Person: UYGUR ŞAHİN, TÜRKAN
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Publication A Rare Presentation of Systemic Lupus Erythematosus during Childhood: Chorea(2017-04-01T00:00:00Z) DOĞAN DEMİR, AYŞEGÜL; Kucukkoc, Mehmet; Goknar, Nilufer; UYGUR ŞAHİN, TÜRKAN; ERENBERK, UFUK; DOĞAN DEMİR, AYŞEGÜL; UYGUR ŞAHİN, TÜRKAN; ERENBERK, UFUKSystemic lupus erythematosus (SLE) is a systemic, chronic, inflammatory, autoimmune disease characterized by multi-organ and - system involvement such as the kidneys and hematologic and central nervous systems. The clinical presentation of the disease is extremely variable. Systemic findings, nephritis, neuropsychiatric disease, and cytopenia are more common in children than in adults at presentation. Chorea typically manifests with jerky, involuntary, and purposeless movements, involving the face, four limbs, and neck. In addition, patients suffer from dysarthria, gait disturbance, and neuropsychiatric symptoms. Chorea can be the first finding of SLE during childhood. Herein we reported a 13-year female patient who presented with movement and speech disorders and who was diagnosed chorea-related SLE.Publication 2-10 Aylık Bebeği Olan Annelerde Bebek-Taşıyıcısının Annenin Ağrısıyla İlişkisi(2022-09-24) Pehlivan S.; Tanrıverdi M.; Uygur Şahin T.; TANRIVERDİ, MÜBERRA; UYGUR ŞAHİN, TÜRKANPublication Clinical significance of human metapneumovirus in refractory status epilepticus and encephalitis case report(2015-12-06T00:00:00Z) VEHAPOĞLU TÜRKMEN, AYSEL; TÜREL, ÖZDEN; UYGUR ŞAHİN, TÜRKAN; KUTLU, NURETTİN ONUR; İŞCAN, AKIN; VEHAPOĞLU TÜRKMEN, AYSEL; TÜREL, ÖZDEN; UYGUR ŞAHİN, TÜRKAN; KUTLU, NURETTİN ONUR; İŞCAN, AKINPublication The effectiveness of cerebellar lesions on neurocognitive functions in children with neurofibromatosis Type 1: Diffusion tensor imaging features(2021-04-01T00:00:00Z) Toprak, Mekiya Filiz; Çeşme, Dilek Hacer; Kaya, Ahmet; Gültekin, Mehmet Ali; Aydın, Sinem; Uygur Şahin, Türkan; Alkan, Alpay; ÇEŞME, DİLEK HACER; KAYA, AHMET; GÜLTEKİN, MEHMET ALİ; UYGUR ŞAHİN, TÜRKAN; ALKAN, ALPAYIn children with Neurofibromatosis type 1 (NF1), hamartomatous lesions called FASI (focal areas of signal intensity) on brain MRI are common. The relationship between neurocognitive functions and the presence of cerebellar FASI in NF1 children is a controversial issue. Our aim in this study is to investigate whether there is a difference in fractional anisotropy (FA) and mean diffusivity (MD) values in children with NF1 with and without cerebellum FASI, and to analyze its effect on neurocognitive functions. Twenty-seven patients children were assessed using Diffusion Tensor Imaging (DTI) and MRI. According to MRI features, we classified children with NF1 as group 1 with FASI (n=14) in the cerebellum, group 2 without FASI (n=13). The WISC-R scale (a revised form of the Wechsler intelligence scale for children) was used to analyze cognitive functions. MD and FA values were measured from cerebellar FASI and white matter. The relationship between neurocognitive function test scores and FA and MD values was investigated. There was a significant difference between group 1 and group 2 in terms of MD and FA values of the cerebellum. Verbal and performance test scores were lower in group 1 and group 2. The MD values obtained from the cerebellum were positively correlated with the full-scale intelligence quotient (IQ), Verbal IQ, and Performance IQ. There was a significant difference between group 1 and group 2 in terms of information, vocabulary, digit span, picture arrangement. DTI changes in the cerebellum are associated with demyelination and loss of axonal integrity in the white matter pathways responsible for some neurocognitive functions. We think that the presence of cerebellar FASI in children with NF1 does not contribute to the severity of neurocognitive impairment.