Person: KÜTÜK, NÜKHET
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Publication Displacement of a Dental Implant and Cover Screws into Submandibular Space: A Case Report.(2017-05-23T00:00:00Z) AKKOYUN, EMİNE FULYA; DEMİRBAŞ, AHMET EMİN; TAŞDEMİR, ZEKERİYA; KÜTÜK, NÜKHET; ALKAN, ALPER; AKKOYUN, EMİNE FULYA; KÜTÜK, NÜKHET; ALKAN, ALPERPublication OXFORD DİŞ HEKİMLİĞİ SÖZLÜĞÜ(2018-01-01T00:00:00Z) AĞRALI, ÖMER BİRKAN; AK, GÜLSÜM; ALKAN, ALPER; ALTAN, GÜLAY; ARİFOĞLU, YASİN; AYTUĞAR, EMRE; BALCIOĞLU, HÜSEYİN AVNİ; BALCIOĞLU, NİLÜFER; BÜYÜKERTAN, METE; SUNGURTEKİN EKÇİ, ELİF; ERDEM, TAMER LÜTFİ; ERDEMİR, UĞUR; EROL, FUNDA; ERTAŞ, ÜMİT; GÜRSOY, HARE; İLGÜY, DİLHAN; ÖZKAN KARACA, EBRU; ÖZDEMİR KARATAŞ, MELTEM; KARAPINAR KAZANDAĞ, MERİÇ; KESKİN, BAŞAK; KÖSE, TAHA EMRE; KÜTÜK, NÜKHET; MARŞAN, GÜLNAZ; ÖZDEMİR ÖZENEN, DİDEM; ORHAN, KAAN; ÖZCAN, İLKNUR; ERMİŞ, RABİA BANU; SÜBAY, RÜSTEM KEMAL; ŞENER, YAĞMUR; ORDULU SÜBAY, MELİKE; TATLI, UFUK; TEKİN, UĞUR; ÖZÇAKIR TOMRUK, CEYDA; TUNA, SÜLEYMAN HAKAN; TUNÇDEMİR, ALİ RIZA; TÜRKÜN, LEZİZE ŞEBNEM; UYANIKGİL, YİĞİT; YAZICI, AYŞE RÜYA; YILDIZ, ESRA; YILMAZ, NERGİZ; KÜTÜK, NÜKHETPublication Effects of combination TGF-B1 transfection and platelet rich plasma (PRP) on three-dimension chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells(2019-10-13) Salkin, Hasan; GÖNEN, ZEYNEP BURÇİN; ÖZCAN, SERVET; Lekesizcan, Ayca; BAHAR, DİLEK; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPERAim: The aim of this study was to evaluate the effects of standard culture medium and chondrogenic differentiation medium with PRP on chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells (rabbit DPSCs) that are transfected with transforming growth factor-beta 1 (TGF-B1) gene, based on the hypothesis of TGF- B1 and PRP can be effective on the chondrogenesis of stem cells. Materials and Methods: Rabbit DPSCs were characterized by using flow cytometry, immunofluorescent staining, quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and differentiation tests. For the characterization, CD29, CD44 and CD45 mesenchymal cell markers were used. Rabbit DPSCs were transfected with TGF-B1 gene using electroporation technique in group 1; with PRP 10% in group 2; with chondrogenic medium in group 3; with both chondrogenic medium and PRP in group 4. DPSCs were cultured in medium with 10% inactive PRP in group 5, chondrogenic medium in group 6, chondrogenic medium with PRP 10% in group 7. SOX9, MMP13 and Aggrecan gene expression levels were evaluated in 3, 6, 12. and 24. days by qRT-PCR. Results: The expression levels of SOX9, MMP13 and Aggrecan were higher in group 2, 3 and group 7 in 3th day however in 24th day group 7 and group 2 were found higher. The expression levels changed by time-dependent. The extracellular matrix of the cells in experimental groups were positively stained with safranin O and toluidine blue. Conclusion: The combination in culture medium of TGF-B1 gene transfection and 10% PRP accelerates the chondrogenic differentiation of DPSCs.Publication Intravenous ketamine, propofol and propofol-ketamine combination used for pediatric dental sedation: A randomized clinical study(2016-05-01) Kutuk, Nukhet; Canpolat, Dilek Gunay; Yildirim, Mustafa Denizhan; AKSU, RECEP; Alkan, ALPER; Cantekin, Kenan; KÜTÜK, NÜKHET; ALKAN, ALPERBackground and Objective: Dental treatments cannot be always performed under local anesthesia in pediatric non-cooperative patients. For this purpose, different anesthetic techniques have been applied to increase patient comport to dental treatments.Publication Evaluation of aggrecan and adipokine levels in temporomandibular joint synovial fluid(2022-05-01) Bayındır Ş.; YILMAZ ASAN C.; DEMİRBAŞ A. E.; BARLAK KETİ D.; KÜTÜK N.; KÜTÜK, NÜKHET© 2021The aim of this study was to investigate the effect various mediators in synovial fluid (SF) on the pathogenesis of temporomandibular disorders (TMD) and to evaluate the relationship between clinical and radiological features of temporomandibular joint (TMJ) diseases. Patients who had received SF sample during arthrocentesis because of TMD were included in this study. Clinical and radiological records were evaluated retrospectively. Enzyme-Linked ImmunoSorbent Assay (ELISA) method was used for analysis of aggrecan, adiponectin, resistin, apelin, Vascular