAS patients indicate hypoxia and likely cause vasogenic oedema in specific regions of the brain.
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    MR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome
    (2013-11-01) Alkan, ALPAY; SHARIFOV, Resul; Akkoyunlu, MUHAMMED EMİN; KILICARSLAN, Rukiye; Toprak, HÜSEYİN; Aralasmak, AYŞE; KART, Levent; ALKAN, ALPAY; AKKOYUNLU, MUHAMMED EMİN; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞE
    Purpose: We investigated whether there are differences in metabolite ratios of different brain regions between mild and severe obstructive sleep apnea (OSA) patients. Materials and methods: A total of 17 mild OSA and 14 severe OSA patients were enrolled. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr and NAA/Cho ratios were calculated by using multivoxel magnetic resonance spectroscopy (MRS) (TR: 1500, TE: 135 ms) from hippocampus, putamen, insular cortex, thalamus and temporal white matter. The relationship between the two groups was evaluated with Mann-Whitney U test Results: NAA/Cr ratios obtained from hippocampus was found to be significantly increased in severe OSA patients compared to mild OSA patients (P=.004). Cho/Cr ratios obtained from hippocampus and putamen in severe OSA patients were significantly increased when compared to mild OSA patients (P=.003 and P=.004, respectively). In addition, NAA/Cho ratios of putamen were significantly decreased in severe OSA patients when compared to mild OSA (P=.032). Conclusion: MRS identified hypoxia-related metabolite and microstructural changes in hippocampus and putamen. The metabolite changes of increase in NAA/Cr and Cho/Cr ratios and decrease in NAA/Cho ratio were more pronounced with increasing severity of OSA syndrome. (C) 2013 Elsevier Inc. All rights reserved.