Endothelial Growth Factor (VEGF) and Prostaglandin E2 (PGE2) in SFs. 59 joints of 41 patients were included in the study. Anterior disc displacement with reduction (ADDwR) was detected in 22 joints, anterior disc displacement without reduction (ADDwoR) was detected in 29 joints and osteoarthritis (OA) in 8. In OA group, PGE2 level was significantly higher than the other groups (p = 0.029). Aggrecan and PGE2 levels were statistically higher in joints with localized pain (p = 0.030, p = 0.029). The aggrecan level was statistically significant higher in patients who had degenerative changes in radiological examinations (p = 0.044). Resistin was correlated with PGE2 and aggrecan (p = 0.011), and apelin showed positive correlation with VEGF (p˂0.001). The detection of aggrecan and adipokines in SF may be a precursor of degenerative joint disease and it should be taken into account that the presence of localized pain in the joint area may be an early sign of degenerative changes.Publication Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted Rapid Orthodontics(2019-11-01T00:00:00Z) GÖNEN, ZEYNEP BURÇİN; ALKAN, Alper; Ekizer, Abdullah; KÜTÜK, Nükhet; Tasdemir, Zekeriya; ALKAN, ALPER; KÜTÜK, NÜKHETBackground: Corticotomy-assisted rapid orthodontics is a widely used method for speeding up conventional orthodontics. This study (i) evaluates the effects of corticotomy alone, corticotomy combined with bone graft, and corticotomy with platelet-rich fibrin (PRF) on vestibular alveolar bone thickness in patients with class I malocclusion; (ii) compares the treatment time with a conventional orthodontic therapy group, and (iii) investigates the periodontal health of patients who have undergone corticotomy-assisted rapid orthodontics.Publication Segmental Distraksiyon ile Alveol Yarık Onarımı: 2 Olgu Sunumu(2023-02-23) VATANSEVER S.; Pergel T.; AKKOYUN E. F.; KÜTÜK N.; DOLANMAZ D.; KILIÇ B.; YARADANAKUL K.; AKKOYUN, EMİNE FULYA; KÜTÜK, NÜKHET; DOLANMAZ, DOĞAN; KILIÇ, BANUPublication Comparison of the effects of ozone therapy and photobiomodulation on sciatic nerve injury in rats(2021-11-01T00:00:00Z) GÜNAY CANPOLAT, DİLEK; YÜCESOY, TÜRKER; Colpak, Halis Ali; KAYA, ÖZLEM TUĞÇE; Kolbasi, Bircan; Saraymen, Recep; Karaturk, Habip; KÜTÜK, NÜKHET; CANPOLAT, MEHMET; YÜCESOY, TÜRKER; KÜTÜK, NÜKHETAim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days of surgery and treatments, tissue specimens and blood samples were taken for histological and biochemical processing. Histological evaluations were performed at light and electron microscopy levels. Myelin basic protein (MBP) and S100 from the rat serum were analysed also. Results: The OT and PBM groups had a significant increase in regeneration of the sciatic nerve in light microscopic evaluation. In the PBM and OT groups, Schwann cells (SC) around the axons and also axons with a thin myelin sheath were seen, regarded as signs of the myelination process in transmission electron microscopy (TEM) examinations. Discussion: OT and PBM both resulted in a good healing pattern for sciatic nerve injury in the rat model. Therefore, OT and PBM are considered to be simple and reliable alternative treatment methods for PNI.Publication Graft Necrosis Occurred After Iliac Crest Reconstruction After Mandibular Segmental Resection of AmeloblastomaBulut, Emel; Bekcioglu, Burak; Bas, Burcu; KÜTÜK, NÜKHETAmeloblastoma is an uncommon benign odontogenic neoplasm of the maxillofacial region constituting less than 1% of tumors of the oral cavity. Ameloblastomas have been categorized broadly into 3 biologic variants: cystic (unicystic), solid, and peripheral. Unicystic ameloblastoma is a rare and less aggressive variant of ameloblastoma. The aim of this report is to describe a case of cystic ameloblastoma treated with segmental resection and iliac graft reconstruction. The possible reasons of graft failure seen in our patient at the early stage of the healing were also discussed.Publication The Effect Of Local Release Alendronate Applied With Bone Grafts In Maxillary Sinus Lifting In Rabbits On New Bone Formation: A Micro-CT Analysis Study(2019-04-28T00:00:00Z) YILMAZ, GÖKHAN; DEMİRBAŞ, AHMET EMİN; ÜNAL, SEDAT; AKTAŞ, YEŞİM; BİLGE, SUHEYB; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPER